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Simple drug may stop Post-Surgery confusion in seniors

NCT ID NCT05436964

Symptom relief Sponsor: Chinese PLA General Hospital Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looked at whether giving a medicine called dexmedetomidine during major abdominal surgery can lower the chance of confusion (delirium) in patients aged 65 and older. About 268 elderly patients took part, and researchers checked for confusion twice a day while they were in the hospital. The goal was to see if the drug helps keep older adults clearer-headed after surgery.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

268 people

The number who actually took part.

Started

Jul 2022

Finished

May 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

65 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Patients over 65 years old * Patients undergoing elective major abdominal surgery * Written informed consent was obtained Exclusion Criteria: * Patients with severe preoperative cognitive impairment (MMSE ≤ 20) who are unable to undergo a follow-up evaluation. * Patients with history of psychiatric or neurological disorders. * Patients with body mass index ≤ 18 or ≥ 30 * Patients with severe bradycardia (heart rate less than 40 beats per minute) * Patients with pathological sinus node syndrome or grade 2 or greater AV block * Patients with severe hepatic or renal insufficiency. * Patients with severe hypertension (systolic blood pressure ≥ 180 mmHg or diastolic blood pressure ≥ 110 mmHg)

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Conditions

The condition(s) this trial relates to.

delirium

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Delirium in old age

Contacts and locations

Locations

  • Beijing Tiantan Hospital,Capital Medical University

    Beijing, China

  • Central theater General Hospital

    Wuhan, China

  • Chinese PLA General Hospital

    Beijing, China

More trials for these conditions

Other studies related to the condition(s) this trial covers.