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New drug may reduce Post-Surgery urinary problems

NCT ID NCT05887375

Symptom relief Sponsor: University of Missouri-Columbia Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested two different drugs used to reverse the effects of a muscle relaxant (rocuronium) after elective spine surgery. The goal was to see if one drug (sugammadex) causes less urinary retention (trouble urinating) than the standard combination (neostigmine/glycopyrrolate). 118 adults having outpatient back surgery took part. The results could help doctors choose the best option to reduce this common side effect.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 4

Runs after approval, following long-term safety and how well the treatment works in everyday use.

Participants

118 people

The number who actually took part.

Started

Aug 2023

Finished

Jan 2026

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Age ≥ 18 years * ASA Physical Status I-III Exclusion Criteria: * Inability to obtain written informed consent * Allergy to medications used in the protocol * Known or suspected neuromuscular disorders * Significant renal disease with a serum creatinine ≥ 2 mg/dL * Significant liver disease * A family history of malignant hyperthermia * History of genitourinary surgery, cancer, or radiation within the last year * Currently prescribed urological medications or diuretics * BPH or symptoms of BPH (interrupted or weak urine stream or wake up to urinate more than two times per night) * History or diagnosis of urinary incontinence or urinary retention * History of PONV with use of scopolamine * Use of Foley catheter pre- or intra- operatively * Perioperative medications that influence micturition (e.g., diuretics or intraoperative anticholinergic medication use other than NMB reversal)

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Conditions

The condition(s) this trial relates to.

Urinary Retention

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Reversal of neuromuscular blockade Spine surgery Urinary retention postoperative

Contacts and locations

Locations

  • University Hospital

    Columbia, Missouri, 65212, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.