Colon cancer study aims to improve treatment for older patients
NCT ID NCT04416490
First seen Jun 26, 2026 · Last updated Jun 26, 2026
Summary
This study follows over 2,000 Korean patients with stage II or III colon cancer after surgery to see which chemotherapy treatments they actually receive and how they fare. Unlike typical clinical trials, it includes older adults and reflects real-world medical practice. The goal is to gather data that could lead to better, more personalized treatment guidelines.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- What this could lead to
- If successful, this study could help doctors tailor chemotherapy after colon cancer surgery, especially for older patients who are often left out of clinical trials.
- What could go wrong
- This is an observational study, not a treatment trial, so it won't directly test a new drug or cure. Results may not apply outside of Korea.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Participants
-
2,013 people
The number who actually took part.
- Started
-
Mar 2020
- Expected to finish
-
Feb 2027
An estimate. End dates often move.
- Lead sponsor
-
A company
The lead sponsor is a pharmaceutical, biotech, or medical-device company.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
Who is studied
Patients with high-risk stage II or stage III primary colon cancer who have received curative resection. Approximately 2,000 subjects.
- Ages
-
19 years and older
- Sex
-
Anyone
- Healthy volunteers
-
Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: 1. Subjects are given explanations about the study objectives and methods, and will express their consent by signing a written agreement to use their personal information. 2. Male and female adult subjects who are ≥ 19 years old. 3. Subjects are confirmed to have primary colon cancer through histological diagnosis and are at \*high-risk stage II (T3/4, N0M0) or stage III (any T, N1/2, M0). * High-risk stage II is determined when one or more of the following are applicable. 1. Cancer is at T4 stage (stage IIB,IIC); 2. Cancer cell differentiation grade is 3 or 4 (poor histologic grade); 3. Cancer cells are present in lymphatic or blood vessels around the tumor (peritumoral lymphovascular involvement); 4. Ileus was present during surgery (bowel obstruction at presentation); 5. Cancer is at T3 stage with localized perforation or there are indeterminate cancer cells residual on the incisal surface. (T3 lesions with localized perforation or close, indeterminate, or positive margins); or, 6. Cancer cells invaded into the area around the ganglion (perineural invasion). 4. Subjects are decided to require adjuvant chemotherapy including oxaliplatin and/or capecitabine after curative resection (E.g.: FOLFOX, CapeOx or Capecitabine and modified therapies). 5. Subjects' performance status score (ECOG PS) is 2 or lower (0, 1, 2). Exclusion Criteria: 1. Subjects are diagnosed with other primary cancers that can influence the treatment or prognosis of primary rectal and colon cancers. 2. Subjects are diagnosed with relapsed or secondary colon cancer. 3. Subjects with Stage 0/1 (Tis/1/2, N0M0) or Stage IV (any T, any N, M1) colon cancer. 4. Subjects who are currently on adjuvant chemotherapy after curative resection. 5. Subjects who are receiving palliative chemotherapy. 6. Pregnant and breast-feeding subjects. 7. Subjects who are currently participating in other clinical trials (clinical trials for drugs or medical devices) or are planning to participate in other clinical trials during the duration of this study. However, subjects participating in a noninterventional observational study or a registry study can participate in this study. 8. Other subjects who are not suitable for study participation upon the investigator's decision.
Get updates
Get notified about this study
Sign up to get updates when this study changes or when new studies for Stage II colon cancer are added.
Genom att skicka in godkänner du våra Användarvillkor
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Yonsei University Health System, Severance Hospital
Seoul, South Korea
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- Blood test may spot colon cancer return months before scans
- Can a simple blood test tell who needs more cancer treatment?
- Can adding cetuximab to chemotherapy prevent colon cancer return?
- Can an arthritis drug boost chemo for colon cancer?
- Blood test may spare some colon cancer patients from chemo
- New genetic test may predict colon cancer return