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New cell therapy trial offers hope for Hard-to-Treat myeloma

NCT ID NCT04155749

Disease control Sponsor: Kite, A Gilead Company Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing This study
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This early-phase study tests experimental cell therapies in 40 adults with relapsed and refractory multiple myeloma who have tried at least three prior treatments. The main goal is to check safety and find the right dose. While not a cure, it aims to control the disease and may lead to better options.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 1

The first testing in people. Mainly checks safety and dose, usually in a small group.

Participants

40 people

The number who actually took part.

Started

Dec 2019

Expected to finish

May 2027

An estimate. End dates often move.

Lead sponsor

A company

The lead sponsor is a pharmaceutical, biotech, or medical-device company.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Relapsed and refractory Multiple Myeloma treated with at least 3 prior regimens of system therapy including Proteosome Inhibitor (PI), immunomodulatory drugs (IMiD), and anti-CD38 antibody (CD38mab); or has "triple-refractory" disease * Documented measurable disease * Adequate organ function * Life expectancy \> 12 weeks, Eastern Cooperative Group Performance Status 0-1 Exclusion Criteria: * Plasma Cell Leukemia or History of Plasma Cell Leukemia * Patients with a history of severe hypersensitivity to DMSO should be excluded * Contraindication to fludarabine or cyclophosphamide * Severe uncontrolled intercurrent illness (e.g., infection) or laboratory abnormalities * Active central nervous system disease involvement by malignancy or active CNS pathology

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Conditions

The condition(s) this trial relates to.

plasma cell myeloma plasma cell neoplasm Recurrence

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Relapsed and refractory multiple myeloma

Contacts and locations

Locations

  • Advanced Cellular Therapeutics Facility, DCAM 0800A

    Chicago, Illinois, 60637, United States

  • Beth Israel Deaconess Medical Center

    Boston, Massachusetts, 02215, United States

  • Froedtert Hospital/Medical College of Wisconsin

    Milwaukee, Wisconsin, 53226, United States

  • Massachusetts General Hospital

    Boston, Massachusetts, 02114, United States

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