Can a simple exercise program help those with COPD, sleep apnea, or long COVID?
NCT ID NCT05395390
First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 2 times
Summary
This study looked at how a mix of home and on-site resistance training affects muscle loss and fatigue in people with chronic respiratory diseases like COPD, obstructive sleep apnea, or lingering COVID-19 symptoms. 72 adults aged 30-85 completed 18 exercise sessions. Researchers measured changes in protein metabolism and body composition to see if the program helps.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- Exercise (resistance training with dumbbells or machines)
- What this could lead to
- If successful, this could point toward a practical exercise program to reduce muscle loss and fatigue in people with chronic respiratory conditions.
- What could go wrong
- This is a small, completed study (72 people) focused on measuring body responses, not proving long-term benefits. Results may not apply to everyone.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
-
Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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72 people
The number who actually took part.
- Started
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Feb 2021
- Finished
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Aug 2023
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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30 to 85 years
- Sex
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Anyone
- Healthy volunteers
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Accepted
You do not need to have the condition being studied to take part.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Ability to walk, sit down and stand up independently * Age 30 - 85 years * Ability to lay in supine or elevated position for up to 3 hours * Diagnosis of moderate to very severe chronic airflow limitation and compliant to the following criteria: FEV1 \< 70% of reference FEV1 -or- Obstructive Sleep Apnea (OSA) -or- 2 weeks post-recovered\* from laboratory confirmed case of COVID ● Willingness and ability to comply with the protocol \*Recovered is defined according to Brazos County Health District as someone who has been fever-free for 24 hours without fever-reducing medications, and it has been 10 days after onset of symptoms. Inclusion criteria control subjects * Healthy male or female according to the investigator's or appointed staff's judgment * Ability to walk, sit down and stand up independently * Age 30 - 85 years * Ability to lay in supine or elevated position for up to 3 hours * No diagnosis of chronic lung disease * Willingness and ability to comply with the protocol Exclusion Criteria: * Unable to exercise due to physical limitations (i.e. neuromuscular and/or orthopedic disorders) * Established diagnosis of malignancy * Presence of acute illness or metabolically unstable chronic illness * Presence of fever within the last 3 days. * Expected to have surgery within 1 month of screening or during exercise training * Any other condition according to the PI or research staff that was found during the screening visit, that would interfere with the study or safety of the patient. * Previous injury that could interfere with participation in resistance exercise protocol. * Failure to give informed consent or Investigator's uncertainty about the willingness or ability of the subject to comply with the protocol requirements. * (Possible) pregnancy. * Already enrolled in another clinical trial and that clinical trial interferes with participating in this study. When during the period from enrollment to the test day any condition causing the subject to not meet inclusion criteria or to meet exclusion criteria, the subject will be excluded from the study.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Texas A&M University
College Station, Texas, 77843, United States
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