New radiation technique aims to protect memory in lung cancer patients

NCT ID NCT02635009

Disease control Sponsor: NRG Oncology Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jul 10, 2026 · Updated 2 times

Summary

This study tested whether avoiding the hippocampus during whole-brain radiation could reduce memory side effects in people with small cell lung cancer. Over 400 patients received either standard whole-brain radiation or a version that spares the hippocampus. The goal was to see if the memory-sparing approach leads to less cognitive decline while still preventing brain metastases.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance: radiation therapy (whole-brain radiation with or without hippocampal avoidance)
What this could lead to: If successful, this approach could reduce memory and thinking problems after brain radiation for small cell lung cancer, while still preventing cancer spread to the brain.
What could go wrong: This is a completed trial, but results may not apply to all patients. The technique requires precise planning and may not prevent all cognitive decline or brain relapses.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 2/3

Runs two stages together: whether the treatment works, then large-scale confirmation.

Participants

418 people

The number who actually took part.

Started

Dec 2015

Finished

Sep 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria \[prior to Step 1 registration\]: * Histologic proof or unequivocal cytologic proof (fine needle aspiration, biopsy or two positive sputa) of SCLC within 250 days prior to Step 1 registration * High-grade neuroendocrine carcinoma or combined SCLC and NSCLC is permitted. * Patients must have received chemotherapy and be registered to Step 1 registration no earlier than 7 days and no later than 56 days after completing chemotherapy. Note: * Post-chemotherapy restaging imaging must be completed no more than 56 days prior to Step 1 registration. * For patients with extensive-stage small cell lung cancer who are being considered for consolidative thoracic radiotherapy after chemotherapy, concomitant administration of consolidative thoracic radiotherapy and protocol-specified prophylactic cranial irradiation with or without hippocampal avoidance is permitted. * Patients must have a gadolinium contrast-enhanced three-dimensional (3D), spoiled gradient (SPGR), magnetization-prepared rapid gradient echo (MP-RAGE), or turbo field echo (TFE) MRI scan. To yield acceptable image quality, the gadolinium contrast-enhanced three-dimensional SPGR, MP-RAGE or TFE axial MRI scan must use the smallest possible axial slice thickness not exceeding 1.5 mm. * This MRI must be obtained within 56 days prior to Step 1 registration. Note: The MRI study is mandatory irrespective of randomization to the experimental or control arm of this study. * Prior to chemotherapy +/- thoracic radiotherapy, patients must be defined as limited-stage or extensive-stage SCLC after clinical staging evaluation involving the following: 1. History/physical examination; 2. CT of the chest and abdomen with contrast (does not have to be done if the patient has had a positron emission tomography (PET) / CT scan prior to initiating chemotherapy or thoracic radiotherapy); 3. MRI of the brain with contrast or diagnostic head CT with contrast; 4. For patients without evidence of extensive-stage SCLC on chest and abdomen CT and brain MRI or head CT, a PET/CT or bone scan is required to confirm limited-stage SCLC. * After chemotherapy, patients must be restaged prior to Step 1 registration using the same diagnostic work-up as required pre-chemotherapy. Repeat PET/CT or bone scan is not required. Patients must have: * History/physical examination within 30 days of Step 1 registration; * No CNS metastases (Repeat MRI required) within 56 days prior to Step 1 registration; * No progression in any site; * Radiographic partial or complete response to chemotherapy in at least one disease site within 56 days prior to Step 1 registration. 1. If PET/CT was obtained prior to chemotherapy, either a repeat PET/CT or CT of the chest and abdomen with contrast can be obtained for response assessment. 2. Patients who underwent resection for limited-stage SCLC prior to chemotherapy and have no radiographically evident disease for response assessment remain eligible if post-chemotherapy imaging demonstrates no progression. * Zubrod performance status 0-2 within 30 days prior to Step 1 registration. * Women of childbearing potential must have a negative qualitative serum pregnancy test =\< 14 days prior to Step 1 registration. * Patients who are primary English or French speakers are eligible * Patients must sign a study-specific informed consent prior to study entry Inclusion Criteria \[prior to Step 2 registration\]: * The following baseline neurocognitive assessments must be completed and uploaded within 10 calendar days after or at the time of Step 1 registration: HVLT-R (recall, delayed recall, and recognition), TMT (Parts A and B), and COWA. The neurocognitive assessments will be uploaded into the NRG Oncology Rave System for evaluation by Neurocognitive Co-Chair. Once the upload is complete, within 3 business days, a notification email will be sent to the site to proceed to Step 2 registration. At minimum, the HVLT-R delayed recall must be able to be scored (i.e. completed without error) in order to be eligible. * Patients must have a baseline raw score greater than 2 on the HVLT-R delayed recall as determined by central assessment by the Neurocognitive Co-Chair. Exclusion Criteria: * Prior radiotherapy to the head or neck (except for T1 glottic cancer), resulting in overlap of radiation fields * Radiographic evidence of central nervous system (CNS) metastases * Radiographic evidence of hydrocephalus or other architectural distortion of the ventricular system, including placement of external ventricular drain or ventriculoperitoneal shunt * Planned concurrent chemotherapy during PCI * Concurrent atezolizumab permitted * Concomitant invasive malignancy or invasive malignancy within the past five years other than non-melanomatous skin cancer; history of in situ carcinoma (e.g. ductal carcinoma in situ of breast, in situ carcinoma of the cervix, vulva or larynx) is permitted * Contraindication to MR imaging, such as implanted metal devices or foreign bodies or severe claustrophobia * Severe, active comorbidity, defined as follows: * Unstable angina and/or congestive heart failure requiring hospitalization within the last 6 months * Transmural myocardial infarction within the last 6 months * Acute bacterial or fungal infection requiring intravenous antibiotics at the time of registration * Hepatic insufficiency resulting in clinical jaundice and/or coagulation defects * Chronic obstructive pulmonary disease exacerbation or other respiratory illness requiring hospitalization or precluding study therapy at the time of registration * Uncontrolled, clinically significant cardiac arrhythmias * HIV positive with CD4 count \< 200 cells/microliter; 1. Note: Patients who are HIV positive are eligible, provided they are under treatment with highly active antiretroviral therapy (HAART) and have a CD4 count ≥ 200 cells/microliter within 30 days prior to Step 1 registration. 2. Note: HIV testing is not required for eligibility for this protocol. * Pregnant or lactating women or women of childbearing potential and male participants who are sexually active and not willing/able to use medically acceptable forms of contraception; this exclusion is necessary because the radiation treatment involved in this study may be significantly teratogenic.

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Conditions

The condition(s) this trial relates to.

small cell lung carcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Extensive stage small cell lung carcinoma Limited stage small cell lung carcinoma

Contacts and locations

Locations

Abbott-Northwestern Hospital

Minneapolis, Minnesota, 55407, United States
Adams Cancer Center

Gettysburg, Pennsylvania, 17325, United States
Adena Regional Medical Center

Chillicothe, Ohio, 45601, United States
Allan Blair Cancer Centre

Regina, Saskatchewan, S4T 7T1, Canada
AnMed Health Cancer Center

Anderson, South Carolina, 29621, United States
Arnot Ogden Medical Center/Falck Cancer Center

Elmira, New York, 14905, United States
Ascension All Saints Hospital

Racine, Wisconsin, 53405, United States
Ascension Saint Francis - Reiman Cancer Center

Franklin, Wisconsin, 53132, United States
Ascension Saint Vincent Anderson

Anderson, Indiana, 46016, United States
Ascension Southeast Wisconsin Hospital - Elmbrook Campus

Brookfield, Wisconsin, 53045, United States
Ascension Via Christi Hospitals Wichita

Wichita, Kansas, 67214, United States
Aspirus Cancer Care - Wisconsin Rapids

Wisconsin Rapids, Wisconsin, 54494, United States
Aspirus Regional Cancer Center

Wausau, Wisconsin, 54401, United States
Atrium Health Cabarrus/LCI-Concord

Concord, North Carolina, 28025, United States
Atrium Health Cleveland/LCI-Cleveland

Shelby, North Carolina, 28150, United States
Atrium Health Pineville/LCI-Pineville

Charlotte, North Carolina, 28210, United States
Atrium Health Union/LCI-Union

Monroe, North Carolina, 28112, United States
Atrium Health University City/LCI-University

Charlotte, North Carolina, 28262, United States
Aurora BayCare Medical Center

Green Bay, Wisconsin, 54311, United States
Aurora Cancer Care-Grafton

Grafton, Wisconsin, 53024, United States
Aurora Cancer Care-Kenosha South

Kenosha, Wisconsin, 53142, United States
Aurora Medical Center in Summit

Summit, Wisconsin, 53066, United States
Aurora Saint Luke's Medical Center

Milwaukee, Wisconsin, 53215, United States
Aurora Sinai Medical Center

Milwaukee, Wisconsin, 53233, United States
Aurora West Allis Medical Center

West Allis, Wisconsin, 53227, United States
Banner University Medical Center - Tucson

Tucson, Arizona, 85719, United States
Benefis Sletten Cancer Institute

Great Falls, Montana, 59405, United States
Billings Clinic Cancer Center

Billings, Montana, 59101, United States
Blount Memorial Hospital

Maryville, Tennessee, 37804, United States
Boca Raton Regional Hospital

Boca Raton, Florida, 33486, United States
Broward Health Medical Center

Fort Lauderdale, Florida, 33316, United States
Bryn Mawr Hospital

Bryn Mawr, Pennsylvania, 19010, United States
CHU de Quebec-L'Hotel-Dieu de Quebec (HDQ)

Québec, Quebec, G1R 2J6, Canada
CHUM - Centre Hospitalier de l'Universite de Montreal

Montreal, Quebec, H2X 3E4, Canada
California Pacific Medical Center-Pacific Campus

San Francisco, California, 94115, United States
Carle Cancer Center

Urbana, Illinois, 61801, United States
Carolinas Medical Center/Levine Cancer Institute

Charlotte, North Carolina, 28203, United States
Case Western Reserve University

Cleveland, Ohio, 44106, United States
Central Maryland Radiation Oncology in Howard County

Columbia, Maryland, 21044, United States
Central Vermont Medical Center/National Life Cancer Treatment

Berlin Corners, Vermont, 05602, United States
Centre Hospitalier Universitaire de Sherbrooke-Fleurimont

Sherbrooke, Quebec, J1H 5N4, Canada
Chelsea Hospital

Chelsea, Michigan, 48118, United States
Christiana Care Health System-Christiana Hospital

Newark, Delaware, 19718, United States
Christiana Care Health System-Concord Health Center

Chadds Ford, Pennsylvania, 19317, United States
Cleveland Clinic Akron General

Akron, Ohio, 44307, United States
Cleveland Clinic Cancer Center Independence

Independence, Ohio, 44131, United States
Cleveland Clinic Cancer Center Strongsville

Strongsville, Ohio, 44136, United States
Cleveland Clinic Cancer Center/Fairview Hospital

Cleveland, Ohio, 44111, United States
Cleveland Clinic Foundation

Cleveland, Ohio, 44195, United States
Cleveland Clinic Wooster Family Health and Surgery Center

Wooster, Ohio, 44691, United States
Community Medical Center

Missoula, Montana, 59804, United States
Condell Memorial Hospital

Libertyville, Illinois, 60048, United States
Corewell Health Beaumont Troy Hospital

Troy, Michigan, 48085, United States
Corewell Health Dearborn Hospital

Dearborn, Michigan, 48124, United States
Corewell Health Grand Rapids Hospitals - Butterworth Hospital

Grand Rapids, Michigan, 49503, United States
Corewell Health Lakeland Hospitals - Saint Joseph Hospital

Saint Joseph, Michigan, 49085, United States
Corewell Health William Beaumont University Hospital

Royal Oak, Michigan, 48073, United States
Covenant Health Cancer Centers

Knoxville, Tennessee, 37916, United States
Crossroads Cancer Center

Effingham, Illinois, 62401, United States
Crozer Regional Cancer Center at Brinton Lake

Glen Mills, Pennsylvania, 19342, United States
Crozer-Keystone Regional Cancer Center at Broomall

Broomall, Pennsylvania, 19008, United States
Dartmouth Cancer Center - North

Saint Johnsbury, Vermont, 05819, United States
Dartmouth Hitchcock Medical Center/Dartmouth Cancer Center

Lebanon, New Hampshire, 03756, United States
Dayton Physician LLC - Englewood

Dayton, Ohio, 45415, United States
Decatur Memorial Hospital

Decatur, Illinois, 62526, United States
Edward Hines Jr VA Hospital

Hines, Illinois, 60141, United States
Emory University Hospital Midtown

Atlanta, Georgia, 30308, United States
Emory University Hospital/Winship Cancer Institute

Atlanta, Georgia, 30322, United States
Englewood Hospital and Medical Center

Englewood, New Jersey, 07631, United States
Fox Chase Cancer Center

Philadelphia, Pennsylvania, 19111, United States
Freeman Health System

Joplin, Missouri, 64804, United States
Froedtert Menomonee Falls Hospital

Menomonee Falls, Wisconsin, 53051, United States
Geauga Hospital

Chardon, Ohio, 44024, United States
Geisinger Medical Center

Danville, Pennsylvania, 17822, United States
Geisinger Medical Oncology-Lewisburg

Lewisburg, Pennsylvania, 17837, United States
Geisinger Wyoming Valley/Henry Cancer Center

Wilkes-Barre, Pennsylvania, 18711, United States
Gene Upshaw Memorial Tahoe Forest Cancer Center

Truckee, California, 96161, United States
Genesys Hurley Cancer Institute

Flint, Michigan, 48503, United States
Goshen Center for Cancer Care

Goshen, Indiana, 46526, United States
Grady Health System

Atlanta, Georgia, 30303, United States
Gundersen Lutheran Medical Center

La Crosse, Wisconsin, 54601, United States
Hartford HealthCare - Saint Vincent's Medical Center

Bridgeport, Connecticut, 06606, United States
Helen F Graham Cancer Center

Newark, Delaware, 19713, United States
Henry Ford Cancer Institute-Downriver

Brownstown, Michigan, 48183, United States
Henry Ford Hospital

Detroit, Michigan, 48202, United States
Henry Ford Macomb Hospital-Clinton Township

Clinton Township, Michigan, 48038, United States
Henry Ford West Bloomfield Hospital

West Bloomfield, Michigan, 48322, United States
Huntsman Cancer Institute/University of Utah

Salt Lake City, Utah, 84112, United States
IU Health Ball Memorial Hospital

Muncie, Indiana, 47303, United States
Illinois CancerCare-Peoria

Peoria, Illinois, 61615, United States
Iowa Methodist Medical Center

Des Moines, Iowa, 50309, United States
Jefferson Abington Hospital

Abington, Pennsylvania, 19001, United States
Jefferson Torresdale Hospital

Philadelphia, Pennsylvania, 19114, United States
John H Stroger Jr Hospital of Cook County

Chicago, Illinois, 60612, United States
Johns Hopkins University/Sidney Kimmel Cancer Center

Baltimore, Maryland, 21287, United States
Kaiser Permanente Medical Center - Santa Clara

Santa Clara, California, 95051, United States
Kaiser Permanente Oakland-Broadway

Oakland, California, 94611, United States
Kaiser Permanente-Rancho Cordova Cancer Center

Rancho Cordova, California, 95670, United States
Kingston Health Sciences Centre

Kingston, Ontario, K7L 2V7, Canada
Lahey Hospital and Medical Center

Burlington, Massachusetts, 01805, United States
Lancaster Radiation Therapy Center

Lancaster, South Carolina, 29720, United States
Langlade Hospital and Cancer Center

Antigo, Wisconsin, 54409, United States
Lankenau Medical Center

Wynnewood, Pennsylvania, 19096, United States
Lawrence Memorial Hospital

Lawrence, Kansas, 66044, United States
Legacy Good Samaritan Hospital and Medical Center

Portland, Oregon, 97210, United States
Legacy Mount Hood Medical Center

Gresham, Oregon, 97030, United States
Lenox Hill Hospital

New York, New York, 10075, United States
Lewis Cancer and Research Pavilion at Saint Joseph's/Candler

Savannah, Georgia, 31405, United States
Lewis and Faye Manderson Cancer Center

Tuscaloosa, Alabama, 35401, United States
London Regional Cancer Program

London, Ontario, N6A 4L6, Canada
Los Angeles General Medical Center

Los Angeles, California, 90033, United States
Lowell General Hospital

Lowell, Massachusetts, 01854, United States
Loyola University Medical Center

Maywood, Illinois, 60153, United States
Luminis Health Anne Arundel Medical Center

Annapolis, Maryland, 21401, United States
Marin General Hospital

Greenbrae, California, 94904, United States
Marshfield Medical Center - Weston

Weston, Wisconsin, 54476, United States
Marshfield Medical Center-River Region at Stevens Point

Stevens Point, Wisconsin, 54482, United States
Mayo Clinic Health System Eau Claire Hospital-Luther Campus

Eau Claire, Wisconsin, 54703, United States
Mayo Clinic Health System in Albert Lea

Albert Lea, Minnesota, 56007, United States
Mayo Clinic Health System-Eau Claire Clinic

Eau Claire, Wisconsin, 54701, United States
Mayo Clinic Health System-Franciscan Healthcare

La Crosse, Wisconsin, 54601, United States
Mayo Clinic Health Systems-Mankato

Mankato, Minnesota, 56001, United States
Mayo Clinic Radiation Therapy-Northfield

Northfield, Minnesota, 55057, United States
Mayo Clinic in Rochester

Rochester, Minnesota, 55905, United States
McLaren Cancer Institute-Bay City

Bay City, Michigan, 48706, United States
McLaren Cancer Institute-Central Michigan

Mount Pleasant, Michigan, 48858, United States
McLaren Cancer Institute-Clarkston

Clarkston, Michigan, 48346, United States
McLaren Cancer Institute-Flint

Flint, Michigan, 48532, United States
McLaren Cancer Institute-Lapeer Region

Lapeer, Michigan, 48446, United States
McLaren Cancer Institute-Macomb

Mount Clemens, Michigan, 48043, United States
McLaren Cancer Institute-Northern Michigan

Petoskey, Michigan, 49770, United States
McLaren Cancer Institute-Owosso

Owosso, Michigan, 48867, United States
McLaren-Port Huron

Port Huron, Michigan, 48060, United States
MedStar Franklin Square Medical Center/Weinberg Cancer Institute

Baltimore, Maryland, 21237, United States
MedStar Good Samaritan Hospital

Baltimore, Maryland, 21239, United States
Medical College of Wisconsin

Milwaukee, Wisconsin, 53226, United States
Memorial Health University Medical Center

Savannah, Georgia, 31404, United States
Memorial Sloan Kettering Basking Ridge

Basking Ridge, New Jersey, 07920, United States
Memorial Sloan Kettering Bergen

Montvale, New Jersey, 07645, United States
Memorial Sloan Kettering Cancer Center

New York, New York, 10065, United States
Memorial Sloan Kettering Commack

Commack, New York, 11725, United States
Memorial Sloan Kettering Monmouth

Middletown, New Jersey, 07748, United States
Memorial Sloan Kettering Nassau

Uniondale, New York, 11553, United States
Memorial Sloan Kettering Westchester

Harrison, New York, 10604, United States
Mercy Cancer Center

Merced, California, 95340, United States
Mercy Cancer Center-Elyria

Elyria, Ohio, 44035, United States
Mercy Hospital

Cedar Rapids, Iowa, 52403, United States
Mercy Hospital Saint Louis

St Louis, Missouri, 63141, United States
Methodist Medical Center of Illinois

Peoria, Illinois, 61636, United States
Miami Cancer Institute

Miami, Florida, 33176, United States
Michigan Healthcare Professionals Clarkston

Clarkston, Michigan, 48346, United States
Michigan Healthcare Professionals Farmington

Farmington Hills, Michigan, 48334, United States
Michigan Healthcare Professionals Macomb

Macomb, Michigan, 48044, United States
Michigan Healthcare Professionals Troy

Troy, Michigan, 48098, United States
Missouri Baptist Medical Center

St Louis, Missouri, 63131, United States
Moffitt Cancer Center

Tampa, Florida, 33612, United States
Montefiore Medical Center - Moses Campus

The Bronx, New York, 10467, United States
Montefiore Medical Center-Einstein Campus

The Bronx, New York, 10461, United States
Mount Carmel Health Center West

Columbus, Ohio, 43222, United States
NYP/Columbia University Medical Center/Herbert Irving Comprehensive Cancer Center

New York, New York, 10032, United States
New York-Presbyterian/Brooklyn Methodist Hospital

Brooklyn, New York, 11215, United States
North Kansas City Hospital

Kansas City, Missouri, 64116, United States
Northeast Radiation Oncology Center

Dunmore, Pennsylvania, 18512, United States
Northside Hospital

Atlanta, Georgia, 30342, United States
Northside Hospital-Forsyth

Cumming, Georgia, 30041, United States
Northwell Health Imbert Cancer Center

Bay Shore, New York, 11706, United States
Northwell Health/Center for Advanced Medicine

Lake Success, New York, 11042, United States
Northwestern Medicine Cancer Center Delnor

Geneva, Illinois, 60134, United States
Northwestern Medicine Cancer Center Warrenville

Warrenville, Illinois, 60555, United States
Northwestern University

Chicago, Illinois, 60611, United States
OSF Saint Francis Medical Center

Peoria, Illinois, 61637, United States
Ogden Regional Medical Center

Ogden, Utah, 84405, United States
Ohio State University Comprehensive Cancer Center

Columbus, Ohio, 43210, United States
Orlando Health Cancer Institute

Orlando, Florida, 32806, United States
Ottawa Hospital and Cancer Center-General Campus

Ottawa, Ontario, K1H 8L6, Canada
Park Nicollet Clinic - Saint Louis Park

Saint Louis Park, Minnesota, 55416, United States
Parkview Hospital Randallia

Fort Wayne, Indiana, 46805, United States
Parkview Regional Medical Center

Fort Wayne, Indiana, 46845, United States
Penn State Health Saint Joseph Medical Center

Reading, Pennsylvania, 19605, United States
Piedmont Hospital

Atlanta, Georgia, 30309, United States
Poudre Valley Hospital

Fort Collins, Colorado, 80524, United States
Prisma Health Cancer Institute - Eastside

Greenville, South Carolina, 29615, United States
Prisma Health Cancer Institute - Faris

Greenville, South Carolina, 29605, United States
Prisma Health Cancer Institute - Spartanburg

Boiling Springs, South Carolina, 29316, United States
Queen's Medical Center

Honolulu, Hawaii, 96813, United States
Rapid City Regional Hospital

Rapid City, South Dakota, 57701, United States
Reading Hospital

West Reading, Pennsylvania, 19611, United States
Renown Regional Medical Center

Reno, Nevada, 89502, United States
Riddle Memorial Hospital

Media, Pennsylvania, 19063, United States
Rock Hill Radiation Therapy Center

Rock Hill, South Carolina, 29730, United States
Roswell Park Cancer Institute

Buffalo, New York, 14263, United States
Rush MD Anderson Cancer Center

Chicago, Illinois, 60612, United States
Saint Alphonsus Cancer Care Center-Boise

Boise, Idaho, 83706, United States
Saint Alphonsus Cancer Care Center-Caldwell

Caldwell, Idaho, 83605, United States
Saint Alphonsus Cancer Care Center-Nampa

Nampa, Idaho, 83687, United States
Saint Francis Medical Center

Cape Girardeau, Missouri, 63703, United States
Saint Joseph Hospital - Orange

Orange, California, 92868, United States
Saint Luke's Cancer Institute - Boise

Boise, Idaho, 83712, United States
Saint Luke's Cancer Institute - Meridian

Meridian, Idaho, 83642, United States
Saint Luke's Cancer Institute - Nampa

Nampa, Idaho, 83687, United States
Saint Luke's Cancer Institute - Twin Falls

Twin Falls, Idaho, 83301, United States
Saint Luke's Hospital

Cedar Rapids, Iowa, 52402, United States
Saint Luke's Hospital of Duluth

Duluth, Minnesota, 55805, United States
Saint Luke's Hospital of Kansas City

Kansas City, Missouri, 64111, United States
Sanford Bismarck Medical Center

Bismarck, North Dakota, 58501, United States
Sanford Roger Maris Cancer Center

Fargo, North Dakota, 58122, United States
Sanford USD Medical Center - Sioux Falls

Sioux Falls, South Dakota, 57117-5134, United States
Saskatoon Cancer Centre

Saskatoon, Saskatchewan, S7N 4H4, Canada
Self Regional Healthcare

Greenwood, South Carolina, 29646, United States
Siteman Cancer Center at West County Hospital

Creve Coeur, Missouri, 63141, United States
Siteman Cancer Center-South County

St Louis, Missouri, 63129, United States
Springfield Memorial Hospital

Springfield, Illinois, 62781, United States
State University of New York Upstate Medical University

Syracuse, New York, 13210, United States
Staten Island University Hospital

Staten Island, New York, 10305, United States
Stronach Regional Health Centre at Southlake

Newmarket, Ontario, L3Y 2P9, Canada
Summa Health System - Akron Campus

Akron, Ohio, 44304, United States
Sutter Cancer Centers Radiation Oncology Services-Roseville

Roseville, California, 95661, United States
Sutter Medical Center Sacramento

Sacramento, California, 95816, United States
Sutter Solano Medical Center/Cancer Center

Vallejo, California, 94589, United States
Swedish Medical Center

Englewood, Colorado, 80113, United States
Temple University Hospital

Philadelphia, Pennsylvania, 19140, United States
The Cancer Center of Hawaii-Liliha

Honolulu, Hawaii, 96817, United States
The Cancer Center of Hawaii-Pali Momi

‘Aiea, Hawaii, 96701, United States
The Permanente Medical Group-Roseville Radiation Oncology

Roseville, California, 95678, United States
The Radiation Oncology Center-Hilton Head/Bluffton

Hilton Head Island, South Carolina, 29926, United States
The Research Institute of the McGill University Health Centre (MUHC)

Montreal, Quebec, H3H 2R9, Canada
Thomas Jefferson University Hospital

Philadelphia, Pennsylvania, 19107, United States
TidalHealth Peninsula Regional

Salisbury, Maryland, 21801, United States
TidalHealth Richard A Henson Cancer Institute

Ocean Pines, Maryland, 21811, United States
Trinity Health Grand Rapids Hospital

Grand Rapids, Michigan, 49503, United States
Trinity Health Medical Center - Brighton

Brighton, Michigan, 48114, United States
Trinity Health Muskegon Hospital

Muskegon, Michigan, 49444, United States
Trinity Health Saint Joseph Mercy Hospital Ann Arbor

Ann Arbor, Michigan, 48106, United States
Trinity Health Saint Joseph Mercy Oakland Hospital

Pontiac, Michigan, 48341, United States
Trinity Health Saint Mary Mercy Livonia Hospital

Livonia, Michigan, 48154, United States
Tulane University School of Medicine

New Orleans, Louisiana, 70112, United States
UH Seidman Cancer Center at Lake Health Mentor Campus

Mentor, Ohio, 44060, United States
UH Seidman Cancer Center at Southwest General Hospital

Middleburg Heights, Ohio, 44130, United States
UHHS-Westlake Medical Center

Westlake, Ohio, 44145, United States
UM Baltimore Washington Medical Center/Tate Cancer Center

Glen Burnie, Maryland, 21061, United States
UM Saint Joseph Medical Center

Towson, Maryland, 21204, United States
UM Sylvester Comprehensive Cancer Center at Coral Gables

Coral Gables, Florida, 33146, United States
UM Upper Chesapeake Medical Center

Bel Air, Maryland, 21014, United States
UMass Memorial Medical Center - University Campus

Worcester, Massachusetts, 01655, United States
USC / Norris Comprehensive Cancer Center

Los Angeles, California, 90033, United States
UT MD Anderson Cancer Center

Houston, Texas, 77030, United States
UTMB Cancer Center at Victory Lakes

League City, Texas, 77573, United States
University Health Network-Princess Margaret Hospital

Toronto, Ontario, M5G 2M9, Canada
University Hospitals Parma Medical Center

Parma, Ohio, 44129, United States
University of Alabama at Birmingham Cancer Center

Birmingham, Alabama, 35233, United States
University of California Davis Comprehensive Cancer Center

Sacramento, California, 95817, United States
University of Kansas Cancer Center

Kansas City, Kansas, 66160, United States
University of Kansas Cancer Center - North

Kansas City, Missouri, 64154, United States
University of Kansas Cancer Center at North Kansas City Hospital

North Kansas City, Missouri, 64116, United States
University of Kansas Cancer Center-Overland Park

Overland Park, Kansas, 66210, United States
University of Kentucky/Markey Cancer Center

Lexington, Kentucky, 40536, United States
University of Maryland/Greenebaum Cancer Center

Baltimore, Maryland, 21201, United States
University of Miami Miller School of Medicine-Sylvester Cancer Center

Miami, Florida, 33136, United States
University of Nebraska Medical Center

Omaha, Nebraska, 68198, United States
University of New Mexico Cancer Center

Albuquerque, New Mexico, 87106, United States
University of Oklahoma Health Sciences Center

Oklahoma City, Oklahoma, 73104, United States
University of Rochester

Rochester, New York, 14642, United States
University of Texas Medical Branch

Galveston, Texas, 77555-0565, United States
University of Vermont Medical Center

Burlington, Vermont, 05401, United States
University of Wisconsin Carbone Cancer Center - Johnson Creek

Johnson Creek, Wisconsin, 53038, United States
University of Wisconsin Carbone Cancer Center - University Hospital

Madison, Wisconsin, 53792, United States
VCU Massey Comprehensive Cancer Center

Richmond, Virginia, 23298, United States
Vanderbilt University/Ingram Cancer Center

Nashville, Tennessee, 37232, United States
Vince Lombardi Cancer Clinic - Oshkosh

Oshkosh, Wisconsin, 54904, United States
Vince Lombardi Cancer Clinic-Two Rivers

Two Rivers, Wisconsin, 54241, United States
Virtua Memorial

Mount Holly, New Jersey, 08060, United States
Virtua Voorhees

Voorhees Township, New Jersey, 08043, United States
Washington University School of Medicine

St Louis, Missouri, 63110, United States
Wayne State University/Karmanos Cancer Institute

Detroit, Michigan, 48201, United States
WellSpan Health-York Cancer Center

York, Pennsylvania, 17403, United States
Wentworth-Douglass Hospital

Dover, New Hampshire, 03820, United States
Wesley Medical Center

Wichita, Kansas, 67214, United States
West Michigan Cancer Center

Kalamazoo, Michigan, 49007, United States
West Virginia University Healthcare

Morgantown, West Virginia, 26506, United States
Wheeling Hospital/Schiffler Cancer Center

Wheeling, West Virginia, 26003, United States
Yale University

New Haven, Connecticut, 06520, United States

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