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Could licorice root help treat depression? new study investigates

NCT ID NCT05570110

Symptom relief Sponsor: Philipps University Marburg Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests whether enoxolone, a compound from licorice, can improve depression symptoms in 80 adults with unipolar depression. Researchers will measure biomarkers like hormone levels and blood pressure to see if they predict who responds better to enoxolone versus a placebo. The goal is to find a more personalized treatment approach for depression.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 1/2

Runs two stages together: safety and dose first, then whether the treatment works.

Participants

About 80 people

The number the study aims to enrol. It can still change while the study runs.

Started

Sep 2022

Expected to finish

Jun 2026

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Unipolar Depression * in women: Contraceptive means Exclusion Criteria: * Schizophrenic and delusional disorders * Neurological diseases in which central nervous system involvement is known, such as epilepsies, storage diseases; severe mental retardation * Internistic diseases of moderate or higher severity, which may make participation in the study risky from a clinical point of view. In particular, multiple systolic blood pressure (measured after at least 5 min supine position) of \> 145 mm Hg as well as hypokalemia (\< 3.5 mmol/l) and clinically relevant ECG changes * Poorly controlled diabetes mellitus (HbA1c \> 10) * Pregnancy or active desire for pregnancy for the duration of the study * Non-consent or inability to consent to the study * Treatment with the following substances: spironolactone or eplerenone; systemic glucocorticoids * Treatment with ketamine or electroconvulsive therapy in the last 3 months before randomization * Acute suicidality * Intolerance to licorice preparations or licorice contents.

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Conditions

The condition(s) this trial relates to.

depressive disorder endogenous depression

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Unipolar depression

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Clinic for Psychiatry and Psychotherapy

    RECRUITING

    Marburg, Hesse, 35039, Germany

More trials for these conditions

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