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New drug combo may speed up emergency intubation

NCT ID NCT05509192

Knowledge-focused Sponsor: The University of Texas Health Science Center, Houston Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested a new method (MTPI) for giving anesthesia drugs to make inserting a breathing tube faster and easier. It involved 154 adults with higher airway risk (e.g., obesity). The goal was to see if MTPI works better than the standard approach.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
rocuronium and propofol
What this could lead to
If successful, this could lead to faster and safer intubation techniques for patients with difficult airways.
What could go wrong
This is a small, completed Phase 4 trial with 154 participants, so results may not apply to all patients. The study focuses on timing and success rates, not long-term outcomes.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 4

Runs after approval, following long-term safety and how well the treatment works in everyday use.

Participants

154 people

The number who actually took part.

Started

Aug 2022

Finished

Jan 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * BMI \>30 kg/M2 or Mallampati class III or IV * Requiring general anesthesia and endotracheal intubation Exclusion Criteria: * Acute and chronic respiratory disorders, including Chronic obstructive pulmonary disease (COPD) and asthma * American Society of Anesthesiologists (ASA) physical status classification \> III * Emergency surgery * Induction requiring cricoid pressure * Patients requiring awake intubation * Pregnant women * Patients who require an induction dose of propofol less than 1 mg/kg * Untreated ischemic heart disease * Contraindication to mask ventilation * Allergy to propofol, rocuronium, or Sugammadex * Induction requiring succinylcholine

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Anesthesia

Contacts and locations

Locations

  • The University of Texas Health Science Center at Houston

    Houston, Texas, 77030, United States

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