Laser eye surgery showdown: which technique gives the best vision?
NCT ID NCT07201298
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study compares a new type of LASIK (Ray-Tracing Guided) with three other common laser eye surgeries (SMILE, Wavefront Optimized LASIK, and Topography Guided LASIK) to see which one provides the best vision after surgery. Researchers will enroll 120 people with nearsightedness (with or without astigmatism) and follow them for 12 months. The goal is to measure how many people achieve 20/20 vision or better without glasses.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- Laser eye surgery (LASIK and SMILE)
- What this could lead to
- If successful, this could show which laser eye surgery technique gives the sharpest vision with the fewest side effects for nearsighted people.
- What could go wrong
- This is a small, early-phase study (120 people) comparing existing techniques, not testing a new cure. Results may not apply to everyone, and all laser surgeries carry risks like dry eyes or glare.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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About 120 people
The number the study aims to enrol. It can still change while the study runs.
- Expected to start
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Sep 2025
An estimate. Start dates often move.
- Expected to finish
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Sep 2029
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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22 to 50 years
- Sex
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Anyone
- Healthy volunteers
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Accepted
You do not need to have the condition being studied to take part.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: 1. Age 22-50 at the time of consent 2. Diagnosis of myopia or myopia with astigmatism with Preoperative manifest spherical equivalent refraction of ≥ -2.00 and ≤ -9.00 D (-2.00 D through -9.00 D) 3. Preop Spherical component of ≥ -2.00 and ≤ -8.00 D (-2.00 D through -8.00 D) 4. Refractive Cylinder of ≤ -3.00 D (0.00 through -3.00 D) 5. BCVA of 20/20 or better in each eye (83 or more letters on the ETDRS Chart) 6. Subjects must have a stable refraction which is defined as a change in spherical equivalent no greater than 0.50 D comparing the screening visit manifest refraction to a previous refraction, spectacle Rx, or contact lens Rx, 12 months or older. 7. Subjects who are contact lens wearers must discontinue the use of soft lenses (spherical or toric) for at least 5 days and hard or gas-permeable lenses for at least 4 weeks prior to the preoperative screening evaluation. Hard or gas-permeable lens wearers must not return to contact lens use before surgery. Soft lens wearers may resume contact lens wear after all preoperative testing is completed, but must discontinue lens use at least 5 days before surgery. 8. Acceptable preoperative tomography and examination results for refractive procedures as determined by the Principal Investigator. 9. Surgical plan includes treatment target for emmetropia in both eyes, and no monovision. 10. Subject is capable and willing to use postoperative medications as prescribed. 11. Subject has ability to successfully complete all preoperative and postoperative questionnaires, testing, and exam visits. 12. Subject is willing and able to return for all postoperative examinations. Exclusion Criteria: 1. Clinically significant dry eye on clinical examination, as determined by the investigator 2. Irregular astigmatism, keratoconus, keratoconus suspect, or abnormal corneal tomography 3. History of corneal dystrophies or guttata 4. History of herpetic keratitis or active disease 5. History of prior refractive surgery 6. History of glaucoma or glaucoma suspect 7. History of uncontrolled diabetes, unstable hypertension, or unstable autoimmune disease. 8. Females who are pregnant, breastfeeding, or intend to become pregnant any time during the study as determined by verbal inquiry. 9. The Principal Investigator has determined the subject not to be a good candidate for the study.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The places running it
1 site. The list below names each one and where it is.
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The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
Contacts and locations
Locations
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Hoopes Moshirfar Research Center
RECRUITINGDraper, Utah, 84020, United States
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- Lens showdown: which contact lens wins in dim light?
- Myopia glasses may keep working even after kids take them off
- Can glasses that slow nearsightedness also reshape a Child's astigmatism?