Which anesthesia drug wakes you up faster after spine surgery?
NCT ID NCT07443163
First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 2 times
Summary
This study compares two drugs, magnesium sulfate and dexmedetomidine, used alongside total intravenous anesthesia during spine surgery. The goal is to see which drug helps patients wake up and have their breathing tube removed faster. Forty adults scheduled for elective spine surgery will be randomly assigned to receive one of the two drugs. The results could help improve recovery after spine surgery.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- magnesium sulfate and dexmedetomidine
- What this could lead to
- If this trial succeeds, it could help doctors choose the best anesthesia drug for faster recovery after spine surgery.
- What could go wrong
- This is a small early-stage trial with only 40 participants, so results may not apply to everyone. The drugs may also cause side effects like low blood pressure or slow heart rate.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Phase 3
Large-scale testing in a bigger group. Usually the last step before a treatment can be approved.
- Participants
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About 40 people
The number the study aims to enrol. It can still change while the study runs.
- Expected to start
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Mar 2026
An estimate. Start dates often move.
- Expected to finish
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Oct 2026
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 to 65 years
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * American Society of Anesthesiologists (ASA) physical status I, II. * Scheduled for elective spine surgery up to two levels under general anesthesia Exclusion Criteria: * History of preoperative neuromuscular disease, hepatic impairment \[defined as a known diagnosis of liver cirrhosis, hepatitis with elevated liver enzymes (\>2 times upper standard limit), or Child-Pugh score B or C\], renal impairment \[defined as chronic kidney disease with an estimated glomerular filtration rate (eGFR) \<60 mL/min/1.73 m² or history of dialysis\], endocrinal disorders \[including uncontrolled diabetes mellitus (HbA1c \>8.5%), thyroid dysfunction (untreated hypo/hyperthyroidism), or adrenal insufficiency\], hematological disorder \[such as anemia (Hb \<10 g/dL), coagulopathies (INR \>1.5, platelet count \<100,000/mm³), or bleeding diathesis\] or cardiovascular dysfunction \[defined as history of ischemic heart disease, arrhythmias requiring treatment, heart failure (NYHA class II or higher), or uncontrolled hypertension (SBP \>160 mmHg or DBP \>100 mmHg)\]. * Any degree of heart block. * Known allergy to the study drugs. * Scoliosis surgery. * Cervical spine surgeries. * Surgeries with an anticipated duration of more than 4 hours. * Receiving magnesium supplementation. * Any Preoperative Disturbed consciousness level or cognitive dysfunction. * Drugs known to have a significant interaction with NMDAs. * Chronic use of opioids and current treatment with a β-blocker or calcium channel blocker.
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Genom att skicka in godkänner du våra Användarvillkor
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The official record
The full official record for this study. This one lists no contact details, but it is the first place any would appear.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
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