Lung cancer trial tests two new combo therapies against tough disease

NCT ID NCT00887159

Disease control Sponsor: National Cancer Institute (NCI) Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This phase II trial studied 168 people with extensive-stage small cell lung cancer. Researchers added either vismodegib or cixutumumab to standard chemotherapy (cisplatin and etoposide) to see if these combinations worked better than chemo alone. The goal was to slow cancer growth and improve survival.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance: cisplatin, etoposide, vismodegib, cixutumumab
What this could lead to: If successful, this could point toward a more effective combination therapy for extensive-stage small cell lung cancer, potentially improving how long patients live without their cancer worsening.
What could go wrong: This is a phase II trial, so results are still early and may not lead to a new standard treatment. The added drugs may also cause more side effects without clear benefit.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 2

Tests whether the treatment actually works, and watches for side effects, in a larger group.

Participants

168 people

The number who actually took part.

Started

Jul 2009

Finished

Nov 2016

Lead sponsor

A government research agency

The lead sponsor is the US National Institutes of Health.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Histologically or cytologically confirmed small cell lung cancer (SCLC) * Extensive stage SCLC * Extensive stage disease: the extensive disease classification for this protocol includes all patients with disease sites not defined as limited stage; limited stage disease category includes patients with disease restricted to one hemithorax with regional lymph node metastases, including hilar, ipsilateral and contralateral mediastinal, and/or ipsilateral supraclavicular nodes; extensive disease patients are defined as those patients with extrathoracic metastatic disease, malignant pleural effusion, bilateral or contralateral supraclavicular adenopathy * Measurable disease based on Response Evaluation Criteria in Solid Tumors (RECIST); baseline measurements and evaluations of all sites of disease must be obtained =\< 4 weeks prior to randomization * Eastern Cooperative Oncology Group (ECOG) performance status 0 or 1 * Absolute neutrophil count (ANC) \>= 1,500/mm\^3 * Platelets \>= 100,000/mm\^3 * Total bilirubin =\< 1.5 x institutional upper limit of normal (ULN) * Aspartate aminotransferase (AST) (serum glutamic oxaloacetic transaminase)/alanine aminotransferase (ALT) (serum glutamate pyruvate transaminase) =\< 3 x institutional ULN (=\< 5 x ULN if liver function test \[LFT\] elevations are due to liver metastases) * Creatinine =\< 1.5 x institutional ULN OR creatinine clearance \>= 60 mL/min/1.73 m\^2 for patients with creatinine levels \> 1.5 x institutional ULN * Leukocytes \>= 3,000/mm\^3 * Hemoglobin \>= 9 g/dL * Fasting serum glucose \< 120 mg/dL or below institutional ULN =\< 7 days prior to protocol randomization * Patients with central nervous system (CNS) metastases will be eligible if they have completed a course of CNS radiotherapy and have stable neurologic function for a minimum of 28 days prior to study randomization; radiotherapy must have been completed a minimum of 28 days prior to randomization, and patients must have recovered from any adverse events related to the radiotherapy (except alopecia and grade 1 neuropathy) and have stable neurologic function for a minimum of 28 days prior to study randomization * NOTE: the use of prophylactic cranial irradiation (recommended dose 25 Gy) in those who completed protocol chemotherapy and have a response (in the absence of progressive disease \[PD\]) is allowed; for patients on Arms B and C, GDC-0449 and IMC-A12 will be held while patient is receiving prophylactic cranial irradiation (PCI); these agents can be reinstituted after PCI is completed * Women of child-bearing potential (WCBP) and men must agree to use adequate contraception (hormonal or barrier method of birth control; abstinence) prior to study entry and for the duration of study participation * WCBP must agree to use two reliable forms of contraception simultaneously or to practice complete abstinence from heterosexual intercourse; the two methods of reliable contraception must include one highly effective method (i.e., intrauterine device \[IUD\], hormonal \[birth control pills, injections, or implants\], tubal ligation, partner?s vasectomy) and one additional effective (barrier) method (i.e., latex condom, diaphragm, cervical cap); WCBP must be referred to a qualified provider of contraceptive methods if needed * NOTE: the WCBP randomized to Arm B must agree to use two reliable forms of contraception simultaneously or to practice complete abstinence from heterosexual intercourse during the following two additional time periods related to this study: 1) while participating in the study; and 2) for at least 12 months after discontinuation from the study * Before starting the study drugs, all WCBP must have a negative pregnancy test (sensitivity of at least 50 mIU/mL); the pregnancy test must be performed within 10-14 days prior to randomization * NOTE: the WCBP randomized to Arm B must have a second pregnancy test performed within the 24 hours prior to the start of the GDC-0449; the subject may not receive GDC-0449 until the investigator has verified that the results of these pregnancy tests are negative * The WCBP randomized to Arm B will be warned that sharing the study drug is prohibited and will be counseled about pregnancy precautions and potential risks or fetal exposure; she must also agree to abstain from donating blood during study participation and at least 12 months after discontinuation from the study drug * NOTE: male subjects randomized to Arm B must agree to use a latex condom during sexual contact with WCBP while participating in the study and for at least 12 months following discontinuation from the study even if he has undergone a successful vasectomy * Male subjects randomized to Arm B will be warned that sharing study drug is prohibited and will be counseled about pregnancy precautions and potential risks of fetal exposure; male subjects must agree to abstain from donating blood, semen, or sperm during study participation and for at least 3 months after discontinuation from the study drug Exclusion Criteria: * Pregnant or breastfeeding; all WCBP must have a blood test within 10-14 days prior to randomization to rule out pregnancy * Prior chemotherapy or biologic therapy for SCLC; patients with prior radiation may be eligible or after palliative radiotherapy for other sites of disease; patients receiving prior radiation cannot start therapy within 14 days after completion of radiation, and must have recovered from adverse events attributed to radiation; no previous irradiation to the only site of measurable or evaluable disease, unless that site had subsequent evidence of progression * Receiving any other investigational agents * History of allergic reactions attributed to compounds of similar chemical or biological composition to GDC-0449 and IMC-A12 or other agents used in the study * Uncontrolled intercurrent illness including, but not limited to, ongoing or active infection, symptomatic congestive heart failure, unstable angina pectoris, uncontrolled cardiac arrhythmia, or psychiatric illness/social situations that would limit compliance with study requirements * Human immunodeficiency virus (HIV)-positive patients on combination antiretroviral therapy * Poorly controlled diabetes mellitus; patients with a history of diabetes mellitus are allowed to participate, provided that their blood glucose is within normal range (fasting \< 120 mg/dL or below institutional upper limit of normal) and that they are on a stable dietary or therapeutic regimen for this condition * Patients with major surgery, hormonal therapy (other than replacement), within 4 weeks prior to entering the study or those who have not recovered from adverse events * Prior treatment with other agents targeting the IGFR or the Hedgehog signaling pathway

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Conditions

The condition(s) this trial relates to.

small cell lung carcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Extensive stage small cell lung carcinoma Recurrent small cell lung carcinoma

Contacts and locations

Locations

Abbott-Northwestern Hospital

Minneapolis, Minnesota, 55407, United States
Abington Memorial Hospital

Abington, Pennsylvania, 19001, United States
Adams Cancer Center

Gettysburg, Pennsylvania, 17325, United States
Adena Regional Medical Center

Chillicothe, Ohio, 45601, United States
Alegent Health Bergan Mercy Medical Center

Omaha, Nebraska, 68124, United States
Alegent Health Immanuel Medical Center

Omaha, Nebraska, 68122, United States
Allegiance Health

Jackson, Michigan, 49201, United States
Ascension Saint Mary's Hospital

Rhinelander, Wisconsin, 54501, United States
Ascension Saint Michael's Hospital

Stevens Point, Wisconsin, 54481, United States
Associates In Womens Health

Wichita, Kansas, 67208, United States
Atlanta VA Medical Center

Decatur, Georgia, 30033, United States
Aultman Health Foundation

Canton, Ohio, 44710, United States
Aurora Saint Luke's Medical Center

Milwaukee, Wisconsin, 53215, United States
Avera Cancer Institute

Sioux Falls, South Dakota, 57105, United States
Avera McKennan Hospital and University Health Center

Sioux Falls, South Dakota, 57105, United States
Beaumont Hospital-Dearborn

Dearborn, Michigan, 48124, United States
Bixby Medical Center

Adrian, Michigan, 49221, United States
Boca Raton Regional Hospital

Boca Raton, Florida, 33486, United States
Borgess Medical Center

Kalamazoo, Michigan, 49001, United States
Boulder Community Hospital

Boulder, Colorado, 80301, United States
Bromenn Regional Medical Center

Normal, Illinois, 61761, United States
Bronson Methodist Hospital

Kalamazoo, Michigan, 49007, United States
Bryn Mawr Hospital

Bryn Mawr, Pennsylvania, 19010, United States
Butler Memorial Hospital

Butler, Pennsylvania, 16001, United States
Cancer Center of Kansas - Chanute

Chanute, Kansas, 66720, United States
Cancer Center of Kansas - Dodge City

Dodge City, Kansas, 67801, United States
Cancer Center of Kansas - El Dorado

El Dorado, Kansas, 67042, United States
Cancer Center of Kansas - Fort Scott

Fort Scott, Kansas, 66701, United States
Cancer Center of Kansas - Newton

Newton, Kansas, 67114, United States
Cancer Center of Kansas - Parsons

Parsons, Kansas, 67357, United States
Cancer Center of Kansas - Pratt

Pratt, Kansas, 67124, United States
Cancer Center of Kansas - Salina

Salina, Kansas, 67401, United States
Cancer Center of Kansas - Wellington

Wellington, Kansas, 67152, United States
Cancer Center of Kansas - Wichita

Wichita, Kansas, 67214, United States
Cancer Center of Kansas - Winfield

Winfield, Kansas, 67156, United States
Cancer Center of Kansas-Independence

Independence, Kansas, 67301, United States
Cancer Center of Kansas-Kingman

Kingman, Kansas, 67068, United States
Cancer Center of Kansas-Liberal

Liberal, Kansas, 67905, United States
Cancer Center of Kansas-Wichita Medical Arts Tower

Wichita, Kansas, 67208, United States
Case Western Reserve University

Cleveland, Ohio, 44106, United States
Cherry Tree Cancer Center

Hanover, Pennsylvania, 17331, United States
Colorado Cancer Research Program NCORP

Denver, Colorado, 80222, United States
Columbia Saint Mary's Water Tower Medical Commons

Milwaukee, Wisconsin, 53211, United States
Columbus NCI Community Oncology Research Program

Columbus, Ohio, 43215, United States
Community Cancer Center Foundation

Normal, Illinois, 61761, United States
Constantinou, Costas L MD (UIA Investigator)

Bettendorf, Iowa, 52722, United States
Creighton University Medical Center

Omaha, Nebraska, 68131, United States
Dallas VA Medical Center

Dallas, Texas, 75216, United States
Dean Hematology and Oncology Clinic

Madison, Wisconsin, 53717, United States
Decatur Memorial Hospital

Decatur, Illinois, 62526, United States
Dickstein Cancer Treatment Center

White Plains, New York, 10601, United States
Doctors Carrol, Sheth, Raghavan

Louisville, Kentucky, 40215, United States
Doctors Hospital

Columbus, Ohio, 43228, United States
Einstein Medical Center Philadelphia

Philadelphia, Pennsylvania, 19141, United States
Elmhurst Memorial Hospital

Elmhurst, Illinois, 60126, United States
Emory University Hospital/Winship Cancer Institute

Atlanta, Georgia, 30322, United States
Ephrata Cancer Center

Ephrata, Pennsylvania, 17522, United States
Essentia Health Cancer Center

Duluth, Minnesota, 55805, United States
Essentia Health Saint Mary's Medical Center

Duluth, Minnesota, 55805, United States
Eureka Hospital

Eureka, Illinois, 61530, United States
Fairfield Medical Center

Lancaster, Ohio, 43130, United States
Fairview Ridges Hospital

Burnsville, Minnesota, 55337, United States
Fairview-Southdale Hospital

Edina, Minnesota, 55435, United States
Fisher-Titus Medical Center

Norwalk, Ohio, 44857, United States
Flower Hospital

Sylvania, Ohio, 43560, United States
Frederick Memorial Hospital

Frederick, Maryland, 21701, United States
Fredericksburg Oncology Inc

Fredericksburg, Virginia, 22401, United States
Fulton County Health Center

Wauseon, Ohio, 43567, United States
Galesburg Cottage Hospital

Galesburg, Illinois, 61401, United States
Garneau, Stewart C MD (UIA Investigator)

Moline, Illinois, 61265, United States
Geisinger Medical Center

Danville, Pennsylvania, 17822, United States
Geisinger Medical Center-Cancer Center Hazleton

Hazleton, Pennsylvania, 18201, United States
Geisinger Medical Group

State College, Pennsylvania, 16801, United States
Geisinger Wyoming Valley/Henry Cancer Center

Wilkes-Barre, Pennsylvania, 18711, United States
Genesis Healthcare System Cancer Care Center

Zanesville, Ohio, 43701, United States
Genesys Regional Medical Center-West Flint Campus

Flint, Michigan, 48532, United States
Grady Memorial Hospital

Delaware, Ohio, 43015, United States
Graham Hospital Association

Canton, Illinois, 61520, United States
Grant Medical Center

Columbus, Ohio, 43215, United States
Greater Baltimore Medical Center

Baltimore, Maryland, 21204, United States
Gundersen Lutheran Medical Center

La Crosse, Wisconsin, 54601, United States
Guthrie Medical Group PC-Robert Packer Hospital

Sayre, Pennsylvania, 18840, United States
Hackensack University Medical Center

Hackensack, New Jersey, 07601, United States
Heartland Cancer Research NCORP

Decatur, Illinois, 62526, United States
Hematology Oncology Associates of Illinois - Skokie

Skokie, Illinois, 60076, United States
Hematology Oncology Associates of Illinois-Highland Park

Highland Park, Illinois, 60035, United States
Hematology Oncology Center Incorporated

Elyria, Ohio, 44035, United States
Hematology and Oncology Associates

Chicago, Illinois, 60611, United States
Hematology and Oncology Associates of North East Pennsylvania

Scranton, Pennsylvania, 18508, United States
Hennepin County Medical Center

Minneapolis, Minnesota, 55415, United States
Hickman Cancer Center

Adrian, Michigan, 49221, United States
Hinsdale Hematology Oncology Associates Incorporated

Hinsdale, Illinois, 60521, United States
Holy Family Medical Center

Monmouth, Illinois, 61462, United States
Hunterdon Medical Center

Flemington, New Jersey, 08822, United States
Hurley Medical Center

Flint, Michigan, 48503, United States
Hutchinson Area Health Care

Hutchinson, Minnesota, 55350, United States
Illinois Cancer Specialists-Niles

Niles, Illinois, 60714, United States
Illinois CancerCare-Bloomington

Bloomington, Illinois, 61704, United States
Illinois CancerCare-Canton

Canton, Illinois, 61520, United States
Illinois CancerCare-Carthage

Carthage, Illinois, 62321, United States
Illinois CancerCare-Community Cancer Center

Normal, Illinois, 61761, United States
Illinois CancerCare-Eureka

Eureka, Illinois, 61530, United States
Illinois CancerCare-Galesburg

Galesburg, Illinois, 61401, United States
Illinois CancerCare-Havana

Havana, Illinois, 62644, United States
Illinois CancerCare-Kewanee Clinic

Kewanee, Illinois, 61443, United States
Illinois CancerCare-Macomb

Macomb, Illinois, 61455, United States
Illinois CancerCare-Monmouth

Monmouth, Illinois, 61462, United States
Illinois CancerCare-Ottawa Clinic

Ottawa, Illinois, 61350, United States
Illinois CancerCare-Pekin

Pekin, Illinois, 61554, United States
Illinois CancerCare-Peoria

Peoria, Illinois, 61615, United States
Illinois CancerCare-Peru

Peru, Illinois, 61354, United States
Illinois CancerCare-Princeton

Princeton, Illinois, 61356, United States
Illinois CancerCare-Spring Valley

Spring Valley, Illinois, 61362, United States
Illinois Valley Hospital

Peru, Illinois, 61354, United States
Ingalls Memorial Hospital

Harvey, Illinois, 60426, United States
Iowa Lutheran Hospital

Des Moines, Iowa, 50316, United States
Iowa Methodist Medical Center

Des Moines, Iowa, 50309, United States
Iowa-Wide Oncology Research Coalition NCORP

Des Moines, Iowa, 50309, United States
John H Stroger Jr Hospital of Cook County

Chicago, Illinois, 60612, United States
Johns Hopkins University/Sidney Kimmel Cancer Center

Baltimore, Maryland, 21287, United States
Joliet Oncology-Hematology Associates Limited

Joliet, Illinois, 60435, United States
Knox Community Hospital

Mount Vernon, Ohio, 43050, United States
Lake Huron Medical Center

Port Huron, Michigan, 48060, United States
Lake Region Healthcare Corporation-Cancer Care

Fergus Falls, Minnesota, 56537, United States
Lakeview Hospital

Stillwater, Minnesota, 55082, United States
Lancaster General Hospital

Lancaster, Pennsylvania, 17604, United States
Lankenau Medical Center

Wynnewood, Pennsylvania, 19096, United States
Laura and Isaac Perlmutter Cancer Center at NYU Langone

New York, New York, 10016, United States
Lawrence Memorial Hospital

Lawrence, Kansas, 66044, United States
Lehigh Valley Hospital-Cedar Crest

Allentown, Pennsylvania, 18103, United States
Lewis Cancer and Research Pavilion at Saint Joseph's/Candler

Savannah, Georgia, 31405, United States
Lewistown Hospital

Lewistown, Pennsylvania, 17044, United States
Licking Memorial Hospital

Newark, Ohio, 43055, United States
Lima Memorial Hospital

Lima, Ohio, 45804, United States
Longmont United Hospital

Longmont, Colorado, 80501, United States
Lovelace Medical Center-Saint Joseph Square

Albuquerque, New Mexico, 87102, United States
Marietta Memorial Hospital

Marietta, Ohio, 45750, United States
Marshfield Clinic

Marshfield, Wisconsin, 54449, United States
Marshfield Clinic - Weston Center

Weston, Wisconsin, 54476, United States
Marshfield Clinic - Wisconsin Rapids Center

Wisconsin Rapids, Wisconsin, 54494, United States
Marshfield Clinic Cancer Center at Sacred Heart

Eau Claire, Wisconsin, 54701, United States
Marshfield Clinic-Chippewa Center

Chippewa Falls, Wisconsin, 54729, United States
Marshfield Clinic-Minocqua Center

Minocqua, Wisconsin, 54548, United States
Marshfield Clinic-Rice Lake Center

Rice Lake, Wisconsin, 54868, United States
Mary Rutan Hospital

Bellefontaine, Ohio, 43311, United States
Mason District Hospital

Havana, Illinois, 62644, United States
Mayo Clinic in Arizona

Scottsdale, Arizona, 85259, United States
Mayo Clinic in Florida

Jacksonville, Florida, 32224-9980, United States
McFarland Clinic PC-William R Bliss Cancer Center

Ames, Iowa, 50010, United States
McKee Medical Center

Loveland, Colorado, 80539, United States
Mcdonough District Hospital

Macomb, Illinois, 61455, United States
Medical Center of Central Georgia

Macon, Georgia, 31201, United States
Medical Oncology and Hematology Associates-Des Moines

Des Moines, Iowa, 50309, United States
Medical Oncology and Hematology Associates-Laurel

Des Moines, Iowa, 50314, United States
Medical Oncology and Hematology Associates-West Des Moines

Clive, Iowa, 50325, United States
Medical X-Ray Center

Sioux Falls, South Dakota, 57105, United States
Memorial Hospital

Carthage, Illinois, 62321, United States
Memorial Medical Center

Springfield, Illinois, 62781, United States
Mercy Cancer Center-Elyria

Elyria, Ohio, 44035, United States
Mercy Capitol

Des Moines, Iowa, 50307, United States
Mercy Hospital

Coon Rapids, Minnesota, 55433, United States
Mercy Hospital

Scranton, Pennsylvania, 18501, United States
Mercy Hospital of Tiffin

Tiffin, Ohio, 44883, United States
Mercy Medical Center

Canton, Ohio, 44708, United States
Mercy Medical Center - Des Moines

Des Moines, Iowa, 50314, United States
Mercy Medical Center - North Iowa

Mason City, Iowa, 50401, United States
Mercy Medical Center-Sioux City

Sioux City, Iowa, 51104, United States
Mercy Memorial Hospital

Monroe, Michigan, 48162, United States
Mercy Saint Anne Hospital

Toledo, Ohio, 43623, United States
Methodist Medical Center of Illinois

Peoria, Illinois, 61603, United States
Metro Minnesota Community Oncology Research Consortium

Saint Louis Park, Minnesota, 55416, United States
Michigan Cancer Research Consortium NCORP

Ann Arbor, Michigan, 48106, United States
Miller-Dwan Hospital

Duluth, Minnesota, 55805, United States
Minnesota Oncology Hematology PA-Maplewood

Maplewood, Minnesota, 55109, United States
Minnesota Oncology Hematology PA-Woodbury

Woodbury, Minnesota, 55125, United States
Missouri Valley Cancer Consortium

Omaha, Nebraska, 68106, United States
Montefiore Medical Center - Moses Campus

The Bronx, New York, 10467, United States
Montefiore Medical Center-Weiler Hospital

The Bronx, New York, 10461, United States
Mount Carmel Health Center West

Columbus, Ohio, 43222, United States
Mount Nittany Medical Center

State College, Pennsylvania, 16803, United States
Natalie Warren Bryant Cancer Center at Saint Francis

Tulsa, Oklahoma, 74136, United States
Nebraska Cancer Research Center

Lincoln, Nebraska, 68510, United States
Nevada Cancer Research Foundation CCOP

Las Vegas, Nevada, 89106, United States
New York Oncology Hematology PC - Albany

Albany, New York, 12206, United States
New York Oncology Hematology PC - Amsterdam

Amsterdam, New York, 12010, United States
New York Oncology Hematology PC - Clifton Park

Clifton Park, New York, 12065, United States
New York Oncology Hematology PC - Rexford

Rexford, New York, 12148, United States
New York Oncology Hematology PC - Troy

Troy, New York, 12180, United States
New York Oncology Hematology PC -Albany Medical Center

Albany, New York, 12208, United States
New York Oncology Hematology PC-Hudson

Hudson, New York, 12534, United States
North Coast Cancer Care

Sandusky, Ohio, 44870, United States
North Coast Cancer Care-Clyde

Clyde, Ohio, 43410, United States
North Colorado Medical Center

Greeley, Colorado, 80631, United States
North Memorial Medical Health Center

Robbinsdale, Minnesota, 55422, United States
North Suburban Medical Center

Thornton, Colorado, 80229, United States
NorthShore Hematology Oncology-Libertyville

Libertyville, Illinois, 60048, United States
NorthShore University HealthSystem-Evanston Hospital

Evanston, Illinois, 60201, United States
Northwestern University

Chicago, Illinois, 60611, United States
OSF Saint Francis Radiation Oncology at Pekin Cancer Treatment Center

Pekin, Illinois, 61554, United States
Ottawa Regional Hospital and Healthcare Center

Ottawa, Illinois, 61350, United States
Ottumwa Regional Health Center

Ottumwa, Iowa, 52501, United States
Paoli Memorial Hospital

Paoli, Pennsylvania, 19301, United States
Park Nicollet Clinic - Saint Louis Park

Saint Louis Park, Minnesota, 55416, United States
Parkland Memorial Hospital

Dallas, Texas, 75235, United States
Pekin Hospital

Pekin, Illinois, 61554, United States
Penn State Milton S Hershey Medical Center

Hershey, Pennsylvania, 17033-0850, United States
Penrose-Saint Francis Healthcare

Colorado Springs, Colorado, 80907, United States
Perry Memorial Hospital

Princeton, Illinois, 61356, United States
Porter Adventist Hospital

Denver, Colorado, 80210, United States
Porubcin, Michael MD (UIA Investigator)

Moline, Illinois, 61265, United States
Presbyterian - Saint Lukes Medical Center - Health One

Denver, Colorado, 80218, United States
Presbyterian Kaseman Hospital

Albuquerque, New Mexico, 87110, United States
Presence Saint Joseph Hospital-Chicago

Chicago, Illinois, 60657, United States
Presence Saint Mary's Hospital

Kankakee, Illinois, 60901, United States
ProHealth Oconomowoc Memorial Hospital

Oconomowoc, Wisconsin, 53066, United States
ProHealth Waukesha Memorial Hospital

Waukesha, Wisconsin, 53188, United States
Proctor Hospital

Peoria, Illinois, 61614, United States
Reading Hospital

West Reading, Pennsylvania, 19611, United States
Regions Hospital

Saint Paul, Minnesota, 55101, United States
Rice Memorial Hospital

Willmar, Minnesota, 56201, United States
Ridgeview Medical Center

Waconia, Minnesota, 55387, United States
Riverside Methodist Hospital

Columbus, Ohio, 43214, United States
Rose Medical Center

Denver, Colorado, 80220, United States
Rush University Medical Center

Chicago, Illinois, 60612, United States
SCL Health Lutheran Medical Center

Wheat Ridge, Colorado, 80033, United States
SCL Health Saint Joseph Hospital

Denver, Colorado, 80218, United States
Saint Ann's Hospital

Westerville, Ohio, 43081, United States
Saint Anthony Hospital

Lakewood, Colorado, 80228, United States
Saint Charles Hospital

Oregon, Ohio, 43616, United States
Saint Francis Regional Medical Center

Shakopee, Minnesota, 55379, United States
Saint John Hospital and Medical Center

Detroit, Michigan, 48236, United States
Saint John Macomb-Oakland Hospital

Warren, Michigan, 48093, United States
Saint John's Hospital - Healtheast

Maplewood, Minnesota, 55109, United States
Saint Joseph Mercy Hospital

Ann Arbor, Michigan, 48106, United States
Saint Joseph Mercy Oakland

Pontiac, Michigan, 48341, United States
Saint Luke's Hospital

Maumee, Ohio, 43537, United States
Saint Luke's Regional Medical Center

Sioux City, Iowa, 51104, United States
Saint Margaret's Hospital

Spring Valley, Illinois, 61362, United States
Saint Mary Corwin Medical Center

Pueblo, Colorado, 81004, United States
Saint Mary Medical and Regional Cancer Center

Langhorne, Pennsylvania, 19047, United States
Saint Mary Mercy Hospital

Livonia, Michigan, 48154, United States
Saint Mary's Hospital and Regional Medical Center

Grand Junction, Colorado, 81501, United States
Saint Mary's of Michigan

Saginaw, Michigan, 48601, United States
Saint Rita's Medical Center

Lima, Ohio, 45801, United States
Saint Vincent Mercy Medical Center

Toledo, Ohio, 43608, United States
Sanford Broadway Medical Center

Fargo, North Dakota, 58122, United States
Sanford Cancer Center Oncology Clinic

Sioux Falls, South Dakota, 57104, United States
Sanford Clinic North-Bemidgi

Bemidji, Minnesota, 56601, United States
Sanford Clinic North-Fargo

Fargo, North Dakota, 58122, United States
Sanford USD Medical Center - Sioux Falls

Sioux Falls, South Dakota, 57117-5134, United States
Scranton Hematology Oncology

Scranton, Pennsylvania, 18510, United States
Sharis, Christine M MD (UIA Investigator)

Moline, Illinois, 61265, United States
Siouxland Regional Cancer Center

Sioux City, Iowa, 51101, United States
Sky Ridge Medical Center

Lone Tree, Colorado, 80124, United States
Smilow Cancer Hospital Care Center at Saint Francis

Hartford, Connecticut, 06105, United States
Smilow Cancer Hospital-Torrington Care Center

Torrington, Connecticut, 06790, United States
Southwest Medical Center

Liberal, Kansas, 67901, United States
Sparrow Hospital

Lansing, Michigan, 48912, United States
Sparta Cancer Treatment Center

Sparta, New Jersey, 07871, United States
Spector, David MD (UIA Investigator)

Moline, Illinois, 61265, United States
Springfield Regional Medical Center

Springfield, Ohio, 45505, United States
Stanford Cancer Institute Palo Alto

Palo Alto, California, 94304, United States
Stoffel, Thomas J MD (UIA Investigator)

Moline, Illinois, 61265, United States
Stony Brook University Medical Center

Stony Brook, New York, 11794, United States
Summa Akron City Hospital/Cooper Cancer Center

Akron, Ohio, 44304, United States
Summa Barberton Hospital

Barberton, Ohio, 44203, United States
Swedish American Hospital

Rockford, Illinois, 61104, United States
Swedish Medical Center

Englewood, Colorado, 80113, United States
SwedishAmerican Regional Cancer Center/ACT

Rockford, Illinois, 61114, United States
The Hospital of Central Connecticut

New Britain, Connecticut, 06050, United States
The Medical Center of Aurora

Aurora, Colorado, 80012, United States
The Memorial Hospital at Easton

Easton, Maryland, 21601, United States
The Toledo Hospital/Toledo Children's Hospital

Toledo, Ohio, 43606, United States
Thomas Jefferson University Hospital

Philadelphia, Pennsylvania, 19107, United States
Toledo Clinic Cancer Centers-Bowling Green

Bowling Green, Ohio, 43402, United States
Toledo Clinic Cancer Centers-Maumee

Maumee, Ohio, 43537, United States
Toledo Clinic Cancer Centers-Monroe

Monroe, Michigan, 48162, United States
Toledo Clinic Cancer Centers-Oregon

Oregon, Ohio, 43616, United States
Toledo Clinic Cancer Centers-Toledo

Toledo, Ohio, 43623, United States
Toledo Community Hospital Oncology Program CCOP

Toledo, Ohio, 43617, United States
Toledo Radiation Oncology at Northwest Ohio Onocolgy Center

Maumee, Ohio, 43537, United States
Trinity Medical Center

Moline, Illinois, 61265, United States
Tufts Medical Center

Boston, Massachusetts, 02111, United States
UT Southwestern/Simmons Cancer Center-Dallas

Dallas, Texas, 75390, United States
United Hospital

Saint Paul, Minnesota, 55102, United States
Unity Hospital

Fridley, Minnesota, 55432, United States
University of New Mexico Cancer Center

Albuquerque, New Mexico, 87102, United States
University of Pennsylvania/Abramson Cancer Center

Philadelphia, Pennsylvania, 19104, United States
University of Toledo

Toledo, Ohio, 43614, United States
University of Virginia Cancer Center

Charlottesville, Virginia, 22908, United States
Vanderbilt University/Ingram Cancer Center

Nashville, Tennessee, 37232, United States
Vanderbilt-Ingram Cancer Center Cool Springs

Franklin, Tennessee, 37067, United States
Veterans Adminstration New Jersey Health Care System

East Orange, New Jersey, 07018-1095, United States
Via Christi Regional Medical Center

Wichita, Kansas, 67214, United States
WellSpan Health-York Hospital

York, Pennsylvania, 17403, United States
Wellmont Medical Associates Oncology and Hematology-Bristol

Bristol, Tennessee, 37620, United States
West Michigan Cancer Center

Kalamazoo, Michigan, 49007, United States
West Virginia University Charleston

Charleston, West Virginia, 25304, United States
West Virginia University Healthcare

Morgantown, West Virginia, 26506, United States
Wheeling Hospital/Schiffler Cancer Center

Wheeling, West Virginia, 26003, United States
Wichita NCI Community Oncology Research Program

Wichita, Kansas, 67214, United States

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