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Blood test may spare thousands from unnecessary colonoscopies after diverticulitis

NCT ID NCT06023004

Diagnosis Sponsor: University of Aarhus Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing This study
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looks at whether a blood test that detects tumor DNA can help decide which people with diverticulitis need a colonoscopy to check for colorectal cancer. Currently, almost everyone with diverticulitis is advised to get a colonoscopy, but many are unnecessary. The researchers will compare the blood test results with colonoscopy findings in 220 participants to see if the blood test is accurate enough to guide decisions.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
blood test for circulating tumor DNA (ctDNA)
What this could lead to
If successful, this blood test could help doctors decide who really needs a colonoscopy after diverticulitis, reducing unnecessary procedures and costs.
What could go wrong
This is a small, early-stage study with only 220 participants. The blood test may not be accurate enough to replace colonoscopy, and results may not apply to all patients.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 250 people

The number the study aims to enrol. It can still change while the study runs.

Started

May 2022

Expected to finish

May 2030

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Patients with newly CT-verified diverticulitis will be identified by the attending physician at the recruiting surgical departments. Patients fulfilling the inclusion criteria are approached and invited to participate.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * CT-verified diverticulitis eligible for a follow-up colonoscopy Exclusion Criteria: * Unable to provide oral and written informed consent * Recent colonic imaging and no need for renewed visualization of the colonic mucosa deemed by the attending doctor

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Conditions

The condition(s) this trial relates to.

colorectal cancer colorectal neoplasm diverticulitis diverticulitis of colon

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Acute diverticulitis Colonic diverticulitis Colorectal cancer

Contacts and locations

Locations

  • Herlev Hospital

    Herlev, Capital Region of Denmark, 2730, Denmark

  • Odense University Hospital

    Odense, The Region of Southern Denmark, 5000, Denmark

  • Regional Hospital Horsens

    Horsens, Central Jutland, 8700, Denmark

  • Regional Hospital Randers

    Randers, Central Jutland, 8930, Denmark

  • Regional Hospital Viborg

    Viborg, Central Jutland, 8800, Denmark

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