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Less invasive spine surgery may match traditional fusion for back pain relief

NCT ID NCT07289737

Symptom relief Sponsor: The Fourth Affiliated Hospital of Zhejiang University School of Medicine Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 2 times

Summary

This study compares two types of spine surgery for a condition called degenerative lumbar spondylolisthesis, where a vertebra slips forward and causes pain or nerve problems. One surgery uses a small camera (endoscope) to relieve pressure, while the other involves fusing bones together. Researchers will track 100 patients aged 50-90 to see which approach provides better pain relief and function with fewer complications.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
surgical procedure
What this could lead to
If successful, this could show that a less invasive endoscopic surgery works as well as or better than traditional fusion surgery for relieving pain and improving mobility.
What could go wrong
This is a relatively small study (100 participants) comparing two established procedures, so results may not apply to all patients. Both surgeries carry risks like infection or nerve damage.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 100 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Dec 2025

An estimate. Start dates often move.

Expected to finish

Jun 2030

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Patients with lumbar degenerative spondylolisthesis

Ages

50 to 90 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. Aged between 50 and 90 years old with a confirmed diagnosis of degenerative lumbar spondylolisthesis; 2. Clinical symptoms include chronic pain, nerve compression, or motor dysfunction, confirmed by imaging studies (e.g., MRI or CT); 3. No significant improvement after at least 3 months of conservative treatment (e.g., medication, physical therapy), meeting surgical indications; 4. Understand and consent to the relevant procedures of this study, and sign the informed consent form. Exclusion Criteria: 1. Patients exhibiting acute spinal cord compression symptoms or requiring urgent surgical intervention; 2. Patients with a history of spinal surgery or conditions such as spinal deformities, severe osteoporosis, or active infections that may compromise surgical outcomes; 3. Patients with severe comorbidities affecting assessment, such as cardiovascular disease, liver or kidney failure, or uncontrolled diabetes; 4. Patients with psychiatric disorders or cognitive impairments preventing understanding or cooperation with the study process; 5. Patients with allergies to anesthetics or surgical equipment that may increase intraoperative risks.

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Conditions

The condition(s) this trial relates to.

spondylolisthesis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Lumbar degenerative spondylolisthesis

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • 4th Affiliated Hospital, School of Medicine, Zhejiang University

    RECRUITING

    Yiwu, Zhejiang, 322000, China

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