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New study tests safer pain control for teens after spine surgery

NCT ID NCT06096181

Symptom relief Sponsor: Cedars-Sinai Medical Center Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early This study
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looked at two different combinations of anesthesia medicines given through an IV to teenagers having surgery for scoliosis. The goal was to see if one combination leads to less pain and less need for opioid painkillers after surgery. The study was small and ended early, so the findings are limited.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Propofol, Remifentanil, and Dexmedetomidine
What this could lead to
If it works, this could point toward a better way to manage pain after scoliosis surgery in teens, reducing the need for strong painkillers.
What could go wrong
This is a small, early-phase study that was terminated early, so results may not be reliable. Dexmedetomidine is not FDA-approved for children, and the study may not show a clear benefit.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 2

Tests whether the treatment actually works, and watches for side effects, in a larger group.

Participants

13 people

The number who actually took part.

Started

Dec 2023

Finished

Dec 2024

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

12 to 18 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Age 12-18 years old * American Society of Anesthesiology Physical Status Classification (ASA Class) 1 and 2 * Have diagnosis of Adolescent Idiopathic Scoliosis * Undergoing Posterior Spinal Fusion with instrumentation for scoliosis correction * Matched on age, sex, and the number of vertebral levels fused Exclusion Criteria: * Neuromuscular scoliosis * Allergy to any of the multi-modal analgesia regimen drugs * Use of serotonergic drugs, monoamine oxidase inhibitors (MAOI), mixed agonist/antagonist opioid analgesics

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Conditions

The condition(s) this trial relates to.

adolescent idiopathic scoliosis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Adolescent idiopathic scoliosis Dexmedetomidine Multimodal analgesia Opioid induced hyperalgesia Posterior spinal fusion Remifentanil

Contacts and locations

Locations

  • Cedars-Sinai Medical Center

    Los Angeles, California, 90048, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.