Heart patients: when is the best time for stent placement before other surgery?
NCT ID NCT07175870
First seen Jun 26, 2026 · Last updated Jun 26, 2026
Summary
This study looks at 140 heart disease patients who also need a non-emergency surgery. Half will get a heart artery-opening procedure (PCI) before their surgery, and half will have it after. The goal is to see which timing leads to fewer heart attacks, deaths, or repeat procedures within 180 days.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- Percutaneous coronary intervention (PCI, a procedure to open blocked heart arteries)
- What this could lead to
- If it works, this could help doctors decide the best time to perform PCI in heart patients who need non-cardiac surgery, potentially reducing heart complications.
- What could go wrong
- This is a small, early-stage trial with only 140 participants, so results may not apply to all patients. The two strategies have different risks, and the best approach may depend on individual factors.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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About 140 people
The number the study aims to enrol. It can still change while the study runs.
- Expected to start
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Oct 2025
An estimate. Start dates often move.
- Expected to finish
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Aug 2029
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 to 80 years
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Age ≥18 years * Diagnosis of coronary heart disease with non-emergent indication for PCI confirmed by coronary angiography: * Non-ST-elevation acute coronary syndrome (NSTE-ACS) at low or intermediate ischemic risk * Chronic coronary syndrome (CCS) with one of the following anatomical characteristics (see Appendix 1 for definition): 1. Moderate or severe stenosis of the left main coronary artery 2. Multivessel disease involving the ostium of the left anterior descending artery 3. Three-vessel disease with ≥70% stenosis in each major epicardial vessel * Indication for time-sensitive non-cardiac surgery * Planned non-cardiac surgery under general anesthesia in the following surgical departments: thoracic surgery, gastrointestinal surgery, colorectal surgery, hepatobiliary and pancreatic surgery, or gynecology * For patients with malignant tumors requiring time-sensitive surgery: written informed consent confirming understanding and acceptance that, if randomized to the "PCI-first" group, their tumor surgery will be delayed until 90±14 days after PCI, with acknowledgement of potential risks (e.g., tumor progression, change in resectability) * Ability to understand the study requirements and sign written informed consent in the language provided by the research team Exclusion Criteria: * Age \>80 years * Severe thrombocytopenia (platelet count \<50×10⁹/L) * Cardiogenic shock, severe heart failure (NYHA class IV, Killip class IV, or LVEF ≤35%), malignant arrhythmias (including cardiac arrest, asystole, ventricular fibrillation, or sustained ventricular tachycardia), or other life-threatening conditions requiring resuscitation * Moderate-to-severe valvular heart disease, high-grade atrioventricular block, or other severe cardiac/pulmonary dysfunction incompatible with the planned surgery * Planned surgery with extremely high bleeding risk (e.g., intracranial surgery, spinal surgery, retinal surgery) * Patients with malignant tumors undergoing non-palliative surgery who are in poor general condition, defined as meeting any of the following: 1. Karnofsky performance score \<60 2. Eastern Cooperative Oncology Group (ECOG) performance status \>2 * Disease stage beyond surgical indications or estimated life expectancy \<1 year * Patients requiring emergency or urgent surgery due to critical illness * Severe renal dysfunction: serum creatinine \>442 μmol/L, GFR ≤30 mL/min/1.73 m², or currently on renal replacement therapy * Severe hepatic dysfunction: Child-Pugh class C or higher * Severe uncontrolled systemic infection * Advanced dementia with significant decline in quality of life requiring full-time care and support * Systemic thromboembolic disease (e.g., pulmonary embolism) making surgery unsuitable * Women who are pregnant, breastfeeding, or planning pregnancy during the study period * Severe, uncontrolled comorbid conditions continuously impairing physiological or psychological function * Participation in another clinical study within 3 months prior to enrollment * Any condition judged by the investigator to interfere with participation or study conduct
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The study's own enquiry address
This study publishes an address for enquiries. See it below .
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The places running it
1 site. The list below names each one and where it is.
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The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
Contacts and locations
Show contact details
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Genom att skicka in godkänner du våra Användarvillkor
Locations
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the First Affiliated Hospitalof Wenzhou Medical University
Wenzhou, Zhejiang, China
Contact Email: •••••@•••••
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