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Scientists hunt for clues to chronic pain after surgery in tiny blood molecules

NCT ID NCT06418295

Knowledge-focused Sponsor: London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's Source: ClinicalTrials.gov ↗

What the study statuses mean

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 26, 2026 · Last updated Jun 26, 2026

Summary

This pilot study looks at why some people develop chronic pain after chest surgery. Researchers will collect blood samples from 60 patients before and after surgery to measure certain molecules (cytokines) and check if changes in gene activity (epigenetics) are linked to long-term pain. The goal is to gather initial data for larger studies, not to test a new treatment.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If successful, this study could point toward ways to predict or prevent chronic pain after surgery by targeting specific cytokines or epigenetic changes.
What could go wrong
This is a very early pilot study with only 60 participants, so results may not apply to everyone. It is designed to gather information, not to test a treatment.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 60 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Jan 2026

An estimate. Start dates often move.

Expected to finish

Dec 2028

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Adult patients scheduled to undergo thoracotomy for malignancy at Victoria Hospital, London Health Science Centre.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. 18 years of age or older 2. Undergoing unilateral thoracotomy for the first time on that side 3. Willing to provide informed consent for study participation. 4. Patient with malignancy that needs thoracotomy for surgical resection. Exclusion Criteria: 1. Chronic pain prior to surgery 2. Pre-existing fibromyalgia 3. Long-term opioid use 4. Diabetes mellitus 5. Inflammatory bowel disease 6. Pre-existing neurological disease 7. Pre-existing nerve injury 8. Evidence of dementia, delirium or cognitive disorder that may interfere with study participation 9. Malignancy other than lung cancer 10. Autoimmune disorder (e.g. rheumatoid arthritis and psoriatic arthritis) 11. Pregnancy 12. Inability to communicate in the English language (required for completion of questionnaires and provision of pain scores). 13. Patents on antiepileptic medications

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Conditions

The condition(s) this trial relates to.

Chronic Pain lung cancer Pain, Postoperative

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Chronic post operative pain

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  2. A doctor treating you

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