Could skipping a key IVF drug make treatment easier and cheaper?
NCT ID NCT06879002
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study compares two approaches to ovarian stimulation for IVF. The standard method uses a drug (GnRH antagonist) to prevent early ovulation. The new method starts stimulation after ovulation, relying on the body's natural progesterone to prevent early ovulation, potentially reducing the number of injections. The study will enroll 252 women aged 18-38 with normal cycles to see if the simpler approach works just as well.
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Study facts
What this study's own registry entry says, in plain language.
- Participants
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About 252 people
The number the study aims to enrol. It can still change while the study runs.
- Expected to start
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Dec 2026
An estimate. Start dates often move.
- Expected to finish
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Dec 2027
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
Who is studied
Expected normal responder patients who undergo IVF/ICSI+PGT-A at ART Fertility Clinics Dubai \& Abu Dhabi are willing to participate in the study.
- Ages
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18 to 38 years
- Sex
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Female participants only
- Healthy volunteers
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Accepted
You do not need to have the condition being studied to take part.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Age 18 to 38 years old. * Normal Menstrual cycle of 25-35 days. * Body Weight 60to90 kg * AMH\>1.3 - \<3 ng/m (Ferraretti and Gianaroli, 2014; Calzada et al., 2019) an antral follicle count (AFC) of \>5 on menstrual cycle days 2-3, Exclusion Criteria: * History of premature ovulation * Azoospermia * PCOS * Endometriosis AFS ¾ * Endometrioma * Known chromosomal abnormalities
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As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The places running it
2 sites. The list below names each one and where it is.
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The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
Contacts and locations
Locations
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ART Fertility Clinics LLC
Abu Dhabi, United Arab Emirates
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ART Fertility Clinics LLC - Dubai
Dubai, United Arab Emirates
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