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Clear aligners vs. braces: which is safer for your health?

NCT ID NCT06685029

Knowledge-focused Sponsor: Ahmet Yağcı Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looked at whether clear aligners (like Invisalign) release chemicals called bisphenol A (BPA) into saliva, which can affect hormones. Researchers compared three groups: aligners made by an orthodontist, standard aligners, and traditional braces. They measured BPA levels in 52 teenagers and young adults, and also checked how well each treatment worked. The goal is to help patients and doctors choose the safest option.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

52 people

The number who actually took part.

Started

Oct 2023

Finished

Feb 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

15 to 24 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Absence of primary teeth in the oral cavity, with permanent teeth fully erupted, * Presence of a non-extraction orthodontic treatment plan, * Age range of 15 to 24 years, * Presence of mild to moderate dental crowding (0-6 mm of crowding), * Classification as skeletal Class I (ANB: 2±2°), * Absence of any craniofacial anomalies, * Normal vertical growth pattern (Sn-GoGn: 32±6°), * No congenital tooth agenesis (excluding third molars), * Absence of atypical tooth morphology, * No extracted permanent teeth, * Absence of dental caries, * Good level of oral hygiene, * Healthy periodontal tissues. Exclusion Criteria: * Presence of any systemic disease, * History of previous fixed orthodontic treatment, * History of allergy to any dental material, * Use of medications containing estrogen analogs, * Patients with a history of xerostomia and a salivary flow rate of less than 0.1 ml per minute, * Patients with more than five composite restorations.

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Endocrine disruptors

Contacts and locations

Locations

  • Erciyes University,Faculty of Dentistry,Department of Orthodontics

    Kayseri, 38000, Turkey (Türkiye)

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