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Can a common sedative keep agitated lung patients off ventilators?

NCT ID NCT06567587

Symptom relief Sponsor: Tanta University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested whether dexmedetomidine, a sedative, can safely calm agitation in 70 COPD patients with psychosis who were using non-invasive breathing masks. The goal was to see if it could prevent the need for a breathing tube. Researchers measured how many patients needed invasive ventilation and tracked agitation levels.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
dexmedetomidine
What this could lead to
If it works, this could offer a way to calm agitated COPD patients on breathing support, possibly reducing the need for a breathing tube.
What could go wrong
This is a small, completed study with only 70 participants. Results may not apply to all patients, and sedation carries risks like low blood pressure or slow heart rate.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

70 people

The number who actually took part.

Started

Jun 2024

Finished

Mar 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Patients who will meet the previous criteria will be enrolled in the study. Patients will be classified into two equal groups; 35 patients will be enrolled in each group; all patients will receive loading dose of dexmedetomidine 1 μg/kg in 10 min then maintenance dose 0.2-0.7 μg/kg/hr till obtain adequate sedation level guided by Richmond agitation score.

Ages

18 to 60 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Patients aged 18 - 60 years, ASA III (agitated and exacerbated COPD patients). Exclusion Criteria: * Patients with GCS \< 8 (need invasive ventilation). * Failure of non-invasive ventilation. * Patients with fascial trauma or surgery. * Patients with esophageal varices. * Patients with recent GIT surgeries.

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Conditions

The condition(s) this trial relates to.

chronic obstructive pulmonary disease psychotic disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Response of agitated patients to dexmedetomidine

Contacts and locations

Locations

  • Tanta

    Tanta, Tanta, 0020, Egypt

More trials for these conditions

Other studies related to the condition(s) this trial covers.