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Can a common supplement tame Drug-Resistant epilepsy?

NCT ID NCT07537283

Disease control Sponsor: National Cheng-Kung University Hospital Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested whether taking coenzyme Q10, a natural supplement, can help reduce seizures in adults with drug-resistant epilepsy. Thirty-nine participants took either coenzyme Q10 or a placebo daily for 12 weeks alongside their usual seizure medications. Researchers tracked seizure frequency and cognitive function to see if the supplement made a difference.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
coenzyme Q10
What this could lead to
If it works, this could point toward a safe, natural supplement to help control seizures in people whose epilepsy doesn't respond to standard drugs.
What could go wrong
This is a small, completed trial with only 39 participants, so results may not apply to everyone. Coenzyme Q10 is generally safe, but it may not reduce seizures for all patients.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

39 people

The number who actually took part.

Started

Feb 2023

Finished

Nov 2023

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

20 to 80 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Adults aged 20 to 80 years. * Diagnosed with drug-resistant epilepsy. * Receiving stable anti-seizure medications for at least 4 weeks prior to enrollment. * Able to provide informed consent. * Willing and able to maintain seizure diaries throughout the study period. Exclusion Criteria: * History of progressive neurological disease. * Severe systemic illness (e.g., uncontrolled cardiovascular, hepatic, or renal disease). * Use of coenzyme Q10 or other mitochondrial supplements within 4 weeks prior to enrollment. * Pregnancy or breastfeeding. * Known allergy or hypersensitivity to coenzyme Q10. * Participation in another clinical trial within the past 3 months.

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Conditions

The condition(s) this trial relates to.

Drug Resistant Epilepsy epilepsy

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Drugs resistance Epilepsy

Contacts and locations

Locations

  • National Cheng Kung University Hospital

    Tainan, 704, Taiwan

More trials for these conditions

Other studies related to the condition(s) this trial covers.