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Heart surgery showdown: could a simple gas beat standard anesthesia?

NCT ID NCT07116733

Disease control Sponsor: Xijing Hospital Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study compares two anesthetics—desflurane gas and propofol—during coronary artery bypass surgery. Researchers want to see if desflurane helps prevent major heart problems like heart attack or heart failure within 30 days after surgery. About 3,560 adults having planned bypass surgery will take part.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
desflurane (inhaled anesthetic)
What this could lead to
If desflurane works better than propofol, it could become the preferred anesthetic for heart bypass surgery to lower the risk of serious heart complications after the operation.
What could go wrong
This is a large phase 3 trial, but it's still possible that desflurane offers no advantage over propofol. The study focuses on short-term outcomes (30 days), so long-term benefits are unknown.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 3

Large-scale testing in a bigger group. Usually the last step before a treatment can be approved.

Participants

About 3,560 people

The number the study aims to enrol. It can still change while the study runs.

Started

Oct 2025

Expected to finish

Dec 2029

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. Patients scheduled for elective coronary artery bypass grafting (CABG) 2. Age ≥ 18 years old; 3. Sign the informed consent form. Exclusion Criteria: 1. Emergency or urgent operation 2. Concomitant valve or aortic surgery 3. History of myocardial infarction in recent 30 days 4. Current use of myocardial preconditioning-affecting medications, such as sulfonylurea (glibenclamide), allopurinol, theophylline, nicorandil(last dose \< 8 hrs), etc 5. Participated in other randomized controlled clinical trials in recent 3 months 6. General anesthesia in recent 30 days 7. History of kidney and liver transplantation, or severe liver and kidney dysfunction (EGFR ≤ 20 mlgmin/1.73 m2, conventional dialysis or patients who have started dialysis; Child Pugh grade C/cirrhosis) 8. History of open heart surgery; 9. Hemodynamic instability or severe heart failure (SBP\<90 mmHg or preoperative need of high-dose vasoactive drug support, placement of aortic balloon pump (IABP), ECMO or ventricular assist device, left ventricular ejection fraction\<30%) 10. Adverse drug reactions to trial medications 11. History of malignant hyperthermia 12. Pregnancy or lactation

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Conditions

The condition(s) this trial relates to.

coronary artery disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Cardiac surgery Coronary artery bypass grafting

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    14 sites. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Cangzhou People's Hospital

    NOT_YET_RECRUITING

    Cangzhou, Hebei, China

  • Changhai Hospital

    RECRUITING

    Shanghai, China

  • Daping Hospital, Army Medical University

    NOT_YET_RECRUITING

    Chongqing, China

  • Fuzhou University Affiliated Provincial Hospital

    NOT_YET_RECRUITING

    Fuzhou, Fujian, China

  • Hebei General Hospital

    NOT_YET_RECRUITING

    Shijiazhuang, Hebei, China

  • Jiangsu Province Hospital

    NOT_YET_RECRUITING

    Nanjin, Jiangsu, China

  • Ningbo No.2 Hospital

    NOT_YET_RECRUITING

    Ningbo, Zhejiang, China

  • Sichuan Provincial People's Hospital

    NOT_YET_RECRUITING

    Chengdu, Sichuan, China

  • The First Affiliated Hospital of Zhengzhou University

    NOT_YET_RECRUITING

    Zhengzhou, Henan, China

  • The First Hospital of Hebei Medical University

    NOT_YET_RECRUITING

    Shijiazhuang, Hebei, China

  • Tianjin Chest Hospital

    RECRUITING

    Tianjin, Tianjin Municipality, China

  • Wuhan Asia Heart Hospital

    NOT_YET_RECRUITING

    Wuhan, Hubei, China

  • Xijing Hospital

    RECRUITING

    Xi'an, Shaanxi, 710032, China

  • Zhongshan Hospital, Fudan University

    NOT_YET_RECRUITING

    Shanghai, China

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