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Natural materials may speed gum graft recovery

NCT ID NCT07072546

Symptom relief Sponsor: Biruni University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested whether applying chitosan (a natural substance from shellfish) and i-PRF (a concentrate from the patient's own blood) to the wound site can improve healing after a gum graft. Sixty-eight people received one of three treatments: a standard gelatin sponge, chitosan alone, or chitosan with i-PRF. Researchers measured pain, bleeding, and how quickly the wound healed over two months. The goal is to find a way to make recovery more comfortable and faster.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
chitosan and injectable platelet-rich fibrin (i-PRF)
What this could lead to
If it works, this could lead to a simple, natural way to speed up healing and reduce pain after gum graft surgery.
What could go wrong
This is a small, completed study with 68 people. The results may not apply to everyone, and the benefits over standard care might be small.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

68 people

The number who actually took part.

Started

Jul 2025

Finished

Dec 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 65 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Periodontally healthy * Having good oral hygiene (plaque accumulation \<20%) * Requiring a free gingival graft (FGG) procedure in an area with insufficient keratinized gingiva width (\<2 mm) Exclusion Criteria: * Having systemic diseases contraindicating surgical procedures, * Uncontrolled diabetes (HbA1c \> 7), * Being pregnant or breastfeeding, * Autoimmune and/or inflammatory diseases of the oral cavity, * Active periodontal disease, * Smokers (≥ 10 cigarettes per day)

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Conditions

The condition(s) this trial relates to.

injury

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Chitosan Free gingival graft I-PRF Wound healing

Contacts and locations

Locations

  • Biruni University

    Istanbul, Turkey (Türkiye)

  • Cukurova University

    Adana, Turkey (Türkiye)

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