Can an antibody boost help transplant patients beat CMV faster?

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria - all study arms: * Written informed consent obtained from the subject before any trial-related procedures are performed * \>= 18 years and \<= 75 years of age at time of consent * Able to perform routine blood testing (standard care for transplant recipients) * Understands and can read English Inclusion criteria - high viral load arm: * Recipient of an organ transplant (lung, heart, liver, kidney, pancreas, intestine alone or in combination) and on immunosuppression * CMV DNAemia ≥ 50,000 IU/ml in the first 2 weeks of CMV antiviral treatment with CMV antiviral dose appropriately adjusted for renal function Inclusion criteria - CMV primary infection after liver transplantation arm: \- Liver transplant recipients who are CMV IgG negative and received a CMV IgG positive donor (CMV D+/R-) with a primary CMV infection, defined as detected CMV DNAemia, including detected but below the limit of quantitation Inclusion criteria - CMV primary infection after lung transplantation arm: \- Lung transplant recipients who are CMV D+/R- with a primary CMV infection after discontinuation of CMV antiviral prophylaxis, defined as detected CMV DNAemia, including detected but below the limit of quantitation Exclusion Criteria: * History of hypersensitivity to or a prior severe reaction associated with the administration of CytoGam or other human immunoglobulin preparation * Receipt of effective CMV antiviral treatment, appropriately adjusted for renal function, for greater than or equal to 14 days prior to enrollment * Selective IgA deficiency, as they may produce antibodies against immunoglobulin A (IgA), leading to potential anaphylactic reactions upon administration of blood products containing IgA, including CMV immunoglobulin (e.g. CytoGam or similar) * Prior history of hematopoietic cell transplant * Pregnancy * Participation in another interventional clinical trial at time of consent or within 30 days prior to study consent * Any condition which, in the judgement of the investigator, would make administration of CytoGam unsafe