Can brain training ease 'Chemo Brain' in gynecologic cancer survivors?

NCT ID NCT06662435

Symptom relief Sponsor: Northwestern University Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tested a home-based cognitive training program called BrainHQ in 60 women with gynecologic cancers who had memory or thinking problems after chemotherapy. Participants used the app for about 2.5 hours per week for 10 weeks. The goal was to see if the program was practical and acceptable, not yet to prove it works.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance: BrainHQ cognitive training app
What this could lead to: If it works, this could offer a practical way to improve thinking and memory problems after cancer treatment.
What could go wrong: This is a small pilot study focused on feasibility, not effectiveness. The program may not help everyone, and results may not apply to all patients.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

60 people

The number who actually took part.

Started

Feb 2025

Finished

Mar 2026

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Female participants only

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Female; ≥18 years of age * Presents to clinic with a confirmed diagnosis of a gynecologic cancer (e.g., ovarian, endometrial, cervical, or vulvar cancer) who have completed adjuvant chemotherapy with at least stable disease at time of screening. * Screen positive for subjective cognitive impairment by answering affirmatively to at least one of three screener questions * Fluent in spoken and written English * Have access to the internet to complete assessments Exclusion Criteria: * Patients who have not received chemotherapy * Patients with pre-existing neuropsychiatric disorders that would impact cognitive function, such as dementia, Alzheimer's disease, and schizophrenia. * Patients with non-gynecologic causes of incurable metastatic cancers. * Patients undergoing active interventions in other cognitive trials or patients currently using cognitive training programs such as Brain HQ, Luminosity, Elevate, Peak, Fit Brains, or CogniFit. * Patients with self-report of learning disability or an unwillingness to participate in technology-based cognitive training programs. * Pregnant women or prisoners * Patients with impaired-decision making capacity

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Conditions

The condition(s) this trial relates to.

cervical cancer cervical carcinoma Cognitive Dysfunction endometrial cancer endometrium neoplasm ovarian cancer uterine cancer Uterine Cervical Neoplasms vulva cancer

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Cervical cancers Cervix cancer Endometrial cancer Ovarian cancer Ovary cancer Uterine cancer Vulvar cancers

Can brain training ease 'Chemo Brain' in gynecologic cancer survivors?

What the study statuses mean