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AI tool could unmask hidden cancers in blood clot patients

NCT ID NCT07310693

Knowledge-focused Sponsor: Infanta Leonor University Hospital Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study is testing a computer model called the CLOVER score, which uses machine learning to predict whether a person with a blood clot might have an undiagnosed cancer. Researchers will check the model's accuracy in 500 patients over two years. If it works well, doctors could use it to decide who needs extra cancer screening.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If successful, this could give doctors a reliable way to identify which blood-clot patients need cancer screening, potentially catching hidden cancers earlier.
What could go wrong
This is an observational validation study, not a treatment trial. The model may not perform as well in real-world settings, and it won't directly benefit participants.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 500 people

The number the study aims to enrol. It can still change while the study runs.

Started

Dec 2025

Expected to finish

Dec 2028

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Adults (≥18 years) with objectively confirmed symptomatic venous thromboembolism (deep vein thrombosis or pulmonary embolism) who are consecutively recruited in participating hospitals in Spain. All participants undergo routine clinical evaluation, laboratory testing, and age- and sex-appropriate cancer screening according to standard practice. The population represents real-world patients with new-onset VTE without known or suspected cancer at baseline.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Age ≥18 years. * Objectively confirmed acute symptomatic venous thromboembolism (deep vein thrombosis and/or pulmonary embolism). * Ability to provide written or electronic informed consent. Exclusion Criteria: * Suspicion of cancer during the initial diagnostic evaluation for VTE. * Participation in another interventional study that may interfere with outcomes. * Inability or refusal to provide informed consent.

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Conditions

The condition(s) this trial relates to.

cancer of unknown primary site venous thromboembolism

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Occult cancer Venous thromboembolism (VTE)

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    12 sites. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Hospital Clínic

    RECRUITING

    Barcelona, Barcelona, Spain

  • Hospital Clínico Universitario Virgen de la Arrixaca

    RECRUITING

    Murcia, Murcia, Spain

  • Hospital San Agustín

    RECRUITING

    Avilés, Principality of Asturias, Spain

  • Hospital Universitario 12 de Octubre

    RECRUITING

    Madrid, Spain

  • Hospital Universitario Infanta Leonor

    RECRUITING

    Madrid, Madrid, 28051, Spain

  • Hospital Universitario La Paz

    RECRUITING

    Madrid, Madrid, 28051, Spain

  • Hospital Universitario Morales Meseguer

    RECRUITING

    Murcia, Murcia, Spain

  • Hospital Universitario Príncipe de Asturias

    RECRUITING

    Madrid, Madrid, 28051, Spain

  • Hospital Universitario Son Llatzer

    RECRUITING

    Balea, Spain

  • Hospital Universitario de Fuenlabrada

    RECRUITING

    Madrid, Spain

  • Hospital Universitario de Móstoles

    RECRUITING

    Madrid, Madrid, Spain

  • Hospital Universitatio del Sureste

    RECRUITING

    Madrid, Madrid, 28051, Spain

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