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Freezing pain: new study tests if nerve blocks can predict cryoneurolysis success

NCT ID NCT07289984

Knowledge-focused Sponsor: Universitair Ziekenhuis Brussel Source: ClinicalTrials.gov ↗

What the study statuses mean

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study looks at whether a diagnostic nerve block can predict how well cryoneurolysis—a procedure that uses extreme cold to temporarily freeze nerves—will work for people with long-term muscle and bone pain. Researchers will enroll 50 adults with chronic pain and measure pain levels and walking ability before and after treatment. The goal is to see if the nerve block response matches the cryoneurolysis outcome, which could help personalize pain treatments.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
cryoneurolysis (a procedure using extreme cold to temporarily block nerves)
What this could lead to
If successful, this could help doctors identify which patients will benefit from cryoneurolysis, improving pain management for chronic musculoskeletal pain.
What could go wrong
This is an early observational study with only 50 participants, so results may not apply to everyone. The procedure itself carries risks like nerve damage or incomplete pain relief.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 50 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Jul 2026

An estimate. Start dates often move.

Expected to finish

Aug 2031

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Be over 18 year old * Adults (\> 18y) with either chronic musculoskeletal pain (\> 3 months; average NRS \> 5/10) or painful/functionally limiting spasticity * Have a clinical stable condition, \> 3months * Any medications must be maintained on a stable schedule- Able to understand study instructions and provide informed consent (ICF) in French or Dutch.Provide written informed consent Exclusion Criteria: * Contraindication to cryoneurolysis such as a diagnosis of cryoglobulinemia, paroxysmal cold haemoglobinuria, cold urticaria, Raynaud's disease, any form of peripheral neuropathy, open and or infected wounds of the affected limb * Patient's refusal to give consent to the procedure or to use of their data for research purposes. * Ongoing local or systemic infection before the procedure. * Predominantly neuropathic pain of the upper extremity as assessed with the Pain Detect questionnaire

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Chronic musculoskeletal pain Cryo analgesia Cryoablation Spasticity

How to take part

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  1. The official record

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