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Which flu shot works best for seniors? new study aims to find out

NCT ID NCT02872311

Knowledge-focused Sponsor: Marshfield Clinic Research Foundation Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study looked at how well different licensed flu vaccines trigger an immune response in adults aged 65 to 74. About 179 participants received one of four flu vaccines over two flu seasons, and researchers measured their antibody levels at several time points. The goal was to see which vaccine type provides the strongest and longest-lasting immune protection in this age group.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Influenza vaccines (high-dose, adjuvanted, standard-dose, and recombinant)
What this could lead to
If successful, this could help doctors choose the most effective flu vaccine for older adults, potentially reducing flu-related hospitalizations.
What could go wrong
This is a small, completed study that only measures immune response, not actual prevention of flu illness. Results may not apply to all older adults or other flu seasons.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

179 people

The number who actually took part.

Start date

Sep 2016

Finished

Sep 2018

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

65 to 74 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Age 65-74 years at the time of study enrollment and are ambulatory and live in selected Wisconsin community or surrounding communities. * Willing and able to give informed consent prior to study enrollment * Able to comply with study requirements. Exclusion Criteria: * Prior receipt of 2016-17 influenza vaccine * Current participation in another clinical trial * Presence of a contraindication to influenza vaccine

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Conditions

The condition(s) this trial relates to.

influenza prevention target

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Immune response

Contacts and locations

Locations

  • Marshfield Clinic - Marshfield Center

    Marshfield, Wisconsin, 54449, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.