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New pressure test may help doctors give right fluids in shock

NCT ID NCT07670390

Knowledge-focused Sponsor: Jingyuan,Xu Source: ClinicalTrials.gov ↗

What the study statuses mean

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looks at whether tissue perfusion pressure (TPP) can predict how shock patients will respond to fluids. Researchers will give a standard fluid challenge to 34 ICU patients and measure changes in TPP and cardiac output. The goal is to see if TPP is a useful tool for guiding fluid therapy in critically ill people.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If successful, this could provide doctors with a simple way to decide how much fluid to give shock patients, potentially improving care.
What could go wrong
This is a small, early observational study with only 34 people. It may not prove TPP is reliable, and results might not apply to all shock patients.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 34 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Jul 2026

An estimate. Start dates often move.

Expected to finish

Jun 2028

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

The study population will consist of critically ill adult patients with shock and tissue hypoperfusion admitted to the Intensive Care Unit of Zhongda Hospital, Southeast University. Patients requiring fluid resuscitation and invasive hemodynamic monitoring as part of routine clinical care will be screened for eligibility and consecutively enrolled in this prospective observational study.

Ages

Children (under 18), adults (18 to 64) and older adults (65 and over)

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Age ≥18 years * Admitted to the Intensive Care Unit (ICU) * Diagnosed with shock and evidence of tissue hypoperfusion * Judged by the treating physician to require fluid resuscitation * Receiving invasive hemodynamic monitoring * Written informed consent obtained from the patient or legally authorized representative Exclusion Criteria: * Pregnancy * Immediate requirement for extracorporeal life support, including: VV-ECMO, VA-ECMO, Ventricular assist devices * Expected survival less than 72 hours * Absence of invasive arterial pressure monitoring or arterial waveform availability \<25% * Any condition deemed unsuitable for study participation by the investigator.

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Conditions

The condition(s) this trial relates to.

Shock

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Shock

How to take part

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  1. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  2. A doctor treating you

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