New cancer drug targets immune system in first human test
NCT ID NCT04374877
Summary
This early-stage study tested the safety and initial effectiveness of a new drug called CHS-388 in adults with advanced solid tumors that had stopped responding to standard treatments. The drug, an antibody designed to target a specific immune system protein (IL-27), was tested both alone and in combination with other approved cancer immunotherapies. The main goals were to find a safe dose and see if the treatment could help control cancers like kidney, liver, and lung cancer.
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Contacts and locations
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Locations
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Asan Medical Center
Seoul, 05505, South Korea
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City of Hope
Duarte, California, 91010, United States
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Cleveland Clinic
Cleveland, Ohio, 44195, United States
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Dana Farber Cancer Institute
Boston, Massachusetts, 02215, United States
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Icahn School of Medicine at Mount Sinai (ISMMS) - The Mount Sinai Hospital (MSH)
New York, New York, 10029, United States
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Moffitt Cancer Center
Tampa, Florida, 33612, United States
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National Cancer Center Singapore (NCCS)
Singapore, 169610, Singapore
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National University Hospital
Singapore, 119228, Singapore
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Roswell Park
Buffalo, New York, 14263, United States
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Seoul National University Hospital
Seoul, 03080, South Korea
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Severance Hospital
Seoul, 03722, South Korea
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South Texas Accelerated Research Therapeutics
San Antonio, Texas, 78229, United States
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The University of Texas - MD Anderson Cancer Center
Houston, Texas, 77030, United States
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UCSF Medical Center - Helen Diller Family Comprehensive Cancer Center
San Francisco, California, 94143, United States
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University of Miami Leonard M. Miller School of Medicine (UMMSM)
Miami, Florida, 33136, United States
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University of Michigan Health System (UMHS)
Ann Arbor, Michigan, 48109, United States
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University of Oklahoma Health Sciences Center (OUHSC) - Stephenson Cancer Center
Oklahoma City, Oklahoma, 73104, United States
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University of Pittsburgh Medical Center (UPMC) - Hillman Cancer Center (University of Pittsburgh Cancer Institute (UPCI))
Pittsburgh, Pennsylvania, 15232, United States
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University of Southern California (USC) - Norris Comprehensive Cancer Center
Los Angeles, California, 90033, United States
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University of Texas Southwestern Medical Center
Dallas, Texas, 75390, United States
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University of Washington
Seattle, Washington, 98195, United States
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Vanderbilt University Medical Center (VUMC)
Nashville, Tennessee, 37232, United States
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Washington University School of Medicine - St. Louis
St Louis, Missouri, 63110, United States
Conditions
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