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Weekly chemo may be gentler for head and neck cancer patients

NCT ID NCT05050162

Disease control Sponsor: NRG Oncology Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused This study
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study compares two ways of giving the chemotherapy drug cisplatin alongside radiation for people with advanced head and neck cancer. One group gets a high dose every three weeks, the other gets a lower dose weekly. The goal is to see if the weekly schedule causes fewer side effects while still helping patients live as long. The trial was suspended and aims to enroll over 1,700 participants.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Cisplatin (a chemotherapy drug)
What this could lead to
If successful, this could show that a weekly low-dose cisplatin regimen is easier to tolerate and just as effective as the standard every-3-weeks schedule for advanced head and neck cancer.
What could go wrong
This trial is suspended, and it compares two existing treatments rather than testing a new drug. The weekly schedule may not be as effective in controlling the cancer long-term.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 2/3

Runs two stages together: whether the treatment works, then large-scale confirmation.

Participants

About 1,714 people

The number the study aims to enrol. It can still change while the study runs.

Started

Feb 2022

Expected to finish

Feb 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Pathologically (histologically or cytologically) proven diagnosis of SCCHN of the oropharynx, larynx, hypopharynx, or p16-positive unknown primary prior to registration; specimen from cervical lymph nodes with a well-defined primary site documented clinically or radiologically is acceptable; in patients with carcinoma of unknown primary this will be sufficient for pathologic confirmation without a clinically or radiographically defined primary site * For patients with oropharyngeal cancer (OPC)/cancer of unknown primary (CUP): P16 status based on local site immunohistochemical tissue staining is required. A cell block obtained from a fine needle aspiration (FNA) biopsy specimen may be used as the sole diagnostic tissue. Centers are encouraged to contact the pathology chair for clarification. * Note: Institutions must screen patients for p16 status by immunohistochemistry (IHC) in order to be eligible for the trial using a Clinical Laboratory Improvement Amendments (CLIA)-certified laboratory. A rigorous laboratory accreditation process similar to the United States (U.S.) CLIA certification, such as the provincial accreditation status offered by the Ontario Laboratory Accreditation (OLA) Program in Canada, the College of American Pathologists (CAP), or an equivalent accreditation in other countries, is acceptable. * The p16 results must be reported on the pathology report being submitted. The p16 positivity is defined as \> 70% of tumor cells showing strong nuclear and/or cytoplasmic immunostaining with p16 antibody. * For patients with laryngeal and hypopharyngeal primaries: Analysis of p16 status is NOT required. * Patients must have clinically or radiographically evident measurable disease at the primary site or at nodal stations. Simple tonsillectomy or local excision of the primary without removal of nodal disease is permitted, as is excision removing gross nodal disease but with intact primary site. Limited neck dissections retrieving =\< 4 nodes are permitted and considered as non-therapeutic nodal excisions * Clinical stage (American Joint Committee on Cancer \[AJCC\], 8th ed.), including no distant metastases based on the following diagnostic workup: * History/physical examination within 60 days prior to registration * One of the following imaging studies is required within 60 days prior to registration: * Computed tomography (CT) scan of neck (diagnostic quality with contrast, unless contraindicated) OR * Magnetic resonance imaging (MRI) of the neck (diagnostic quality with contrast, unless contraindicated) OR * Fludeoxyglucose F-18 (FDG)-positron emission tomography (PET)/CT of the neck; the CT component must be of diagnostic quality with contrast, unless contraindicated. * Note: A diagnostic quality CT or MRI with contrast or FDG-PET/CT scan of neck performed for the purposes of radiation planning may serve as both staging and planning tools * One of the following imaging studies is required within 60 days prior to registration: * FDG-PET/CT of the chest; FDG-PET/CT scan is strongly preferred and highly recommended to be used for eligibility OR * Chest CT * Exam with laryngopharyngoscopy (mirror or in office direct procedure acceptable) within 70 days prior to registration; * Eligibility by patient cohort; * Non-OPC/p16-negative OPC Cohort; Tumor Site: Larynx/Hypopharynx; Clinical Staging (AJCC, 8th ed.): T3-4 N0 or T1-4 N1-3 T2 N0 (hypopharynx only) * Tumor Site: p16-negative OPC; Clinical Staging (AJCC, 8th ed.): T2N1, T1-4 N2-3, or T3-4 N0-1 * p16-positive OPC/CUP Cohort; * Tumor Site: OPC; Smoking Status: =\< 10 pack-years; Clinical Staging (AJCC, 8th ed.): T1-3 N2-3 or T4 N0-3 * Tumor Site: OPC; Smoking Status: \> 10 pack-years; Clinical Staging (AJCC, 8th ed.): T1N2-3, T2N1-3, or T3-4 N0-3 * Tumor Site: CUP; Smoking Status: Any; Clinical Staging (AJCC, 8th ed.): T0 N2-3 Note: Cigar and pipe tobacco consumption is not included in calculating the lifetime pack-years. Marijuana consumption is likewise not considered in this calculation. There is also no clear scientific evidence regarding the role of chewing tobacco-containing products in oropharyngeal cancer, although this is possibly more concerning given the proximity of the oral cavity and oropharynx. In any case, investigators should not count use of non-cigarette tobacco products in the pack-years calculation. * Age \>= 18 * Zubrod (Eastern Cooperative Oncology Group \[ECOG\]) performance status of 0-1 within 14 days prior to registration * Absolute neutrophil count (ANC) \>= 1,500 cells/mm\^3 (within 30 days prior to registration) * Platelets \>= 75,000 cells/mm\^3 (within 30 days prior to registration) * Hemoglobin \>= 8.0 g/dL (within 30 days prior to registration) * Note: The use of transfusion or other intervention to achieve hemoglobin \[Hgb\] \>= 8.0 g/dL is acceptable) * Calculated creatinine clearance (CrCl) \>= 50 mL/min by the Cockcroft-Gault formula (within 30 days prior to registration) * Total bilirubin =\< 1.5 x institutional upper limit of normal (ULN) (within 30 days prior to registration) (not applicable to patients with known Gilbert's syndrome) * Aspartate aminotransferase (AST) and alanine aminotransferase (ALT) =\< 1.5 x institutional ULN (within 30 days prior to registration) * Known human immunodeficiency virus (HIV) infected patients on effective anti-retroviral therapy with undetectable viral load within 6 months and CD4 T Cell count \> 200 cells/mm\^3 are eligible for this trial. Testing is not required for entry into protocol * Patients with a prior or concurrent malignancy whose natural history or treatment does not have the potential to interfere with the safety or efficacy assessment of the investigational regimen are eligible for this trial * Negative urine or serum pregnancy test (in persons of childbearing potential) within 14 days prior to registration. Childbearing potential is defined as any person who has experienced menarche and who has not undergone surgical sterilization (hysterectomy or bilateral oophorectomy) or who is not postmenopausal. Menopause is defined clinically as 12 months of amenorrhea in a woman over 45 in the absence of other biological or physiological causes * Willing to use highly effective contraceptives for participants of childbearing potential (participants who may become pregnant or who may impregnate a partner) during therapy and for 14 months (females); for 11 months (males) following last dose of cisplatin; this inclusion is necessary because the treatment in this study may be significantly teratogenic. * The patient or a legally authorized representative must provide study-specific informed consent prior to study entry and, for patients treated in the United States (U.S.), authorization permitting release of personal health information Exclusion Criteria: * Patients with oral cavity cancer, nasopharynx cancer, or p16-negative cancer of unknown primary (CUP) * Recurrence of the study cancer * Definitive clinical or radiologic evidence of distant metastatic disease * Prior systemic chemotherapy for the study cancer; note that prior chemotherapy for a different cancer is allowable, however, any prior exposure to cisplatin is excluded * Prior radiotherapy to the region of the study cancer that would result in overlap of radiation therapy fields * Severe, active co-morbidity defined as follows: * Unstable angina requiring hospitalization in the last 6 months * Myocardial infarction within the last 6 months * New York Heart Association Functional Classification III/IV (Note: Patients with known history or current symptoms of cardiac disease, or history of treatment with cardiotoxic agents, should have a clinical risk assessment of cardiac function using the New York Heart Association Functional Classification.) * Persistent grade 3-4 (CTCAE version 5.0) electrolyte abnormalities that cannot be reversed despite replacement as indicated by repeat testing * Patient must not have an active infection requiring IV antibiotics prior to registration; * Other chronic renal disease like nephrotic syndrome, that could be worsened by cisplatin therapy * History of allogenic organ transplantation * Any symptomatic peripheral sensory neuropathy grade \>= 2 (CTCAE version 5.0); * Pregnancy and individuals unwilling to discontinue nursing * History of hypersensitivity to cisplatin or platinum-containing compounds

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Conditions

The condition(s) this trial relates to.

carcinoma head and neck squamous cell carcinoma hypopharynx squamous cell carcinoma laryngeal squamous cell carcinoma oropharyngeal carcinoma oropharynx cancer oropharynx squamous cell carcinoma skin squamous cell carcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Advanced head and neck squamous cell carcinoma Advanced hypopharyngeal squamous cell carcinoma Advanced laryngeal squamous cell carcinoma Advanced oropharyngeal squamous cell carcinoma Clinical stage III HPV-mediated (P16-positive) oropharyngeal carcinoma ajcc V8 Clinical stage IV HPV-mediated (P16-positive) oropharyngeal carcinoma ajcc V8 Stage III head and neck cutaneous squamous cell carcinoma ajcc V8 Stage III oropharyngeal (P16-negative) carcinoma ajcc V8 Stage IV head and neck cutaneous squamous cell carcinoma ajcc V8 Stage IV oropharyngeal (P16-negative) carcinoma ajcc V8

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    370 sites in 5 countries. The list below names each one and where it is.

  2. The official record

    The full official record for this study. This one lists no contact details, but it is the first place any would appear.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • AdventHealth Littleton

    Littleton, Colorado, 80122, United States

  • AdventHealth Parker

    Parker, Colorado, 80138, United States

  • AdventHealth Porter

    Denver, Colorado, 80210, United States

  • Allan Blair Cancer Centre

    Regina, Saskatchewan, S4T 7T1, Canada

  • Allegheny General Hospital

    Pittsburgh, Pennsylvania, 15212, United States

  • Allegiance Health

    Jackson, Michigan, 49201, United States

  • Alta Bates Summit Medical Center-Herrick Campus

    Berkeley, California, 94704, United States

  • American Fork Hospital / Huntsman Intermountain Cancer Center

    American Fork, Utah, 84003, United States

  • Aspirus Cancer Care - James Beck Cancer Center

    Rhinelander, Wisconsin, 54501, United States

  • Aspirus Cancer Care - Stevens Point

    Stevens Point, Wisconsin, 54481, United States

  • Aspirus Cancer Care - Wisconsin Rapids

    Wisconsin Rapids, Wisconsin, 54494, United States

  • Aspirus Regional Cancer Center

    Wausau, Wisconsin, 54401, United States

  • Atrium Medical Center-Middletown Regional Hospital

    Franklin, Ohio, 45005-1066, United States

  • Augusta University Medical Center

    Augusta, Georgia, 30912, United States

  • Avera Cancer Institute

    Sioux Falls, South Dakota, 57105, United States

  • BJC Outpatient Center at Sunset Hills

    Sunset Hills, Missouri, 63127, United States

  • Baptist Cancer Center-Grenada

    Grenada, Mississippi, 38901, United States

  • Baptist Memorial Hospital and Cancer Center-Collierville

    Collierville, Tennessee, 38017, United States

  • Baptist Memorial Hospital and Cancer Center-Desoto

    Southhaven, Mississippi, 38671, United States

  • Baptist Memorial Hospital and Cancer Center-Golden Triangle

    Columbus, Mississippi, 39705, United States

  • Baptist Memorial Hospital and Cancer Center-Memphis

    Memphis, Tennessee, 38120, United States

  • Baptist Memorial Hospital and Cancer Center-Oxford

    Oxford, Mississippi, 38655, United States

  • Baptist Memorial Hospital and Cancer Center-Union County

    New Albany, Mississippi, 38652, United States

  • Bay Pines VA Healthcare System

    Bay Pines, Florida, 33744, United States

  • Baylor College of Medicine/Dan L Duncan Comprehensive Cancer Center

    Houston, Texas, 77030, United States

  • Ben Taub General Hospital

    Houston, Texas, 77030, United States

  • Benefis Sletten Cancer Institute

    Great Falls, Montana, 59405, United States

  • Bozeman Health Deaconess Hospital

    Bozeman, Montana, 59715, United States

  • Broadlawns Medical Center

    Des Moines, Iowa, 50314, United States

  • Bryn Mawr Hospital

    Bryn Mawr, Pennsylvania, 19010, United States

  • Cancer Care Center of O'Fallon

    O'Fallon, Illinois, 62269, United States

  • Cancer Care Specialists of Illinois - Decatur

    Decatur, Illinois, 62526, United States

  • Carle Cancer Center

    Urbana, Illinois, 61801, United States

  • Carle Physician Group-Effingham

    Effingham, Illinois, 62401, United States

  • Carle Physician Group-Mattoon/Charleston

    Mattoon, Illinois, 61938, United States

  • Carle at The Riverfront

    Danville, Illinois, 61832, United States

  • Case Western Reserve University

    Cleveland, Ohio, 44106, United States

  • Cedars-Sinai Medical Center

    Los Angeles, California, 90048, United States

  • Central Maryland Radiation Oncology in Howard County

    Columbia, Maryland, 21044, United States

  • Centralia Oncology Clinic

    Centralia, Illinois, 62801, United States

  • Chelsea Hospital

    Chelsea, Michigan, 48118, United States

  • Cleveland Clinic Cancer Center Mansfield

    Mansfield, Ohio, 44906, United States

  • Cleveland Clinic Cancer Center Strongsville

    Strongsville, Ohio, 44136, United States

  • Cleveland Clinic Cancer Center/Fairview Hospital

    Cleveland, Ohio, 44111, United States

  • Cleveland Clinic Foundation

    Cleveland, Ohio, 44195, United States

  • Cleveland Clinic Wooster Family Health and Surgery Center

    Wooster, Ohio, 44691, United States

  • Coborn Cancer Center at Saint Cloud Hospital

    Saint Cloud, Minnesota, 56303, United States

  • CoxHealth South Hospital

    Springfield, Missouri, 65807, United States

  • Crossroads Cancer Center

    Effingham, Illinois, 62401, United States

  • Dartmouth Cancer Center - North

    Saint Johnsbury, Vermont, 05819, United States

  • Dartmouth Hitchcock Medical Center/Dartmouth Cancer Center

    Lebanon, New Hampshire, 03756, United States

  • Dayton Physician LLC - Englewood

    Dayton, Ohio, 45415, United States

  • Dayton Physicians LLC-Atrium

    Franklin, Ohio, 45005, United States

  • Dayton Physicians LLC-Miami Valley South

    Centerville, Ohio, 45459, United States

  • Decatur Memorial Hospital

    Decatur, Illinois, 62526, United States

  • Drexel Town Square Health Center

    Oak Creek, Wisconsin, 53154, United States

  • Edward Hines Jr VA Hospital

    Hines, Illinois, 60141, United States

  • Edward Hospital/Cancer Center

    Naperville, Illinois, 60540, United States

  • Elmhurst Memorial Hospital

    Elmhurst, Illinois, 60126, United States

  • FHCC Overlake

    Bellevue, Washington, 98004, United States

  • FHCC at EvergreenHealth

    Kirkland, Washington, 98034, United States

  • FHCC at Northwest Hospital

    Seattle, Washington, 98133, United States

  • FirstHealth of the Carolinas-Moore Regional Hospital

    Pinehurst, North Carolina, 28374, United States

  • Forbes Hospital

    Monroeville, Pennsylvania, 15146, United States

  • Fox Chase Cancer Center

    Philadelphia, Pennsylvania, 19111, United States

  • Fred Hutchinson Cancer Center

    Seattle, Washington, 98109, United States

  • Freeman Health System

    Joplin, Missouri, 64804, United States

  • Fremont - Rideout Cancer Center

    Marysville, California, 95901, United States

  • Fresno Cancer Center

    Fresno, California, 93720, United States

  • Froedtert Menomonee Falls Hospital

    Menomonee Falls, Wisconsin, 53051, United States

  • Froedtert West Bend Hospital/Kraemer Cancer Center

    West Bend, Wisconsin, 53095, United States

  • Gene Upshaw Memorial Tahoe Forest Cancer Center

    Truckee, California, 96161, United States

  • Genesys Hurley Cancer Institute

    Flint, Michigan, 48503, United States

  • George Washington University Medical Center

    Washington D.C., District of Columbia, 20037, United States

  • Glens Falls Hospital

    Glens Falls, New York, 12801, United States

  • Greater Regional Medical Center

    Creston, Iowa, 50801, United States

  • Gulfport Memorial Hospital

    Gulfport, Mississippi, 39502, United States

  • Gundersen Lutheran Medical Center

    La Crosse, Wisconsin, 54601, United States

  • HSHS Saint Elizabeth's Hospital

    O'Fallon, Illinois, 62269, United States

  • Henry Ford Cancer Institute-Downriver

    Brownstown, Michigan, 48183, United States

  • Henry Ford Health Providence Novi Hospital

    Novi, Michigan, 48374, United States

  • Henry Ford Health Providence Southfield Hospital

    Southfield, Michigan, 48075, United States

  • Henry Ford Health Saint John Hospital

    Detroit, Michigan, 48236, United States

  • Henry Ford Health Warren Hospital

    Warren, Michigan, 48093, United States

  • Henry Ford Hospital

    Detroit, Michigan, 48202, United States

  • Henry Ford Macomb Hospital-Clinton Township

    Clinton Township, Michigan, 48038, United States

  • Henry Ford Medical Center-Columbus

    Novi, Michigan, 48377, United States

  • Henry Ford Medical Center-Fairlane

    Dearborn, Michigan, 48126, United States

  • Henry Ford West Bloomfield Hospital

    West Bloomfield, Michigan, 48322, United States

  • Hi-Line Sletten Cancer Center

    Havre, Montana, 59501, United States

  • Highland Hospital

    Rochester, New York, 14620, United States

  • Hillcrest Hospital Cancer Center

    Mayfield Heights, Ohio, 44124, United States

  • Houston Methodist Cypress Hospital

    Cypress, Texas, 77429, United States

  • Houston Methodist Hospital

    Houston, Texas, 77030, United States

  • Houston Methodist Saint John Hospital

    Nassau Bay, Texas, 77058, United States

  • Houston Methodist San Jacinto Hospital

    Baytown, Texas, 77521, United States

  • Houston Methodist Sugar Land Hospital

    Sugar Land, Texas, 77479, United States

  • Houston Methodist The Woodlands Hospital

    The Woodlands, Texas, 77385, United States

  • Houston Methodist West Hospital

    Houston, Texas, 77094, United States

  • Huntsman Cancer Institute/University of Utah

    Salt Lake City, Utah, 84112, United States

  • Hurley Medical Center

    Flint, Michigan, 48503, United States

  • Illinois CancerCare - Washington

    Washington, Illinois, 61571, United States

  • Illinois CancerCare-Bloomington

    Bloomington, Illinois, 61704, United States

  • Illinois CancerCare-Canton

    Canton, Illinois, 61520, United States

  • Illinois CancerCare-Carthage

    Carthage, Illinois, 62321, United States

  • Illinois CancerCare-Eureka

    Eureka, Illinois, 61530, United States

  • Illinois CancerCare-Galesburg

    Galesburg, Illinois, 61401, United States

  • Illinois CancerCare-Kewanee Clinic

    Kewanee, Illinois, 61443, United States

  • Illinois CancerCare-Macomb

    Macomb, Illinois, 61455, United States

  • Illinois CancerCare-Ottawa Clinic

    Ottawa, Illinois, 61350, United States

  • Illinois CancerCare-Pekin

    Pekin, Illinois, 61554, United States

  • Illinois CancerCare-Peoria

    Peoria, Illinois, 61615, United States

  • Illinois CancerCare-Peru

    Peru, Illinois, 61354, United States

  • Illinois CancerCare-Princeton

    Princeton, Illinois, 61356, United States

  • Indu and Raj Soin Medical Center

    Beavercreek, Ohio, 45431, United States

  • Inova Alexandria Hospital

    Alexandria, Virginia, 22304, United States

  • Inova Fair Oaks Hospital

    Fairfax, Virginia, 22033, United States

  • Inova Schar Cancer Institute

    Fairfax, Virginia, 22031, United States

  • Intermountain Medical Center

    Murray, Utah, 84107, United States

  • Iowa Lutheran Hospital

    Des Moines, Iowa, 50316, United States

  • Iowa Methodist Medical Center

    Des Moines, Iowa, 50309, United States

  • Jefferson Hospital

    Jefferson Hills, Pennsylvania, 15025, United States

  • Jewish Hospital

    Louisville, Kentucky, 40202, United States

  • John H Stroger Jr Hospital of Cook County

    Chicago, Illinois, 60612, United States

  • Kaiser Permanente Cancer Treatment Center

    South San Francisco, California, 94080, United States

  • Kaiser Permanente Downtown Commons

    Sacramento, California, 95814, United States

  • Kaiser Permanente Dublin

    Dublin, California, 94568, United States

  • Kaiser Permanente Fresno Orchard Plaza

    Fresno, California, 93720, United States

  • Kaiser Permanente Los Angeles Medical Center

    Los Angeles, California, 90027, United States

  • Kaiser Permanente Medical Center - Santa Clara

    Santa Clara, California, 95051, United States

  • Kaiser Permanente Medical Center-Vacaville

    Vacaville, California, 95688, United States

  • Kaiser Permanente Oakland-Broadway

    Oakland, California, 94611, United States

  • Kaiser Permanente San Leandro

    San Leandro, California, 94577, United States

  • Kaiser Permanente- Marshall Medical Offices

    Redwood City, California, 94063, United States

  • Kaiser Permanente-Anaheim

    Anaheim, California, 92806, United States

  • Kaiser Permanente-Bellflower

    Bellflower, California, 90706, United States

  • Kaiser Permanente-Deer Valley Medical Center

    Antioch, California, 94531, United States

  • Kaiser Permanente-Franklin

    Denver, Colorado, 80205, United States

  • Kaiser Permanente-Fremont

    Fremont, California, 94538, United States

  • Kaiser Permanente-Fresno

    Fresno, California, 93720, United States

  • Kaiser Permanente-Irvine

    Irvine, California, 92618, United States

  • Kaiser Permanente-Lone Tree

    Lone Tree, Colorado, 80124, United States

  • Kaiser Permanente-Modesto

    Modesto, California, 95356, United States

  • Kaiser Permanente-Oakland

    Oakland, California, 94611, United States

  • Kaiser Permanente-Ontario

    Ontario, California, 91761, United States

  • Kaiser Permanente-Rancho Cordova Cancer Center

    Rancho Cordova, California, 95670, United States

  • Kaiser Permanente-Richmond

    Richmond, California, 94801, United States

  • Kaiser Permanente-Rock Creek

    Lafayette, Colorado, 80026, United States

  • Kaiser Permanente-Roseville

    Roseville, California, 95661, United States

  • Kaiser Permanente-San Francisco

    San Francisco, California, 94115, United States

  • Kaiser Permanente-Santa Rosa

    Santa Rosa, California, 95403, United States

  • Kaiser Permanente-Santa Teresa-San Jose

    San Jose, California, 95119, United States

  • Kaiser Permanente-South Sacramento

    Sacramento, California, 95823, United States

  • Kaiser Permanente-South San Francisco

    South San Francisco, California, 94080, United States

  • Kaiser Permanente-Stockton

    Stockton, California, 95210, United States

  • Kaiser Permanente-Vallejo

    Vallejo, California, 94589, United States

  • Kaiser Permanente-Walnut Creek

    Walnut Creek, California, 94596, United States

  • Kaiser San Rafael-Gallinas

    San Rafael, California, 94903, United States

  • Kantonsspital Aarau

    Aarau, 5001, Switzerland

  • Kettering Medical Center

    Kettering, Ohio, 45429, United States

  • LDS Hospital

    Salt Lake City, Utah, 84143, United States

  • Lafayette Family Cancer Center-EMMC

    Brewer, Maine, 04412, United States

  • Langlade Hospital and Cancer Center

    Antigo, Wisconsin, 54409, United States

  • Lankenau Medical Center

    Wynnewood, Pennsylvania, 19096, United States

  • Logan Regional Hospital

    Logan, Utah, 84321, United States

  • Louisiana State University Health Science Center

    New Orleans, Louisiana, 70112, United States

  • Loyola University Medical Center

    Maywood, Illinois, 60153, United States

  • Lutheran Hospital - Cancer Centers of Colorado

    Golden, Colorado, 80401, United States

  • MU Health Care Goldschmidt Cancer Center

    Jefferson City, Missouri, 65109, United States

  • MaineHealth Cancer Care Center of York County

    Sanford, Maine, 04073, United States

  • MaineHealth Cancer Care and IV Therapy - Sanford

    Sanford, Maine, 04073, United States

  • MaineHealth Cancer Care and IV Therapy - South Portland

    South Portland, Maine, 04106, United States

  • MaineHealth Coastal Cancer Treatment Center

    Bath, Maine, 04530, United States

  • MaineHealth Maine Medical Center - Biddeford

    Biddeford, Maine, 04005, United States

  • MaineHealth Maine Medical Center - Portland

    Portland, Maine, 04102, United States

  • MaineHealth Maine Medical Center- Scarborough

    Scarborough, Maine, 04074, United States

  • Marshfield Medical Center - Minocqua

    Minocqua, Wisconsin, 54548, United States

  • Marshfield Medical Center - Weston

    Weston, Wisconsin, 54476, United States

  • Marshfield Medical Center-EC Cancer Center

    Eau Claire, Wisconsin, 54701, United States

  • Marshfield Medical Center-Marshfield

    Marshfield, Wisconsin, 54449, United States

  • Marshfield Medical Center-Rice Lake

    Rice Lake, Wisconsin, 54868, United States

  • Marshfield Medical Center-River Region at Stevens Point

    Stevens Point, Wisconsin, 54482, United States

  • Maryland Proton Treatment Center

    Baltimore, Maryland, 21201, United States

  • McKay-Dee Hospital Center

    Ogden, Utah, 84403, United States

  • MedStar Georgetown University Hospital

    Washington D.C., District of Columbia, 20007, United States

  • Medical College of Wisconsin

    Milwaukee, Wisconsin, 53226, United States

  • Medical University of South Carolina

    Charleston, South Carolina, 29425, United States

  • Memorial Medical Center

    Modesto, California, 95355, United States

  • Mercy Cancer Center - Carmichael

    Carmichael, California, 95608, United States

  • Mercy Cancer Center - Elk Grove

    Elk Grove, California, 95758, United States

  • Mercy Cancer Center - Rocklin

    Rocklin, California, 95765, United States

  • Mercy Cancer Center - Sacramento

    Sacramento, California, 95816, United States

  • Mercy Cancer Center-West Lakes

    Clive, Iowa, 50325, United States

  • Mercy Clinic-Rolla-Cancer and Hematology

    Rolla, Missouri, 65401, United States

  • Mercy Hospital Saint Louis

    St Louis, Missouri, 63141, United States

  • Mercy Hospital Springfield

    Springfield, Missouri, 65804, United States

  • Mercy Medical Center - Des Moines

    Des Moines, Iowa, 50314, United States

  • Mercy Medical Center-West Lakes

    West Des Moines, Iowa, 50266, United States

  • Mercy San Juan Medical Center

    Carmichael, California, 95608, United States

  • Methodist Medical Center of Illinois

    Peoria, Illinois, 61636, United States

  • Methodist West Hospital

    West Des Moines, Iowa, 50266-7700, United States

  • Methodist Willowbrook Hospital

    Houston, Texas, 77070, United States

  • MetroHealth Medical Center

    Cleveland, Ohio, 44109, United States

  • Miami Valley Cancer Care and Infusion

    Greenville, Ohio, 45331, United States

  • Miami Valley Hospital

    Dayton, Ohio, 45409, United States

  • Miami Valley Hospital North

    Dayton, Ohio, 45415, United States

  • Miami Valley Hospital South

    Centerville, Ohio, 45459, United States

  • Michael E DeBakey VA Medical Center

    Houston, Texas, 77030, United States

  • Michigan Healthcare Professionals Clarkston

    Clarkston, Michigan, 48346, United States

  • Michigan Healthcare Professionals Farmington

    Farmington Hills, Michigan, 48334, United States

  • Michigan Healthcare Professionals Macomb

    Macomb, Michigan, 48044, United States

  • Michigan Healthcare Professionals Madison Heights

    Madison Heights, Michigan, 48071, United States

  • Michigan Healthcare Professionals Pontiac

    Pontiac, Michigan, 48341, United States

  • Michigan Healthcare Professionals Troy

    Troy, Michigan, 48098, United States

  • Missouri Baptist Medical Center

    St Louis, Missouri, 63131, United States

  • Missouri Baptist Sullivan Hospital

    Sullivan, Missouri, 63080, United States

  • Mobile Infirmary Medical Center

    Mobile, Alabama, 36607, United States

  • Moffitt Cancer Center

    Tampa, Florida, 33612, United States

  • Moffitt Cancer Center - McKinley Campus

    Tampa, Florida, 33612, United States

  • Moffitt Cancer Center at Wesley Chapel

    Wesley Chapel, Florida, 33544, United States

  • Moffitt Cancer Center-International Plaza

    Tampa, Florida, 33607, United States

  • Monticello Cancer Center

    Monticello, Minnesota, 55362, United States

  • NEA Baptist Memorial Hospital and Fowler Family Cancer Center - Jonesboro

    Jonesboro, Arkansas, 72401, United States

  • Nebraska Medicine-Bellevue

    Bellevue, Nebraska, 68123, United States

  • Nebraska Medicine-Village Pointe

    Omaha, Nebraska, 68118, United States

  • North Coast Cancer Care

    Sandusky, Ohio, 44870, United States

  • Novant Cancer Institute Radiation Oncology - Supply

    Supply, North Carolina, 28462, United States

  • Novant Health Cancer Institute Radiation Oncology - Wilmington

    Wilmington, North Carolina, 28401, United States

  • Novant Health New Hanover Regional Medical Center

    Wilmington, North Carolina, 28401, United States

  • Ohio State University Comprehensive Cancer Center

    Columbus, Ohio, 43210, United States

  • Ottawa Hospital and Cancer Center-General Campus

    Ottawa, Ontario, K1H 8L6, Canada

  • Pacific Central Coast Health Center-San Luis Obispo

    San Luis Obispo, California, 93401, United States

  • Palo Alto Medical Foundation Health Care

    Palo Alto, California, 94301, United States

  • Palo Alto Medical Foundation-Camino Division

    Mountain View, California, 94040, United States

  • Palo Alto Medical Foundation-Fremont

    Fremont, California, 94538, United States

  • Palo Alto Medical Foundation-Sunnyvale

    Sunnyvale, California, 94086, United States

  • Pamela Youde Nethersole Eastern Hospital

    Chai Wan, Hong Kong

  • Paoli Memorial Hospital

    Paoli, Pennsylvania, 19301, United States

  • Parkland Health Center - Farmington

    Farmington, Missouri, 63640, United States

  • Penn State Milton S Hershey Medical Center

    Hershey, Pennsylvania, 17033-0850, United States

  • Phelps Health Delbert Day Cancer Institute

    Rolla, Missouri, 65401, United States

  • Premier Blood and Cancer Center

    Dayton, Ohio, 45409, United States

  • ProHealth D N Greenwald Center

    Mukwonago, Wisconsin, 53149, United States

  • ProHealth Oconomowoc Memorial Hospital

    Oconomowoc, Wisconsin, 53066, United States

  • ProMedica Flower Hospital

    Sylvania, Ohio, 43560, United States

  • ProMedica Toledo Hospital/Russell J Ebeid Children's Hospital

    Toledo, Ohio, 43606, United States

  • Riddle Memorial Hospital

    Media, Pennsylvania, 19063, United States

  • Riverton Hospital

    Riverton, Utah, 84065, United States

  • Rohnert Park Cancer Center

    Rohnert Park, California, 94928, United States

  • Roswell Park Cancer Institute

    Buffalo, New York, 14263, United States

  • Rush-Copley Medical Center

    Aurora, Illinois, 60504, United States

  • Saint Francis Cancer Center

    Colorado Springs, Colorado, 80923, United States

  • Saint Francis Medical Center

    Cape Girardeau, Missouri, 63703, United States

  • Saint George Regional Medical Center

    St. George, Utah, 84770, United States

  • Saint James Community Hospital and Cancer Treatment Center

    Butte, Montana, 59701, United States

  • Saint Joseph Hospital

    Lexington, Kentucky, 40504, United States

  • Saint Joseph Hospital - Cancer Centers of Colorado

    Denver, Colorado, 80218, United States

  • Saint Joseph Hospital East

    Lexington, Kentucky, 40509, United States

  • Saint Joseph Radiation Oncology Resource Center

    Lexington, Kentucky, 40504, United States

  • Saint Lukes Hospital

    Dublin, Co Dublin, 6, Ireland

  • Saint Vincent Hospital

    Erie, Pennsylvania, 16544, United States

  • Sainte Genevieve County Memorial Hospital

    Sainte Genevieve, Missouri, 63670, United States

  • Salina Regional Health Center

    Salina, Kansas, 67401, United States

  • Sandra L Maxwell Cancer Center

    Cedar City, Utah, 84720, United States

  • Sanford Bismarck Medical Center

    Bismarck, North Dakota, 58501, United States

  • Sanford Broadway Medical Center

    Fargo, North Dakota, 58122, United States

  • Sanford Cancer Center Oncology Clinic

    Sioux Falls, South Dakota, 57104, United States

  • Sanford Joe Lueken Cancer Center

    Bemidji, Minnesota, 56601, United States

  • Sanford Roger Maris Cancer Center

    Fargo, North Dakota, 58122, United States

  • Sanford USD Medical Center - Sioux Falls

    Sioux Falls, South Dakota, 57117-5134, United States

  • Saskatoon Cancer Centre

    Saskatoon, Saskatchewan, S7N 4H4, Canada

  • Self Regional Healthcare

    Greenwood, South Carolina, 29646, United States

  • South Sacramento Cancer Center

    Sacramento, California, 95823, United States

  • Southern Illinois University School of Medicine

    Springfield, Illinois, 62702, United States

  • Springfield Clinic

    Springfield, Illinois, 62702, United States

  • Springfield Memorial Hospital

    Springfield, Illinois, 62781, United States

  • Stanford Cancer Center South Bay

    San Jose, California, 95124, United States

  • Stanford Cancer Institute Palo Alto

    Palo Alto, California, 94304, United States

  • Stony Brook University Medical Center

    Stony Brook, New York, 11794, United States

  • Summa Health Medina Medical Center

    Medina, Ohio, 44256, United States

  • Summa Health System - Akron Campus

    Akron, Ohio, 44304, United States

  • Summa Health System - Barberton Campus

    Barberton, Ohio, 44203, United States

  • Sutter Auburn Faith Hospital

    Auburn, California, 95602, United States

  • Sutter Cancer Centers Radiation Oncology Services-Auburn

    Auburn, California, 95603, United States

  • Sutter Cancer Centers Radiation Oncology Services-Roseville

    Roseville, California, 95661, United States

  • Sutter Medical Center Sacramento

    Sacramento, California, 95816, United States

  • Sutter Pacific Medical Foundation

    Santa Rosa, California, 95403, United States

  • Sutter Roseville Medical Center

    Roseville, California, 95661, United States

  • Temple University Hospital

    Philadelphia, Pennsylvania, 19140, United States

  • The Angeles Clinic and Research Institute - West Los Angeles Office

    Los Angeles, California, 90025, United States

  • The Carle Foundation Hospital

    Urbana, Illinois, 61801, United States

  • The James Graham Brown Cancer Center at University of Louisville

    Louisville, Kentucky, 40202, United States

  • The Permanente Medical Group-Roseville Radiation Oncology

    Roseville, California, 95678, United States

  • The Research Institute of the McGill University Health Centre (MUHC)

    Montreal, Quebec, H3H 2R9, Canada

  • The University of Kansas Cancer Center - Olathe

    Olathe, Kansas, 66061, United States

  • Tower Cancer Research Foundation

    Beverly Hills, California, 90211, United States

  • Trinity Health IHA Medical Group Hematology Oncology - Brighton

    Brighton, Michigan, 48114, United States

  • Trinity Health IHA Medical Group Hematology Oncology - Canton

    Canton, Michigan, 48188, United States

  • Trinity Health IHA Medical Group Hematology Oncology - Chelsea Hospital

    Chelsea, Michigan, 48118, United States

  • Trinity Health IHA Medical Group Hematology Oncology Ann Arbor Campus

    Ypsilanti, Michigan, 48197, United States

  • Trinity Health Medical Center - Brighton

    Brighton, Michigan, 48114, United States

  • Trinity Health Medical Center - Canton

    Canton, Michigan, 48188, United States

  • Trinity Health Saint Joseph Mercy Hospital Ann Arbor

    Ann Arbor, Michigan, 48106, United States

  • Trinity Health Saint Joseph Mercy Oakland Hospital

    Pontiac, Michigan, 48341, United States

  • Trinity Health Saint Mary Mercy Livonia Hospital

    Livonia, Michigan, 48154, United States

  • UC Irvine Health Cancer Center-Newport

    Costa Mesa, California, 92627, United States

  • UC Irvine Health/Chao Family Comprehensive Cancer Center

    Orange, California, 92868, United States

  • UC San Diego Health System - Encinitas

    Encinitas, California, 92024, United States

  • UC San Diego Medical Center - Hillcrest

    San Diego, California, 92103, United States

  • UC San Diego Moores Cancer Center

    La Jolla, California, 92093, United States

  • UCI Health - Chao Family Comprehensive Cancer Center and Ambulatory Care

    Irvine, California, 92612, United States

  • UCSF Medical Center-Mission Bay

    San Francisco, California, 94158, United States

  • UCSF Medical Center-Mount Zion

    San Francisco, California, 94115, United States

  • UH Seidman Cancer Center at Lake Health Mentor Campus

    Mentor, Ohio, 44060, United States

  • UH Seidman Cancer Center at UH Avon Health Center

    Avon, Ohio, 44011, United States

  • UI Health Care Mission Cancer and Blood - Ankeny Clinic

    Ankeny, Iowa, 50023, United States

  • UI Health Care Mission Cancer and Blood - Des Moines Clinic

    Des Moines, Iowa, 50309, United States

  • UI Health Care Mission Cancer and Blood - Laurel Clinic

    Des Moines, Iowa, 50314, United States

  • UI Health Care Mission Cancer and Blood - Waukee Clinic

    Waukee, Iowa, 50263, United States

  • UI Health Care Mission Cancer and Blood - West Des Moines Clinic

    Clive, Iowa, 50325, United States

  • UM Baltimore Washington Medical Center/Tate Cancer Center

    Glen Burnie, Maryland, 21061, United States

  • UM Sylvester Comprehensive Cancer Center at Aventura

    Aventura, Florida, 33180, United States

  • UM Sylvester Comprehensive Cancer Center at Coral Gables

    Coral Gables, Florida, 33146, United States

  • UM Sylvester Comprehensive Cancer Center at Deerfield Beach

    Deerfield Beach, Florida, 33442, United States

  • UM Sylvester Comprehensive Cancer Center at Doral

    Doral, Florida, 33166, United States

  • UM Sylvester Comprehensive Cancer Center at Kendall

    Miami, Florida, 33176, United States

  • UM Sylvester Comprehensive Cancer Center at Plantation

    Plantation, Florida, 33324, United States

  • UM Upper Chesapeake Medical Center

    Bel Air, Maryland, 21014, United States

  • UW Cancer Center at ProHealth Care

    Waukesha, Wisconsin, 53188, United States

  • UW Health Carbone Cancer Center Rockford

    Rockford, Illinois, 61114, United States

  • University College Hospital Galway

    Galway, Co Galway, Ireland

  • University Health Network-Princess Margaret Hospital

    Toronto, Ontario, M5G 2M9, Canada

  • University Hospitals Portage Medical Center

    Ravenna, Ohio, 44266, United States

  • University Medical Center New Orleans

    New Orleans, Louisiana, 70112, United States

  • University of Arkansas for Medical Sciences

    Little Rock, Arkansas, 72205, United States

  • University of California Davis Comprehensive Cancer Center

    Sacramento, California, 95817, United States

  • University of Kansas Cancer Center

    Kansas City, Kansas, 66160, United States

  • University of Kansas Cancer Center - Lee's Summit

    Lee's Summit, Missouri, 64064, United States

  • University of Kansas Cancer Center - North

    Kansas City, Missouri, 64154, United States

  • University of Kansas Cancer Center at North Kansas City Hospital

    North Kansas City, Missouri, 64116, United States

  • University of Kansas Cancer Center-Overland Park

    Overland Park, Kansas, 66210, United States

  • University of Kansas Health System Saint Francis Campus

    Topeka, Kansas, 66606, United States

  • University of Kansas Hospital-Westwood Cancer Center

    Westwood, Kansas, 66205, United States

  • University of Kentucky/Markey Cancer Center

    Lexington, Kentucky, 40536, United States

  • University of Maryland/Greenebaum Cancer Center

    Baltimore, Maryland, 21201, United States

  • University of Miami Miller School of Medicine-Sylvester Cancer Center

    Miami, Florida, 33136, United States

  • University of Michigan - Brighton Center for Specialty Care

    Brighton, Michigan, 48116, United States

  • University of Michigan Rogel Cancer Center

    Ann Arbor, Michigan, 48109, United States

  • University of Mississippi Medical Center

    Jackson, Mississippi, 39216, United States

  • University of Nebraska Medical Center

    Omaha, Nebraska, 68198, United States

  • University of New Mexico Cancer Center

    Albuquerque, New Mexico, 87106, United States

  • University of Oklahoma Health Sciences Center

    Oklahoma City, Oklahoma, 73104, United States

  • University of Rochester

    Rochester, New York, 14642, United States

  • University of Washington Medical Center - Montlake

    Seattle, Washington, 98195, United States

  • University of Wisconsin Carbone Cancer Center - Eastpark Medical Center

    Madison, Wisconsin, 53718, United States

  • University of Wisconsin Carbone Cancer Center - Johnson Creek

    Johnson Creek, Wisconsin, 53038, United States

  • University of Wisconsin Carbone Cancer Center - University Hospital

    Madison, Wisconsin, 53792, United States

  • UofL Health Medical Center Northeast

    Louisville, Kentucky, 40245, United States

  • Upper Valley Medical Center

    Troy, Ohio, 45373, United States

  • Utah Cancer Specialists-Salt Lake City

    Salt Lake City, Utah, 84106, United States

  • Utah Valley Regional Medical Center

    Provo, Utah, 84604, United States

  • VA Palo Alto Health Care System

    Palo Alto, California, 94304, United States

  • Wake Forest Baptist Health - Wilkes Medical Center

    Wilkesboro, North Carolina, 28659, United States

  • Wake Forest University Health Sciences

    Winston-Salem, North Carolina, 27157, United States

  • West Virginia University Charleston Division

    Charleston, West Virginia, 25304, United States

  • Wexford Health and Wellness Pavilion

    Wexford, Pennsylvania, 15090, United States

  • William S Middleton VA Medical Center

    Madison, Wisconsin, 53705, United States

  • Wilmot Cancer Institute at Webster

    Webster, New York, 14580, United States

  • Woodland Memorial Hospital

    Woodland, California, 95695, United States

  • Zablocki Veterans Administration Medical Center

    Milwaukee, Wisconsin, 53295, United States

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