Chlorophyll-Based supplement may ease radiation damage in cervical cancer patients
NCT ID NCT07164534
First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This phase 3 trial tests whether a daily dose of sodium-copper-chlorophyllin, a chlorophyll derivative, can reduce long-term bladder and bowel side effects from radiation therapy in 316 women with locally advanced cervical cancer. Participants take the supplement for 3 months after completing standard chemoradiation. The study compares side effects at 24 months between those taking the supplement and those receiving standard follow-up care.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- sodium-copper-chlorophyllin
- What this could lead to
- If it works, this could offer a simple, short-term supplement to reduce long-term bladder and bowel damage after cervical cancer radiation, improving quality of life.
- What could go wrong
- This is a phase 3 trial, but it's not yet recruiting. The supplement may not reduce side effects as hoped, and results may not apply to all patients.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Phase 3
Large-scale testing in a bigger group. Usually the last step before a treatment can be approved.
- Participants
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About 316 people
The number the study aims to enrol. It can still change while the study runs.
- Expected to start
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Mar 2026
An estimate. Start dates often move.
- Expected to finish
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Sep 2030
An estimate. End dates often move.
- Lead sponsor
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A government agency
The lead sponsor is a government body.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 years and older
- Sex
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Female participants only
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Female subjects aged 18 years or above with histologically proven locally advanced squamous cell or adenocarcinoma of the cervix * Subjects eligible for RT and planned for definitive RT +/- chemotherapy with brachytherapy. * Subjects who exceed the dose constraints of: * Rectum/sigmoid D 2cm³ EQD2 ³ by more than 70 Gy, or * Bladder D 2cm³ EQD2 ³ more than 80 Gy * Subjects with adequate haematological, renal, hepatic and coagulation profiles and laboratory parameters within the following ranges: * Haemoglobin: ≥ 8 g/dl * ANC ≥ 1,500/mm\^3 * Platelet count 100,000/mm\^3 * Creatinine Clearance: ≥ 50 ml/min (as per Cockcroft-Gault formula) * Bilirubin: ≤ 2 x Upper limit of normal (ULN) * AST and ALT: ≤ 1.5 x ULN * Subjects willing and able to comply with all study requirements, including treatment (e.g. able to swallow tablets), timing and/or nature of required assessments * Ability to understand and willingness to sign an informed consent document Exclusion Criteria: * Subjects with known hypersensitivity or contraindication to the study drug or to any known component of the study drug formulation * Subjects with clinically significant decreased hematologic reserves, with major organ failure, severe electrolyte or metabolic abnormalities, any active infection or any other medical condition that may interfere with the ability to receive study treatment * HIV positive patients * Subjects with a history of blood dyscrasias * Subjects consuming any other concurrent investigational agents * Subjects with any other previous or current malignancy or RT that is likely to interfere with the protocol treatment, or any other condition which, according to the principal investigator, might make an individual unsuitable for this study * Subjects participating in any other clinical study within 90 days before enrolment in the study * Subjects on active anti-coagulant treatment
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
More trials for these conditions
Other studies related to the condition(s) this trial covers.
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- New adaptive radiotherapy aims to shrink treatment margins for uterine cancers
- New study challenges safety of keyhole surgery for cervical cancer
- New radiation technique could replace brachytherapy for cervical cancer