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10-Year showdown: stents or pills for blocked arteries?

NCT ID NCT06908499

Disease control Sponsor: Seung-Jung Park Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study follows 840 people with a completely blocked coronary artery (chronic total occlusion) for at least 10 years. Half received a drug-eluting stent, and half got optimal medical therapy alone. Researchers will compare rates of death, heart attack, stroke, and repeat procedures to see which approach works better in the long run.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
drug-eluting stent
What this could lead to
If successful, this could show that stents provide better long-term outcomes than medication alone for patients with completely blocked coronary arteries.
What could go wrong
This is a long-term follow-up study, not a new treatment. Results may not change current practice if stents show no clear advantage over medication.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 840 people

The number the study aims to enrol. It can still change while the study runs.

Started

Apr 2026

Expected to finish

Dec 2026

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Patients with chronic total occlusion who were enrolled in the original DECISION-CTO trial (NCT01078051)

Ages

19 years and older

Sex

Anyone

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. Clinical 1) Patients with angina or silent ischemia and documented ischemia 2) Patients who are eligible for intracoronary stenting 3) Age \>18 years 2. Angiographic 1) De novo lesion Chronic Total Occlusion (CTO) 2) Reference vessel size ≥ 2.5 mm by visual estimation 3) At least one CTO lesions located in proximal or mid epicardial coronary artery. (If the patient has two CTO lesions, one CTO lesion should be located in proximal or mid epicardial coronary artery) 3. CTO definition: TIMI (Thrombolysis in Myocardial Infarction) flow 0 or 1 with estimated duration over 3 months * The duration of the occlusion was determined by the interval from the last episode of acute coronary syndrome, or * In patients without a history of acute coronary syndrome, from the first episode of effort angina consistent with the location of the occlusion 1. Angiographically defined total occlusion over 3 months 2. If no definite symptom with total occlusion, two experienced operators decide CTO in consideration of angiographical morphology (degree of calcification, bridging collaterals, non-tapered stump, angiographic filling from collaterals) Exclusion Criteria: 1. History of bleeding diathesis or coagulopathy 2. Pregnant state 3. Three vessel CTOs 4. Known hypersensitivity or contra-indication to contrast agent and heparin 5. ST-elevation acute myocardial infarction requiring primary stenting 6. Culprit total occlusion presented with acute coronary syndrome suggesting acute or recent occlusion 7. Characteristics of lesion 1) Left main disease 2) In-stent restenosis 3) Graft vessels 4) Distal epicardial coronary artery CTO lesions 5) Two vessel proximal segment CTOs 8. Hematological disease (Neutropenia \<3000/mm3, Thrombocytopenia \<100,000/mm3) 9. Hepatic dysfunction, liver enzyme (ALT and AST) elevation ≥ 3 times normal 10. Renal dysfunction, creatinine ≥ 2.0mg/dL 11. Contraindication to aspirin, clopidogrel or other commercial antiplatelet agent 12. Left ventricular ejection fraction \<30% 13. Patients who are actively participating in another drug or device investigational study, which have not completed the primary endpoint follow-up period. 14. Non-cardiac co-morbid conditions are present with limited life expectancy or that may result in protocol non-compliance (per site investigator's medical judgment).

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Conditions

The condition(s) this trial relates to.

coronary artery disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Coronary artery disease

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    19 sites in 5 countries. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Asan Medical Center

    RECRUITING

    Seoul, South Korea

  • Bundang CHA Hospital

    RECRUITING

    Seongnam, South Korea

  • Chonnam National University Hospital

    RECRUITING

    Gwangju, South Korea

  • Chungnam National University Hospital

    RECRUITING

    Daejeon, South Korea

  • Dong-A Medical Center

    RECRUITING

    Busan, South Korea

  • Gangneung Asan Hospital

    RECRUITING

    Gangneung, South Korea

  • Hallym University Hangang Sacred Heart Hospital

    RECRUITING

    Seoul, South Korea

  • Kangbuk Samsung Hospital

    RECRUITING

    Seoul, South Korea

  • Kangwon National University Hospital

    RECRUITING

    Chuncheon, South Korea

  • Keimyung University Dongsan Medical Center

    RECRUITING

    Daegu, South Korea

  • King Chulalongkorn Memorial Hospital

    RECRUITING

    Bangkok, 10330, Thailand

  • Korea University Guro Hospital

    RECRUITING

    Seoul, South Korea

  • Medistra Hospital

    RECRUITING

    Jakarta, DKI Jakarta, 12950, Indonesia

  • Ruby Hall Clinic

    RECRUITING

    Pune, Maharashtra, 411001, India

  • SAM hospital

    RECRUITING

    Anyang, South Korea

  • Shin Kong Wu Ho-Su Memorial Hospital

    RECRUITING

    Taipei, Taipei City, 111013, Taiwan

  • Soon Chun Hyang University Hospital Bucheon

    RECRUITING

    Bucheon-si, South Korea

  • The Catholic University of Korea, Daejeon St. Mary's Hosptial

    RECRUITING

    Daejeon, South Korea

  • Ulsan University Hospital

    RECRUITING

    Ulsan, South Korea

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