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Simple wound wash could slash surgery infections, major trial hints

NCT ID NCT04548661

Disease control Sponsor: Sunnybrook Health Sciences Centre Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested whether washing surgical incisions with an antiseptic (povidone-iodine) or salt water before closing them can prevent infections. Over 2,700 adults having abdominal or groin surgery were randomly assigned to one of three groups: irrigation with povidone-iodine, irrigation with saline, or no irrigation. The main goal was to see if either irrigation method reduced surgical site infections within 30 days. If effective, this simple step could become a standard practice worldwide.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
povidone-iodine solution
What this could lead to
If it works, this simple, low-cost step could become standard practice to prevent surgical site infections, benefiting millions of patients.
What could go wrong
The trial is completed but results are not yet widely known. The effect may be small or not apply to all surgeries. Infection rates depend on many factors.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

2,701 people

The number who actually took part.

Started

Aug 2023

Finished

Sep 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

All participants must meet all of the following inclusion criteria to participate in this study: 1. Aged 18 years or older; 2. Ontario Health Insurance Plan (OHIP) holder (for Ontario sites) And planned to undergo any one of the following surgical procedures: 3. a) Laparotomy, CDC Class II (clean-contaminated) or III (contaminated) incision b) Laparoscopy with a planned extraction site ≥3 cm, CDC Class II (clean-contaminated) or III (contaminated) incision c) Groin incision for open or hybrid arterial procedure All participants meeting any of the following exclusion criteria at baseline will be excluded from participation in this study: 1. Contraindication to receiving povidone-iodine irrigation (i.e., known allergy) 2. Any active skin or soft tissue infection (at any site, including gangrene) 3. Known or anticipated CDC Class IV (Dirty) incision

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Conditions

The condition(s) this trial relates to.

Surgical Wound Infection

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Surgical site infection

Contacts and locations

Locations

  • Hamilton Health Sciences - Juravinski Hospital

    Hamilton, Ontario, Canada

  • Health Sciences North

    Greater Sudbury, Ontario, P3E 5J1, Canada

  • Kingston Health Sciences Centre

    Kingston, Ontario, Canada

  • London Health Sciences Centre

    London, Ontario, Canada

  • Mackenzie Health

    Richmond Hill, Ontario, Canada

  • North York General Hospital

    North York, Ontario, M2K 1E1, Canada

  • Royal Victoria Regional Health Centre

    Barrie, Ontario, Canada

  • Shared Health Manitoba

    Winnipeg, Manitoba, R3A 1R9, Canada

  • St. Joseph's Health Centre

    Toronto, Ontario, Canada

  • St. Michael's Hospital

    Toronto, Ontario, Canada

  • Sunnybrook Health Sciences Centre

    Toronto, Ontario, M4N 3M5, Canada

  • The Ottawa Hospital

    Ottawa, Ontario, K1H 8L6, Canada

  • Thunder Bay Regional Health Sciences Centre

    Thunder Bay, Ontario, Canada

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