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NC study tracks COVID-19 antibodies in healthy adults for a year

NCT ID NCT04490174

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study followed 643 healthy adults in central North Carolina for one year to see how many developed antibodies to the COVID-19 virus. Participants had blood drawn five times and completed weekly symptom surveys. The goal was to better understand exposure rates and immune response to inform public health strategies.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

643 people

The number who actually took part.

Started

Aug 2020

Finished

Dec 2023

Lead sponsor

A government research agency

The lead sponsor is the US National Institutes of Health.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Healthy adults \>18 years age without a current active COVID-19 infection or current symptoms consistent with COVID-19 within Central North Carolina.

Ages

18 to 100 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

* INCLUSION CRITERIA: In order to be eligible to participate in this study, an individual must meet all of the following criteria: 1. Male and females 2. greater than or equal to 18 years of age 3. Able to read and speak English 4. Ability to provide informed consent 5. Able to travel to study visits at the NIEHS CRU for required study visits 6. Stated willingness to comply with all study procedures and availability for the duration of the study EXCLUSION CRITERIA: An individual who meets any of the following criteria will be excluded from participation in this study: 1. Current symptoms consistent with COVID-19 infection at the point of Antibody Visit 1 2. Inability to provide a blood sample 3. Current pregnancy or lactation, by participant verbal confirmation. 4. Any condition that, in the investigator's opinion, places the participant at undue risk for complications associated with required study procedures. 5. Not willing to have blood samples stored for future research Participants who have Limited English Proficiency will be excluded from the study because the informed consent form is only available in English. The study documents (Demographic and Health Assessment Questionnaire, and Weekly Symptom Questionnaire) and FDA Fact Sheets for Tests with Emergency Use Authorization are only available in English. Decisionally impaired adults and prisoners will be excluded due to the inability to complete necessary study procedures. Adults who become prisoners or decisionally impaired while on study will be withdrawn. Pregnant women are excluded due to the need to have participants venture out during the COVID-19 pandemic. Women who become pregnant during the study will be withdrawn. Children will be excluded from enrolling in this study as immunity in children is different than adults and we are focusing on adult immunity and in this trial

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Conditions

The condition(s) this trial relates to.

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Locations

  • NIEHS Clinical Research Unit (CRU)

    Research Triangle Park, North Carolina, 27709, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.