New sedative may make lung exams safer and smoother

NCT ID NCT07184801

Symptom relief Sponsor: Post Graduate Institute of Medical Education and Research, Chandigarh Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests whether dexmedetomidine, a sedative, works better than midazolam for keeping patients comfortable during medical thoracoscopy—a procedure where doctors look inside the chest cavity. About 56 adults with unexplained fluid around the lungs will be randomly assigned to receive one of the two drugs. The goal is to see if dexmedetomidine reduces the need for extra pain medicine, shortens recovery time, and lowers the risk of complications.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance: Dexmedetomidine (a sedative drug)
What this could lead to: If it works, this could point toward a better sedation option for lung procedures, making them safer and more comfortable for patients.
What could go wrong: This is a small, early-phase trial with only 56 participants, so results may not apply to everyone. Both drugs have known side effects like low blood pressure or slow heart rate.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 3

Large-scale testing in a bigger group. Usually the last step before a treatment can be approved.

Participants

About 56 people

The number the study aims to enrol. It can still change while the study runs.

Started

Oct 2025

Expected to finish

Dec 2026

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

12 to 90 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. Age≥18 and ≤80 years 2. Medical thoracoscopy performed for the work-up of undiagnosed pleural effusion Exclusion Criteria: 1. Patients with ICD in situ for more than 5 days 2. SP02\<92% 3. Haemodynamic instability (systolic blood pressure ≤90 mmHg or \>180mmHg, or diastolic BP \>110mmHg) before the procedure 4. MI/unstable angina in the last 3 months 5. Hb\<8g/dL, platelet\<50000 cells/dL 6. Lack of pleural space due to adhesion 7. Uncorrected coagulopathy (PT\>3 secs above control; APTT\>10 secs above control 8. Failure to provide informed consent 9. Patients with known allergy or previously recorded severe adverse events to the sedatives used in the study 10. Patients who required any anaesthetic/analgesic agent in past 7 days 11. Patients on psychotropic drugs that may alter sensorium

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Medical thoracoscopy

How to take part

Only the study team decides who joins. These are the ways to reach them.

The places running it

1 site. The list below names each one and where it is.
The official record

ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

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A doctor treating you

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New sedative may make lung exams safer and smoother

What the study statuses mean