Brain oxygen monitored in sick kids during resuscitation
NCT ID NCT03731104
First seen Jun 26, 2026 · Last updated Jun 26, 2026
Summary
This study looked at how brain blood flow and oxygen levels change when doctors treat critically ill children for shock or very low blood pressure. Researchers used a special light-based device (NIRS) and ultrasound to monitor 27 children in the intensive care unit. The goal was to understand how the brain responds during emergency treatment, which could help improve care for these young patients.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- What this could lead to
- If successful, this could help doctors better monitor brain health during emergency treatment for shock or low blood pressure in children.
- What could go wrong
- This is a small, completed observational study with only 27 participants, so findings may not apply broadly. It does not test a new treatment.
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Study facts
What this study's own registry entry says, in plain language.
- Participants
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27 people
The number who actually took part.
- Started
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Dec 2018
- Finished
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Jul 2021
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
Who is studied
Pediatric patients hospitalized in 4 french Pediatric Intensive Care Units
- Ages
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0 to 18 years
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: Neonates and children from 0 to 18 years old hospitalized in pediatric intensive care unit (PICU) with hemodynamic failure requiring vasoactive or inotropic treatment. This includes : * shock (tachycardia, troubles of peripheral perfusion with capillary refill time \>3 sec, oliguria, with or without alteration of consciousness or arterial hypotension) * isolated arterial hypotension if it needs medical treatment to readjust balance between oxygen demand and oxygen consumption Exclusion Criteria: * primitive cerebral lesion: traumatic or neurosurgical (including brain death states) * preterm neonates of less than 37 weeks gestational age * patients already receiving more than one catecholamine * patients too instable, defined by a respiratory instability (pulse oxymetry of less than 80% during more than 5 minutes) and/or hemodynamic instability (variability of blood pressure and heart rate of more than 50%) and/or cardiorespiratory arrest.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Hôpital Necker
Paris, 75015, France
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Hôpital Robert Debré
Paris, 75019, France
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Hôpital Trousseau
Paris, 75012, France
More trials for these conditions
Other studies related to the condition(s) this trial covers.
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- Non-invasive heart monitor tested against standard method in shock patients