New study pits two needle procedures against each other for wrist pain relief
NCT ID NCT07269613
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study compares two minimally invasive treatments for carpal tunnel syndrome: pulsed radiofrequency (using heat pulses) and hyaluronidase hydrodissection (injecting a fluid to free the nerve). About 56 adults with mild to moderate carpal tunnel will be randomly assigned to one of the two procedures. The goal is to see which provides faster and better pain relief and improves hand function.
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Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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About 56 people
The number the study aims to enrol. It can still change while the study runs.
- Expected to start
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Dec 2025
An estimate. Start dates often move.
- Expected to finish
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Jul 2026
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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20 to 80 years
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
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Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: 1. Adults aged 20-80 years 2. Clinical diagnosis of CTS with symptoms for at least 3 months 3. Electrophysiological evidence of mild to moderate CTS 4. No previous intervention for CTS in the affected hand Exclusion Criteria: 1. Previous wrist surgery or trauma 2. Medical history of polyneuropathy, thoracic outlet syndrome, or brachial plexopathy 3. Coagulopathy or local infection at injection site 4. Pregnancy or breastfeeding
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The places running it
1 site. The list below names each one and where it is.
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The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
Contacts and locations
Locations
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Faculty of Medicine Sohag University
Sohag, Sohag Governorate, Egypt
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- Three shots, one wrist: which injection best eases carpal tunnel?
- Scalpel vs sound waves: two carpal tunnel surgeries go head to head
- Can carpal tunnel surgery restore more than hand function?
- Does nerve healing keep pace with hand recovery after carpal tunnel surgery?
- Retraining the brain to ease carpal tunnel pain: a new approach put to the test
- Can a Two-Session acupuncture treatment match ten sessions for carpal tunnel?