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Which laxative cleans the colon best? new study aims to find out

NCT ID NCT04598880

Disease control Sponsor: Parc de Salut Mar Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study compared two low-volume laxatives used to clean the colon before a colonoscopy: one liter of polyethylene glycol with ascorbate (PEG1A) and sodium picosulfate with magnesium citrate (PSCM). The goal was to see which one provides a higher quality colon cleansing, which helps doctors find and remove polyps and detect colorectal cancer. Over 1,100 outpatients participated, and the results could improve how patients prepare for colonoscopies.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Polyethylene glycol with ascorbate (PEG1A) and sodium picosulfate with magnesium citrate (PSCM)
What this could lead to
If one laxative proves superior, it could lead to better colon cancer detection and more comfortable preparation for patients.
What could go wrong
This is a completed Phase 4 trial comparing existing drugs, so no major breakthrough is expected. Results may show no significant difference between the two.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 4

Runs after approval, following long-term safety and how well the treatment works in everyday use.

Participants

1,180 people

The number who actually took part.

Started

Nov 2020

Finished

Apr 2024

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 85 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Outpatients with previously scheduled colonoscopy with any indication: screening, follow-up, or symptoms. Exclusion Criteria: * Age less than 18 years or more than 85 years * Hospital admission at the time of colonoscopy * Partial or total colectomy * Severe constipation * Active inflammatory bowel disease * Severe kidney or liver failure * Pregnancy or lactation * Inability to understand the instructions by language barrier or cognitive disorder * Refusal to participate in the study.

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Conditions

The condition(s) this trial relates to.

colonic disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Colonic diseases

Contacts and locations

Locations

  • Clínica Universidad de Navarra

    Madrid, Spain

  • Hospital Costa del Sol

    Marbella, Spain

  • Hospital Germans Trias i Pujol

    Badalona, Spain

  • Hospital Gregorio Marañón

    Madrid, Spain

  • Hospital La Paz

    Madrid, Spain

  • Hospital Quirón

    Málaga, Spain

  • Hospital Ramón y Cajal

    Madrid, Spain

  • Hospital Santa Bárbara

    Soria, Spain

  • Hospital Virgen de las Nieves

    Granada, Spain

  • Hospital de Poniente

    Almería, Spain

  • Hospital de Viladecans

    Viladecans, Barcelona, Spain

  • Hospital de la Princesa

    Madrid, Spain

  • Hospital del Mar

    Barcelona, 08003, Spain

  • Organización Sanitaria Integrada Araba

    Alava, Spain

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