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Chill out: cryotherapy tested for MS fatigue

NCT ID NCT05219201

Symptom relief Sponsor: Fondation Ildys Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested whether partial-body cryotherapy (standing in a very cold chamber for 2-3 minutes) could help reduce fatigue in people with multiple sclerosis during a rehabilitation stay. 43 participants received either real cryotherapy at -120°C or a sham version at -30°C over 15 sessions. The main goal was to see if fatigue scores improved.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
partial-body cryotherapy (device)
What this could lead to
If it works, this could offer a drug-free way to manage fatigue in multiple sclerosis during rehabilitation stays.
What could go wrong
This is a small, completed trial with only 43 participants, so results may not apply to everyone. The effect on fatigue is measured by a questionnaire, not a direct biological test.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

43 people

The number who actually took part.

Started

Sep 2022

Finished

Jul 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 65 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * men and woen over 18 years old and under 65 years old * with multiple sclerosis * 0-6 points in the expanded disability states scale (EDSS) * with MS in remission (at least 6 months since the last relapse) * able to understand and respect the protocol and its requirement * who signed the consent prior to any other procedure protocol Exclusion Criteria: * major patients under guardianship/curators/legal protection * pregnant patients * patients with contraindication for cryotherapy * patients unable to complete the entire program * patients with substantial change in pharmacological treatment the month before the start of the study

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Conditions

The condition(s) this trial relates to.

Depression Fatigue insomnia multiple sclerosis Muscle Spasticity

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Multiple sclerosis

Contacts and locations

Locations

  • Centre de Perharidy

    Roscoff, France

More trials for these conditions

Other studies related to the condition(s) this trial covers.