Blood test may help some breast cancer patients avoid extra treatment
NCT ID NCT07214532
First seen Nov 01, 2025 · Last updated May 01, 2026 · Updated 31 times
Summary
This study looks at whether a blood test (Signatera) can help decide when to start a targeted therapy (CDK4/6 inhibitor) in people with intermediate-risk HR+/HER2- breast cancer. Participants will either start the extra therapy if the blood test shows signs of remaining cancer, or continue standard hormone therapy with regular monitoring. The goal is to see if this approach can maintain effectiveness while reducing unnecessary treatment. About 725 participants will be followed for up to 9 years.
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Locations
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Adventist Health/AIS Cancer Center
NOT_YET_RECRUITINGBakersfield, California, 93301, United States
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Allegheny (AHN)
NOT_YET_RECRUITINGPittsburgh, Pennsylvania, 15212, United States
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Atrium Levine Cancer Institute
NOT_YET_RECRUITINGCharlotte, North Carolina, 28204, United States
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Baptist MD Anderson
NOT_YET_RECRUITINGJacksonville, Florida, 32207, United States
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Cancer & Hematology Centers
NOT_YET_RECRUITINGGrand Rapids, Michigan, 49504, United States
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Cooper Health
NOT_YET_RECRUITINGCamden, New Jersey, 08103, United States
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Fred Hutch Cancer Center
NOT_YET_RECRUITINGSeattle, Washington, 98109, United States
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Hartford Healthcare Institute
NOT_YET_RECRUITINGHartford, Connecticut, 06102, United States
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Honor Health Research Institute
NOT_YET_RECRUITINGScottsdale, Arizona, 85258, United States
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Houston Methodist Hospital
NOT_YET_RECRUITINGHouston, Texas, 77030, United States
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Jupiter Medical Cancer
NOT_YET_RECRUITINGJupiter, Florida, 33458, United States
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Kaiser Permanente NorCal
NOT_YET_RECRUITINGVallejo, California, 94589, United States
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Karmanos Cancer Center - Wayne State University
NOT_YET_RECRUITINGDetroit, Michigan, 48201, United States
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Loma Linda University
NOT_YET_RECRUITINGLoma Linda, California, 92354, United States
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Marin Cancer Care
NOT_YET_RECRUITINGGreenbrae, California, 94904, United States
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Mayo Clinic
NOT_YET_RECRUITINGRochester, Minnesota, 55905, United States
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Mayo Clinic Arizona
NOT_YET_RECRUITINGPhoenix, Arizona, 85054, United States
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Mayo Clinic Florida
NOT_YET_RECRUITINGJacksonville, Florida, 32224, United States
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Mercy Health - Pratt Cancer Center
NOT_YET_RECRUITINGSt Louis, Missouri, 63141, United States
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Mercy Health - Sindelar Cancer Center
NOT_YET_RECRUITINGSt Louis, Missouri, 63128, United States
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Miami Cancer Institute
NOT_YET_RECRUITINGMiami, Florida, 33176, United States
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MultiCare Cancer Institute
NOT_YET_RECRUITINGTacoma, Washington, 98405, United States
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Munson Medical Center Cowell Family Cancer Center
NOT_YET_RECRUITINGTraverse City, Michigan, 49684, United States
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New England Cancer Specialists
NOT_YET_RECRUITINGWestbrook, Maine, 04092, United States
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New York Cancer and Blood Specialists
NOT_YET_RECRUITINGBabylon, New York, 11702, United States
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Northwest Cancer Center
RECRUITINGDyer, Indiana, 46311, United States
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Northwest Medical Specialties, PLLC
NOT_YET_RECRUITINGPuyallup, Washington, 98373, United States
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Northwestern University
NOT_YET_RECRUITINGChicago, Illinois, 60611, United States
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Ocala Oncology
NOT_YET_RECRUITINGOcala, Florida, 34474, United States
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Rutgers
NOT_YET_RECRUITINGNew Brunswick, New Jersey, 08901, United States
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Sanford Health
NOT_YET_RECRUITINGSioux Falls, South Dakota, 57104, United States
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Stockton Hematology Oncology Medical Group
RECRUITINGStockton, California, 95204, United States
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UCLA David Geffen School of Medicine
NOT_YET_RECRUITINGSanta Monica, California, 90404, United States
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University of Alabama at Birmingham
NOT_YET_RECRUITINGBirmingham, Alabama, 35294, United States
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University of Arizona Cancer Center
NOT_YET_RECRUITINGTucson, Arizona, 85719, United States
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Vanderbilt
NOT_YET_RECRUITINGNashville, Tennessee, 37232, United States
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West Cancer Center
NOT_YET_RECRUITINGGermantown, Tennessee, 38138, United States
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West Virginia University
NOT_YET_RECRUITINGMorgantown, West Virginia, 26506, United States
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Yale Cancer Center
NOT_YET_RECRUITINGNew Haven, Connecticut, 06520, United States
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Conditions
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