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Can a fatty acid cream heal damaged skin? new trial tests it

NCT ID NCT07366255

Disease control Sponsor: Shenzhen People's Hospital Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This completed trial tested a cream made from a fatty acid called tripalmitoleoylglycerol in 46 adults with chronic dermatitis. Participants applied the cream or a placebo daily for 30 days. Researchers measured skin barrier function and symptom scores to see if the cream improved skin health.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
tripalmitoleoylglycerol (a type of fatty acid cream)
What this could lead to
If it works, this could point toward a new topical treatment for chronic dermatitis that improves skin barrier function.
What could go wrong
This is a small, early-phase trial with only 46 participants, so results may not apply to everyone. The cream may not work better than placebo.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

46 people

The number who actually took part.

Started

Jan 2026

Finished

Mar 2026

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 59 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria： 1. Participants were classified into two groups based on their self-reported levels of physical activity (quantified in metabolic equivalent minutes per week \[MET-min/week\]): the non-exercising group (MET = 0): individuals who reported no moderate- or vigorous-intensity physical activity beyond activities of daily living. In this context, a value of 0 MET-min/week indicates that no structured or intentional exercise exceeding the threshold of basal metabolic rate was performed. Exercise group (MET \> 0): This group includes any individual who engages in at least some level of physical activity, with a calculated MET-min/week value greater than 0. 2. Presence of clinical manifestations of skin barrier impairment, such as skin dryness, erythema, scaling, or pruritus; 3. Voluntary participation with full understanding of the study and provision of written informed consent; 4. Age between 18 and 59 years, with generally good health status; 5. No use of any medications or probiotic treatments within the past 6 months; Exclusion Criteria： 1. History of allergy or known hypersensitivity to probiotics, placebo, or investigational products; 2. Presence severe systemic diseases; 3. Pregnant or breastfeeding women; 4. Use of medications that may affect skin barrier function, such as corticosteroids or immunosuppressive agents; 5. Any other condition deemed inappropriate for study participation by the investigators, including but not limited to participants considered unreliable or unable to understand or comply with study assessments

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Conditions

The condition(s) this trial relates to.

dermatitis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Pasi /scorad index Skin barrier to water loss

Contacts and locations

Locations

  • Department of Dermatology, Shenzhen People's Hospital

    Shenzhen, Guangdong, 518000, China

More trials for these conditions

Other studies related to the condition(s) this trial covers.