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New biologic injection takes on steroids for rotator cuff pain — but study pulled

NCT ID NCT06712290

Symptom relief Sponsor: Allegheny Singer Research Institute (also known as Allegheny Health Network Research Institute) Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled This study
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This pilot study aimed to compare a single injection of connective tissue matrix (CTM) against a standard corticosteroid shot for treating rotator cuff tendinopathy. Participants would have been randomly assigned to one of the two injections and followed for six months with questionnaires and physical tests. However, the study was withdrawn before enrolling any patients, so no data were collected.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Connective tissue matrix (CTM) injection
What this could lead to
If it works, this could offer a biologic alternative to steroid injections for shoulder pain, potentially with fewer side effects.
What could go wrong
This trial was withdrawn before enrolling any participants, so no results exist. The approach is very early and unproven.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Started

Nov 2024

Finished

Dec 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 80 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Patients aged 18-80 years old with rotator cuff tendinopathy * A corticosteroid or CTM-type injection was determined by the clinician to be the proper medical treatment course and patient is willing to undergo the injection Exclusion Criteria: * Patients with adhesive capsulitis * Patients with acromio-clavicular joint impingement, retracted tears, significant labral lesions or significant glenohumeral arthrosis * Patients with joint instability * History of shoulder surgery or corticosteroid injection in the past 3 months * Patients with a history of chronic steroid treatment for any medical reason * Patients with medical conditions that may affect healing, such as * End-stage renal disease * Uncontrolled diabetes * Peripheral vascular disease * Severe and/or systemic immunocompromising conditions such as Lupus or HIV infection * Patients who are pregnant or breast feeding

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Conditions

The condition(s) this trial relates to.

disease of the tendon rotator cuff syndrome

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Rotator cuff tendinopathy

Contacts and locations

Locations

  • Allegheny Health Network Federal North Medical Office Building

    Pittsburgh, Pennsylvania, 15212, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.