Cord blood banked for sickle cell: a step toward future cures

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

* INCLUSION CRITERIA: Pregnant women who are at risk of having an infant or infants (in case of multiple births) with sickle cell disease of the following types: Hemoglobin Sbeta 0 thalassemia Hemoglobin Sbeta + thalassemia Hemoglobin SC Hemoglobin SD Hemoglobin SE Hemoglobin SS Or other sickle-related variant determined acceptable by PI 1. Maternal subjects must be between 18 and 45 years old. 2. Maternal subjects must be able to provide informed consent. 3. Maternal subjects must work with their obstetrician to insure appropriate cord blood collection, sample collection, and completion of related documents. 4. Maternal subjects enrolled on other studies are not excluded, unless the other study may interfere with the present one. EXCLUSION CRITERIA: 1. The maternal subject will not be eligible for study if she is known to be positive for one or more of the following diseases transmissible by blood: HIV, hepatitis B, hepatitis C, WNV, HTLV or ZIKV. 2. Maternal subject will not be eligible for the study if she has active syphilis, toxoplasmosis, malaria or 3. Maternal subject will not be eligible for the study if the pregnancy resulted from egg donation or sperm donation. 4. Maternal subject is unable to give informed consent. 5. Maternal subject is known to have a fetus with a significant congenital anomaly, either not compatible with life, or requiring immediate surgical intervention or care in the Neonatal Intensive Care Unit. 6. Maternal subject has cancer or received treatment for cancer during pregnancy. 7. Infant is premature (\<34 weeks). 8. Maternal subject may be excluded at the time of delivery if the attending physician or collection staff deems that the cord blood collection is inadvisable, due to unanticipated obstetrical complications. 9. Cord blood received by CCBB/STLC is greater than 72 hours from collection