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Brain training for long COVID: new study tests remote coaching

NCT ID NCT06136871

Symptom relief Sponsor: University of Missouri-Columbia Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tested whether a remote cognitive strategy training program (CO-OP) is feasible for people with Post-COVID syndrome who have memory or thinking problems. 65 participants learned a step-by-step problem-solving method (Goal-Plan-Do-Check) to improve daily activities. The trial focused on whether the program was acceptable and usable, and also measured effects on thinking and quality of life.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Cognitive strategy training (CO-OP)
What this could lead to
If it works, this could offer a practical way to help people with Post-COVID brain fog manage everyday tasks better.
What could go wrong
This is a small feasibility study, not a large trial. It tests whether the approach is practical, not whether it definitely works. Results may not apply to everyone.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

65 people

The number who actually took part.

Started

Feb 2024

Finished

Jun 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 60 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * self-reported cognitive symptoms persisting for at least 6 weeks following COVID-19 infection (Cognitive Failures Questionnaire (CFQ) score \>43) * self-identified activity performance goals per the Canadian Occupational Performance Measure (COPM) * documented prior diagnosis of COVID-19 * read, write, and speak English fluently * ability to provide valid informed electronic consent Exclusion Criteria: * diagnosis of severe neurological or psychiatric condition(s) * dementia symptoms as indicated by a score of \<23 on the Montreal Cognitive Assessment (MoCA) * untreated sleep apnea (≥5 on the STOPBANG) * prior cancer treatment * severe depressive symptoms (\>21 on the Patient Health Questionnaire-9)

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Conditions

The condition(s) this trial relates to.

COVID-19 long COVID-19 post-COVID-19 disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Post-COVID-19 syndrome

Contacts and locations

Locations

  • University of Missouri Department of Occupational Therapy

    Columbia, Missouri, 65211, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.