Vaccine boosts Chemo-Radiation against cervical cancer in early trial
NCT ID NCT04580771
First seen Nov 01, 2025 · Last updated Jun 23, 2026 · Updated 33 times
Summary
This phase 2 trial tests whether adding a vaccine called PDS0101 to standard chemoradiation is safe and effective for people with advanced cervical cancer. The vaccine trains the immune system to attack HPV-infected tumor cells. About 22 participants will receive the combination, and researchers will monitor side effects and tumor response.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Locations
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M D Anderson Cancer Center
Houston, Texas, 77030, United States
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
PDS0101 (a vaccine that helps the immune system attack HPV-infected cervical cancer cells) combined with cisplatin chemotherapy and radiation therapy
What this could lead to
If successful, this combination could offer a more effective treatment for advanced cervical cancer, potentially improving tumor shrinkage and long-term control.
What could go wrong
This is a small, early-phase trial (22 participants) focused on safety, not yet proven to work. Side effects from the vaccine, chemo, and radiation could be significant.
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.