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Creatine pills tested for menopause brain fog and fatigue

NCT ID NCT06660004

Symptom relief Sponsor: University of Novi Sad, Faculty of Sport and Physical Education Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested whether taking creatine supplements for 8 weeks could improve fatigue, thinking skills, and brain chemistry in perimenopausal and menopausal women. 36 women took either creatine HCl, creatine ethyl ester, or a placebo. Researchers measured fatigue levels, exercise endurance, brain creatine levels, and cognitive interference. The trial is complete, but results are not yet reported.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
creatine (creatine HCl and creatine ethyl ester)
What this could lead to
If it works, this could point toward a simple dietary supplement to help with fatigue and brain fog during menopause.
What could go wrong
This is a small, early-stage trial with only 36 participants. Results may not apply to all women, and supplements can cause digestive upset or other mild side effects.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

36 people

The number who actually took part.

Started

Nov 2024

Finished

May 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

40 to 65 years

Sex

Female participants only

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Body mass index 18.5 - 29.9 kg/m2 * Free of major chronic diseases or acute disorders (including AD and dementia (MMSE score \> 25 points) * MENOPAUSAL: no menstrual cycle for consecutive 12 months (with no other obvious causes) * PERIMENOPAUSAL: Still menstruating (regular or irregular) but have at least one of the following symptoms: (1) hot flashes, (2) sleep disturbances, (3) mood swings, and (4) concentration difficulties * Given written informed consent Exclusion Criteria: * History of dietary supplement use 4 weeks before the study commences * Pregnancy (or planning pregnancy) * Abnormal values for lab clinical chemistry (\> 2 SD) * Unwillingness to return for follow-up analysis * Participation in other clinical trials

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Conditions

The condition(s) this trial relates to.

Fatigue

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Menopausal Perimenopause

Contacts and locations

Locations

  • FSPE Applied BIoenergetcis Lab

    Novi Sad, Vojvodina, 21000, Serbia

More trials for these conditions

Other studies related to the condition(s) this trial covers.