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Brain training after hospital delirium shows promise for older adults

NCT ID NCT04740567

Disease control Sponsor: Vanderbilt University Medical Center Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tested whether early cognitive training and rehabilitation can improve long-term thinking skills in older adults (65+) who experienced delirium during a hospital stay. 283 participants were randomly assigned to receive either the cognitive training program or usual care. The training included daily exercises during hospitalization and weekly sessions for 12 weeks after discharge, focusing on memory, attention, and problem-solving. The main goal was to see if this approach improved global cognition four months later.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
cognitive training and rehabilitation (behavioral intervention)
What this could lead to
If it works, this could point toward a simple, drug-free way to help older adults recover their thinking skills after a hospital stay with delirium.
What could go wrong
This is a single completed study with 283 participants. The results may not apply to everyone, and the benefits might be small or not last long.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

283 people

The number who actually took part.

Started

Feb 2021

Finished

Nov 2024

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

65 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * 65 years or older * Admitted through the ED * Cognitive training can be initiated within 24 hours of ED presentation * Delirious at enrollment Exclusion Criteria: * Comatose * Not able to follow simple commands or non-verbal prior to the acute illness (end-stage pre-illness ADRD) * Resides in a nursing home * Prisoner * Receiving hospice care * Lives \> 100 miles away from the enrolling sites * Non-English speaking * Previously enrolled * Deaf or blind * Intravenous drug, crack or cocaine, or methamphetamine use within the past one year, or any condition that, in the investigator's opinion, makes them an unreliable trial patient or unlikely to complete the trial. * Psychotic disorder or suicidal gesture requiring hospitalization with the past one year * Discharged from the ED

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Conditions

The condition(s) this trial relates to.

Cognitive Dysfunction delirium dementia

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Cognitive decline Delirium Dementia

Contacts and locations

Locations

  • Tennessee Valley Healthcare System - Nashville Veteran Affairs Hospital

    Nashville, Tennessee, 37027, United States

  • Vanderbilt University Medical Center

    Nashville, Tennessee, 37027, United States

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