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Filler Face-Off: sculptra vs radiesse at the genetic level

NCT ID NCT05620043

Knowledge-focused Sponsor: Galderma R&D Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looked at how two different dermal fillers—Sculptra and Radiesse Plus—change gene activity in the skin. Researchers took small skin samples from 21 people after treatment to measure genes related to collagen, elastin, and skin repair. The goal was to understand which filler might better support skin health at a molecular level.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Poly-L-lactic acid (Sculptra) and calcium hydroxylapatite (Radiesse Plus)
What this could lead to
If successful, this could help doctors choose which filler is better for stimulating collagen and skin repair based on genetic markers.
What could go wrong
This is a very small, early study (21 people) looking at gene changes, not actual cosmetic outcomes. Results may not predict real-world effectiveness or apply to everyone.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

21 people

The number who actually took part.

Started

Sep 2022

Finished

Nov 2023

Lead sponsor

A company

The lead sponsor is a pharmaceutical, biotech, or medical-device company.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

22 to 50 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Subject with a minimum of shallow nasolabial fold (NLF) contour deficiencies as assessed via the wrinkle assessment scale * Subject with identical WAS scores on both NLFs * Ability of giving consent for participation in the study * Agreement to have skin biopsies on NLFs Exclusion Criteria: * Significant NLF asymmetry, or different WAS score on each NLF * Pregnant, planning pregnancy during the course of the study or breastfeeding * History of allergy or hypersensitivity to any ingredient of the treatment products * History of allergy or hypersensitivity to anesthetics or lidocaine

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Gene expression

Contacts and locations

Locations

  • Miami Dermatology & Laser Institute

    Miami, Florida, 33173, United States

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