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Can a common sedative boost microcirculation during keyhole surgery?

NCT ID NCT04946396

Knowledge-focused Sponsor: National Institute of Cardiology, Laranjeiras, Brazil Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested whether giving dexmedetomidine, a sedative, during laparoscopic gallbladder removal improves blood flow in the smallest blood vessels. Researchers used a special camera to look at the lining of the mouth in 64 adults. The goal was to see if the drug helps keep tiny vessels open and working well during anesthesia.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
dexmedetomidine
What this could lead to
If it works, this could help doctors choose anesthetics that protect small blood vessels during surgery, potentially improving recovery.
What could go wrong
This is a small, completed study with only 64 participants. It measures a temporary effect during surgery, not long-term outcomes, so results may not change practice directly.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

64 people

The number who actually took part.

Started

Apr 2022

Finished

Aug 2025

Lead sponsor

A government agency

The lead sponsor is a government body.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 60 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Adult patients of both sexes (age ≥ 18 and ≤ 60 years) * Physical state ASA I or II according to the criteria of the American Association of Anesthesiology * Planned surgery of cholecystectomy by videolaparoscopy Exclusion Criteria: * Patient's refusal to participate in the study * Inflammation or infection in the sublingual mucosa * Emergency surgery * Grade III obesity (BMI ≥39.9 kg/m2) * Pregnancy or lactation * Autoimmune diseases, malignant neoplasms

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Laparoscopic surgery

Contacts and locations

Locations

  • Eduardo Tibiriçá

    Rio de Janeiro, 22240006, Brazil

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