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Late meals, Off-Beat sleep: could timing be key to weight control?

NCT ID NCT03663530

What the study statuses mean

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Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 26, 2026 · Last updated Jun 26, 2026

Summary

This study looks at how eating and sleeping at mismatched times (like shift workers do) affects weight regulation. Researchers will track 42 adults with overweight or obesity, measuring energy use, body composition, and brain responses to food. The goal is to understand whether aligning meal and sleep times helps control weight, independent of how long you sleep.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If successful, this study could provide clear guidance on how timing meals and sleep can help manage weight, especially for shift workers or people with jet lag.
What could go wrong
This is a small, early-stage observational study (42 participants) that measures effects over a short period. Results may not apply to everyone, and it does not test a treatment or intervention.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 42 people

The number the study aims to enrol. It can still change while the study runs.

Started

Jan 2019

Expected to finish

Dec 2026

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

20 to 49 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * All racial and ethnic groups * Body mass index 20-34.9 kg/m2 * Average sleep duration ≥7 hour/night, assessed during 2-week screening period * Eat within 1 hour of awakening at least 5 days/week * Midpoint of sleep at 4 AM or earlier Exclusion Criteria: * \<10 nights of sleep \<7 hour during the 2-week screening period * Daytime napping * Current or past sleep disorder (Sleep Disorders Inventory); Insomnia Severity Index Score \>10 * Current or past psychiatric disorder, including eating disorders and seasonal affective disorder * Any psychological or psychiatric disorder deemed to interfere with study outcomes * Smoking (currently smoking any cigarettes or using tobacco products, e-cigarettes and vapes, or ex-smokers \<3 years) * Night and rotating shift work * Travel across time zones within 4 wk of the study * History of drug or alcohol abuse or excessive alcohol consumption (\>3 drinks/day for men or 2 for women) * Recent weight change (\>5% gain or loss of body weight over past 3 months) or active participation in diet or weight loss program in previous 3 months; any weight loss procedure * Pregnancy or \<1 year post-partum * Diagnosed sleep apnea or high-risk score on Berlin questionnaire (2 or more categories with positive score) * Depression (score \>13 on Beck Depression Inventory II) or taking anti-depressive medications * Restless leg syndrome and circadian rhythm disorders * Dementia or cognitive impairments * Taking psychoactive or hypnotic medications * Taking chronic analgesic or anti-inflammatory medications * Having had gastrointestinal surgery, including gastric bypass surgery * Restrained eating or abnormal scores on the Three Factor Eating Questionnaire * Contraindications for magnetic resonance imaging scanning * Hematocrit \<30% * Taking beta blockers, as this can interfere with melatonin secretion

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Conditions

The condition(s) this trial relates to.

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

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Contacts and locations

Locations

  • Columbia University Irving Medical Center

    RECRUITING

    New York, New York, 10032, United States

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